Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ML324(IC50=920 nM) is a specific inhibitor of jumonji histone demethylase (JMJD2).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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5 mg | 在庫あり | ¥ 11,000 | |||
10 mg | 在庫あり | ¥ 16,500 | |||
25 mg | 在庫あり | ¥ 30,000 | |||
50 mg | 在庫あり | ¥ 53,500 | |||
100 mg | 在庫あり | ¥ 96,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 17,500 |
説明 | ML324(IC50=920 nM) is a specific inhibitor of jumonji histone demethylase (JMJD2). |
ターゲット&IC50 | JMJD2:920 nM |
In vitro | ML324 exhibits good Caco-2 cell permeability, and possesses excellent microsomal stability in the presence of both mouse and rat liver microsomes. ML324 demonstrates potent anti-viral activity against both herpes simplex virus (HSV) and human cytomegalovirus (hCMV) infection by inhibiting viral IE gene expression. [1] |
In vivo | In a mouse ganglia explant model of latently infected mice, ML324 suppresses the formation of HSV plaques, and blocks HSV-1 reactivation. [1] |
キナーゼ試験 | The fluorescence resonance energy transfer (FRET)-based LANCE Ultra KinaSelect Ser/Thr kit is used to determine IC50 values for various CDK inhibitors. Briefly, a specific ULight MBP peptide substrate (50 nM final concentration) is phosphorylated by a CDK-cyclin pair in buffer (50 mM HEPES-KOH pH 7.5, 10 mM MgCl2, 1 mM EGTA, 2 mM dithiothreitol) containing ATP at the concentration of the Km values of the individual kinases for 1 h at room temperature. Subsequently, phosphorylation is detected by addition of specific Eu-labelled anti-phospho-antibodies (2 nM), which upon binding to the phosphopeptide give rise to a FRET signal. FRET signals are then recorded[1]. |
分子量 | 349.43 |
分子式 | C21H23N3O2 |
CAS No. | 1222800-79-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 3 mg/mL (8.58 mM), Heating is recommended.
DMSO: 40 mg/mL (114.5 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
ML324 1222800-79-4 Chromatin/Epigenetic Microbiology/Virology Others HSV Histone Demethylase Jumonji periodontal Cytomegalovirus inhibit simplex CMV Inhibitor Herpes simplex virus human disease H3K9 herpes ML 324 virus domain immunity periodontitis inflammation ML-324 containing proteins inhibitor