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Histone Demethylase

Histone demethylase proteins have a variety of domains that serve different functions. These functions include binding to the histone (or sometimes the DNA on the nucleosome), recognizing the correct methylated amino acid substrate and catalyzing the reaction, and binding cofactors. Cofactors include: alpha-keto glutarate (JmjC-domain containing demethylases), CoREST (LSD), FAD, Fe (II) or NOG (N-oxalylglycine).
Cat. No. 製品名 CAS No. Purity Chemical Structure
T21652 RN-1 dihydrochloride 1781835-13-9 98%
RN-1 dihydrochloride is an effective and selective irreversible inhibitor of lysine-specific demethylase 1 (LSD1, IC50 = 70 nM).
T7057 Methylstat 1310877-95-2 98%
Methylstat is a methyl ester prodrug of a Jumonji C domain-containing histone demethylase (JMJD) inhibitor that has favorable cell permeability. The free acid of...
T77635 LSD1-IN-27 2904571-94-2 98%
LSD1-IN-27 is a potent LSD1 inhibitor with an IC50 value of 13 nM.LSD1-IN-27 inhibited the stemness and migration of gastric cancer cells.LSD1-IN-27 inhibited th...
T7942 Tranylcypromine hemisulfate 13492-01-8 98%
Tranylcypromine hemisulfate (Tranylcypromine Sulfate) is an inhibitor of monoamine oxidase (MAO) and lysine-specific demethylase 1 (LSD1) with a rapid onset of ...
T15648 KDM5-C70 1596348-32-1 98%
KDM5-C70 is an ethyl ester derivative of KDM5-C49. KDM5-C70 is an effective, cell-permeable, and pan-KDM5 histone demethylase inhibitor. KDM5-C70 has an antiprol...
T0029 Procaine 59-46-1 98%
Procaine (Vitamin H3) is a local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia...
T38318L Acetyl Pentapeptide-1 acetate 98%
Acetyl Pentapeptide-1 acetate is an histone deacetylase inhibitor.
T15649 KDM5-IN-1 1628210-26-3 98%
KDM5-IN-1 is an effective and selective inhibitor of KDM5 with an IC50 of 15.1 nM.
T6073 OG-L002 1357302-64-7 98%
OG-L002 is an effective and selective LSD1 inhibitor (IC50: 20 nM), showing 69- and 36-fold selectivity over MAO-A and MAO-B, respectively.
T39989L JQKD82 trihydrochloride T39989L 98%
JQKD82 trihydrochloride is a cell-permeable and selective KDM5 inhibitor. JQKD82 trihydrochloride increases H3K4me3 and can be used for the research of multiple ...
TN3120 5-Hydroxy-7-acetoxy-8-methoxyflavone 95480-80-1 98%
5-Hydroxy-7-acetoxy-8-methoxyflavone is a flavonoid compound that inhibits lipid peroxidation and may have anti-influenza virus activity.
T13748 L-2-Hydroxyglutaric acid disodium 63512-50-5
L-2-Hydroxyglutaric acid disodium ((S)-2-Hydroxyglutaric acid disodium) is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutari...
T22821 GSK J5 1394854-51-3 100%
GSK J5 is an inhibitor of schistosomes and helminths and is often used as a trematode insecticide.GSK J5 promotes schistosome mortality in a dose- and time-depen...
T4214 KDM4D-IN-1 2098902-68-0 100%
KDM4D-IN-1 is a KDM4D inhibitor (IC50: 0.41±0.03 μM).
T5484 GSK467 1628332-52-4 100%
GSK467 is a potent and selective inhibitor of KDM5 (JARID1)(Ki : 10 nM).
T5368 Eicosapentaenoic Acid 10417-94-4 96.20%
Eicosapentaenoic Acid (EPA) is a ω-3 fatty acid abundantly available in marine organisms.
T3100 GSK-J4 1373423-53-0 97.07%
GSK-J4 (GSK J4 HCl) is a potent H3K27me3 demethylase inhibitor, with IC50s of 8.6 μM and 6.6 μM towards KDM6B and KDM6A respectively. It is the first selective i...
T1025 Tranylcypromine (2-PCPA) hydrochloride 1986-47-6 97.19%
Tranylcypromine (2-PCPA) hydrochloride (SKF-385 HCl), a Monoamine Oxidase inhibitor, is effective in the treatment of major depression, dysthymic disorder, and a...
T6593 ML324 1222800-79-4 97.49%
ML324(IC50=920 nM) is a specific inhibitor of jumonji histone demethylase (JMJD2).
T39389 KDM2B-IN-2 1965248-01-4 97.57%
KDM2B-IN-2 is a potent histone demethylase (kdm2b) inhibitor.
RN-1 dihydrochloride
T21652
RN-1 dihydrochloride is an effective and selective irreversible inhibitor of lysine-specific demethylase 1 (LSD1, IC50 = 70 nM).
Methylstat
T7057
Methylstat is a methyl ester prodrug of a Jumonji C domain-containing histone demethylase (JMJD) inhibitor that has favorable cell permeability. The free acid of...
LSD1-IN-27
T77635
LSD1-IN-27 is a potent LSD1 inhibitor with an IC50 value of 13 nM.LSD1-IN-27 inhibited the stemness and migration of gastric cancer cells.LSD1-IN-27 inhibited th...
Tranylcypromine hemisulfate
T7942
Tranylcypromine hemisulfate (Tranylcypromine Sulfate) is an inhibitor of monoamine oxidase (MAO) and lysine-specific demethylase 1 (LSD1) with a rapid onset of ...
KDM5-C70
T15648
KDM5-C70 is an ethyl ester derivative of KDM5-C49. KDM5-C70 is an effective, cell-permeable, and pan-KDM5 histone demethylase inhibitor. KDM5-C70 has an antiprol...
Procaine
T0029
Procaine (Vitamin H3) is a local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia...
Acetyl Pentapeptide-1 acetate
T38318L
Acetyl Pentapeptide-1 acetate is an histone deacetylase inhibitor.
KDM5-IN-1
T15649
KDM5-IN-1 is an effective and selective inhibitor of KDM5 with an IC50 of 15.1 nM.
OG-L002
T6073
OG-L002 is an effective and selective LSD1 inhibitor (IC50: 20 nM), showing 69- and 36-fold selectivity over MAO-A and MAO-B, respectively.
JQKD82 trihydrochloride
T39989L
JQKD82 trihydrochloride is a cell-permeable and selective KDM5 inhibitor. JQKD82 trihydrochloride increases H3K4me3 and can be used for the research of multiple ...
5-Hydroxy-7-acetoxy-8-methoxyflavone
TN3120
5-Hydroxy-7-acetoxy-8-methoxyflavone is a flavonoid compound that inhibits lipid peroxidation and may have anti-influenza virus activity.
L-2-Hydroxyglutaric acid disodium
T13748
L-2-Hydroxyglutaric acid disodium ((S)-2-Hydroxyglutaric acid disodium) is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutari...
GSK J5
T22821
GSK J5 is an inhibitor of schistosomes and helminths and is often used as a trematode insecticide.GSK J5 promotes schistosome mortality in a dose- and time-depen...
KDM4D-IN-1
T4214
KDM4D-IN-1 is a KDM4D inhibitor (IC50: 0.41±0.03 μM).
GSK467
T5484
GSK467 is a potent and selective inhibitor of KDM5 (JARID1)(Ki : 10 nM).
Eicosapentaenoic Acid
T5368
Eicosapentaenoic Acid (EPA) is a ω-3 fatty acid abundantly available in marine organisms.
GSK-J4
T3100
GSK-J4 (GSK J4 HCl) is a potent H3K27me3 demethylase inhibitor, with IC50s of 8.6 μM and 6.6 μM towards KDM6B and KDM6A respectively. It is the first selective i...
Tranylcypromine (2-PCPA) hydrochloride
T1025
Tranylcypromine (2-PCPA) hydrochloride (SKF-385 HCl), a Monoamine Oxidase inhibitor, is effective in the treatment of major depression, dysthymic disorder, and a...
ML324
T6593
ML324(IC50=920 nM) is a specific inhibitor of jumonji histone demethylase (JMJD2).
KDM2B-IN-2
T39389
KDM2B-IN-2 is a potent histone demethylase (kdm2b) inhibitor.
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