Phosphatase

A phosphatase is an enzyme that uses water to cleave a phosphoric acid monoester into a phosphate ion and an alcohol. Because a phosphatase enzyme catalyzes the hydrolysis of its substrate, it is a subcategory of hydrolases. Phosphatase enzymes are essential to many biological functions, because phosphorylation (e.g. by protein kinases) and dephosphorylation (by phosphatases) serve diverse roles in cellular regulation and signaling. Whereas phosphatases remove phosphate groups from molecules, kinases catalyze the transfer of phosphate groups to molecules from ATP. Together, kinases and phosphatases direct a form of post-translational modification that is essential to the cell's regulatory network. Phosphatase enzymes are not to be confused with phosphorylase enzymes, which catalyze the transfer of a phosphate group from hydrogen phosphate to an acceptor. Due to their prevalence in cellular regulation, phosphatases are an area of interest for pharmaceutical research

Cat. No.	製品名	CAS No.	Purity
T41298	LMPTP INHIBITOR 1 dihydrochloride	2310135-46-5	98%
T41298	LMPTP INHIBITOR 1 dihydrochloride is a selective inhibitor of low molecular weight protein tyrosine phosphatase (LMPTP), with an IC50 of 0.8 μM LMPTP-A.
T61214	EWP 815	20231-01-0	98%
T61214	EWP 815 is a disulfiram analogue that functions as a powerful inhibitor of Ins(1,4) P 2 phosphatase, Ins(1,4,5) P 3 5-phosphatase, and dopamine β-hydroxylase act...
T28506	Rbin-2	2032282-97-4	98%
T28506	Rbin-2 is a cell-permeable, potent, selective and reversible inhibitor of Midasin (Mdn1).Rbin-2 directly targets the AAA+ ATPase Midasin and inhibits eukaryotic ...
T4340	SPI-112	1051387-90-6	98%
T4340	SPI-112, the SPI-112 methyl ester analog, can inhibit cellular Shp2 PTP activity. SPI-112 bound to Shp2 by surface plasmon resonance (SPR) and displayed competit...
T17235	Voclosporin	515814-01-4	98%
T17235	Voclosporin is a novel and orally available calcium-modulated phosphatase (CN; PP2B) inhibitor and immunosuppressant for the treatment of lupus nephritis.
T77661	H-NTPDase-IN-4	2939933-09-0	98%
T77661	h-NTPDase-IN-4 is a pan-inhibitor of NTPDase, which can inhibit h-NTPDase1, 1h-NTPDase2, h-NTPDase3, h-NTPDase8. The IC50 values were 3.58 μM, 10.21 μM, 0.13 μM ...
TP2054L	Calcineurin Autoinhibitory Peptide acetate		98%
TP2054L	Calcineurin Autoinhibitory Peptide acetate is a selectivecalcineurin phosphatase inhibitor(IC50 ~ 10 μM). Calcineurin Autoinhibitory Peptide acetate can be used ...
T4308	F1063-0967	613225-56-2	98%
T4308	F1063-0967 is a Dual-specificity phosphatase 26 (DUSP26) inhibitor with an IC50 of 11.62 μM.
T11929	M2N12	2376577-06-7	98%
T11929	M2N12 also has promising activity against Cdc25A and Cdc25B with IC50 values of  0.53  μM and 1.39 μM. Anti-tumor activity. M2N12 is a potent and highly selectiv...
T6353	(-)-p-Bromotetramisole Oxalate	62284-79-1	98%
T6353	p-Bromotetramisole Oxalate is a potent and non-specific inhibitor of alkaline phosphatase.
T12578	(E,E)-RAMB4	919091-61-5	98%
T12578	PTP1B-IN-8 is a potent and selective inhibitor of protein tyrosine phosphatase-1B (PTP1B).
T61678	MY10	2204270-73-3	98%
T61678	MY10 attenuates binge-like ethanol consumption and ethanol reward.MY10 is a potent and orally active receptor protein tyrosine phosphatase (RPTPβ/ζ) inhibitor.
TN1470	Cassiaside B2	218155-40-9	98%
TN1470	Cassiaside B2 is an inhibitor of protein tyrosine phosphatase 1B (PTP1B) and human monoamine oxidase A (hMAO-A).Cassiaside B2 is an agonist of the 5-HT2C recepto...
T65086	Cis-5-Norbornene-exo-2,3-dicarboxylic Anhydride	2746-19-2	98%
T65086	Cis-5-Norbornene-exo-2,3-dicarboxylic Anhydride may cause sensitization. Cis-5-Norbornene-exo-2,3-dicarboxylic Anhydride promotes apoptosis in HepG2 (IC50= 62 μM...
T3S1612	Kuwanon G	75629-19-5	98%
T3S1612	1. Kuwanon G as dual inhibitors of PTP1B and α-glucosidase enzymes, as well as insulin sensitizers, it may potentially be utilized as an effective treatment for ...
T4915	β-Glycerophosphate disodium salt hydrate	154804-51-0	98%
T4915	β-Glycerophosphate is a classical serine-threonine phosphatase inhibitor used in kinase reaction buffers. BGP is often used in combination with other phosphatase...
T39658	RMC-4630	2172652-48-9	98%
T39658	RMC-4630 is an inhibitor of SHP2.
T12519	Sodium metatungstate	12141-67-2	98%
T12519	Sodium metatungstate is a potent inhibitor of ecto-nucleoside triphosphate diphosphohydrolase (NTPDase)(Ki values of 2.58 μM, 3.26 μM, and 28.8 μM for NTPDase 1,...
T1210	Sodium etidronate	7414-83-7	98%
T1210	Etidronate Disodium is a synthetic therapeutic diphosphonate analog of endogenous pyrophosphate. As a member of the family of drugs known as bisphosphonates, eti...
TQ0032	Rosiptor	782487-28-9	98%
TQ0032	Rosiptor (AQX-1125) is an orally-active and specific phosphatase SHIP1 activator with anti-inflammatory effects.