P-gp

P-glycoprotein (P-gp) is a plasma membrane protein which acts as a localized drug transport mechanism, actively exporting drugs out of the cell. The effects of P-gp on the distribution, metabolism and excretion of drugs — including protease inhibitors — in the body is great.

Cat. No.	製品名	CAS No.	Purity
T9601	Tepotinib hydrochloride(1 : x)	1103508-80-0	98%
T9601	Tepotinib hydrochloride(1 : x) is an orally bioavailable, mesenchymal-epithelial transition (MET) TKI developed mainly for selected NSCLC patients with METex14 s...
T0351	Risperidone	106266-06-2	98%
T0351	Risperidone is a selective blocker of dopamine D2 receptors and serotonin 5-HT2 receptors that act as an atypical antipsychotic agent.
T2S1120	Ganoderenic acid B	100665-41-6	98%
T2S1120	Ganoderenic acid B, a natural product derived from Ganoderma lucidum, can work by inhibiting the transport function of ABCB1 and enhancing the cytotoxicity of ch...
T12540	Pristinamycin IA	3131-03-1	98%
T12540	Pristinamycin IA is a substrate for the P-glycoprotein and a cyclo-peptidic macrolactone antibiotic.
T0100	Atazanavir sulfate	229975-97-7	98%
T0100	Atazanavir sulfate is an azapeptide and HIV-PROTEASE INHIBITOR that is used in the treatment of HIV INFECTIONS and AIDS in combination with other ANTI-HIV AGENTS...
T2S0410	Euphorbia factor L1	76376-43-7	98%
T2S0410	1. Euphorbia factor L1 can enhance the ATP hydrolysis activity of ABCB1 stimulated by verapamil. 2. Euphorbia factor L1 inhibits the efflux of ABCB1 in KBv200 an...
T12341	P-gp inhibitor 1	2050747-49-2	98%
T12341	P-gp inhibitor 1 inhibits reversing P-glycoprotein-mediated multidrug resistance with an EC50 of 57.9 nM (K562/A02 cells).
TN1425	Bacoside A3	157408-08-7	98%
TN1425	Bacoside A3 has antioxidant potential, it shows comparatively higher neuroprotective response analysed as higher cell viability and decreased intracellular ROS.
TN1651	Furanodiene	19912-61-9	98%
TN1651	Furanodiene has anti-inflammatory and antioxidant activities, it is active against gram-positive bacteria and Candida albicans.
T2S0223	Isosinensetin	17290-70-9	98%
T2S0223	1. Isosinensetin shows antioxidant and HIV-1 protease inhibiting activities.
T60009	YS-370	2470908-79-1	98%
T60009	YS-370 is an orally active inhibitor of P-gp and shows moderate inhibition against CYP3A4. YS-370 effectively reverses multidrug resistance to paclitaxel and col...
T3S0012	Coniferyl ferulate	63644-62-2	98%
T3S0012	Coniferyl ferulate is a strong inhibitor of glutathione S-transferase (GST) isolated from Radix Angelicae sinensis. It shows strong inhibition of human placental...
T2893	Muscone	541-91-3	98%
T2893	Muscone is an organic compound that is the primary contributor to the odor of musk.
T4034	Solamargine	20311-51-7	98%
T4034	Solamargine is a major steroidal alkaloid glycoside extracted from a traditional Chinese medicine herb, Solanum nigrum L. (SNL); has been shown to inhibit growth...
T2S1200	Sinapine	18696-26-9	98%
T2S1200	1. Sinapine, an alkaloid from seeds of the cruciferous species, can be used as an effective natural compound for chemo-resistance. 2. Sinapine has antioxidant an...
T1222	Trifluoperazine dihydrochloride	440-17-5	98%
T1222	Trifluoperazine Dihydrochloride is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an antiemetic.
T6287	Tariquidar	206873-63-4	98%
T6287	Tariquidar(Kd=5.1 nM) is a specific and effective non-competitive inhibitor of P-glycoprotein. It can reverse drug resistance in MDR cell Lines.
T0012	Cinchonine	118-10-5	98%
T0012	Cinchonine, a local anesthetic of the amide type, now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local narc...
TN4761	Phellamurin	52589-11-4	98%
TN4761	Phellamurin inhibits intestinal P-glycoprotein in a dose-dependent manner, there is a serious interaction occurred between Phellamurin with cyclosporin, to ensur...
T30260	AZD-5672	780750-65-4	98%
T30260	AZD-5672 is an antagonist of CCR5 with an IC50 of 0.32 nM. AZD-5672 inhibits hERG cardiac ion channel binding and P-gp-mediated digoxin transport with IC50s of 7...