Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NF-κΒ Activator 2 is a potent, orally active compound that efficiently activates NF-κB with an EC50 value of 1.58 μM. By enhancing NF-κB expression and activation, it induces SOD 2 synthesis, rendering it useful for amyotrophic lateral sclerosis (ALS) research [1].
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 36,500 | |||
5 mg | 在庫あり | ¥ 91,500 | |||
10 mg | 在庫あり | ¥ 135,500 | |||
25 mg | 在庫あり | ¥ 217,000 | |||
50 mg | 在庫あり | ¥ 294,000 | |||
100 mg | 在庫あり | ¥ 397,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 100,500 |
説明 | NF-κΒ Activator 2 is a potent, orally active compound that efficiently activates NF-κB with an EC50 value of 1.58 μM. By enhancing NF-κB expression and activation, it induces SOD 2 synthesis, rendering it useful for amyotrophic lateral sclerosis (ALS) research [1]. |
ターゲット&IC50 | NF-κB:1.58 μM (EC50) |
In vitro | NF-κB activator 2 (Compound 61) (1 μM, 6 hr) induces SOD 2 mRNA expression in SH-SY5Y neuroblastoma cells [1]. SOD2 is a highly inducible SOD that performs in concurrence with SOD1 to detoxify ROS. Induction of SOD2 can be obtained through the activation of NF-ҡBs. |
In vivo | NF-κΒ activator 2, when administered intravenously (i.v.) at a dose of 1 mg/kg, demonstrates an appropriate half-life of 0.96 hours in mice [1]. Similarly, at an oral (p.o.) dosage of 5 mg/kg, it shows a comparable half-life of 2.86 hours, an oral bioavailability of 15.6%, and a maximum concentration (C max) of 92 ng/mL [1]. |
分子量 | 298.27 |
分子式 | C16H11FN2O3 |
CAS No. | 2375281-44-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 250 mg/mL (838.17 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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NF-κΒ activator 2 2375281-44-8 NF-Κb NF-κB Nuclear factor-kappaB ALS amyotrophic Nuclear factor-κB lateral NF κΒ activator 2 NFκΒ activator 2 NF-?B Inhibitor SOD2 sclerosis NF-kb activator 2 inhibit NF-kappabeta activator 2 inhibitor