ペプチド
抗体
色素試薬
PROTAC
バーチャルスクリーニング
TargetMolキット
Cell Counting Kit-8 (CCK-8)
Inhibitor Cocktails
天然化合物
フェノール類
アルカロイド類
フラボノイド類
阻害剤
血管新生
アポトーシス
オートファジー
細胞周期・チェックポイント
クロマチン・エピジェネティック
細胞骨格シグナル
DNA損傷・DNA修復
内分泌・ホルモン
GPCR/Gタンパク質
免疫・炎症
JAK・STATシグナル
| Cat. No. | 製品名 | CAS No. | Purity | Chemical Structure |
|---|---|---|---|---|
| T6085 | PF-543 | 1415562-82-1 | 98% |
|
| PF-543, a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM. | ||||
| T9992 | WAY-272077 | 1415662-57-5 | 98% |
|
| WAY-272077 is a sphingosine kinase inhibitor with anti-inflammatory, antitumor and hemostatic effects. | ||||
| T6403 | Siponimod | 1230487-00-9 | 98% |
|
| BAF312 (Siponimod), a next-generation S1P receptor modulator, is specific for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, respectively. The specifi... | ||||
| T3258 | Ponesimod | 854107-55-4 | 98% |
|
| Ponesimod is an orally available sphingosine-1-phosphate receptor 1 (S1PR1, S1P1) agonist that acts as a functional antagonist, with potential immunomodulating a... | ||||
| T21500 | Sphingosine-1-phosphate | 26993-30-6 | 98% |
|
| Sphingosine-1-phosphate is an agonist for S1P1-5 receptors and a ligand for GPR3, GPR6, GPR12.Sphingosine-1-phosphate is an intracellular second messenger that m... | ||||
| T38294 | 4-Deoxypyridoxine hydrochloride | 148-51-6 | 98% |
|
| 4-Deoxypyridoxine (4-DPD) is a vitamin B6 antimetabolite with diverse biological activities. It inhibits transport of pyridoxine , pyridoxal, and pyridoxamine in... | ||||
| T2026 | CYM5442 | 1094042-01-9 | 98% |
|
| CYM5442 is an S1P agonist, targeting to Sphingosine. | ||||
| T3961 | CYM-5541 | 945128-26-7 | 98% |
|
| CYM-5541 is a selective and allosteric S1P3 receptor agonist. | ||||
| T10761 | Ceranib-2 | 1402830-75-4 | 98% |
|
| Ceranib-2 is an inhibitor of ceramidase with an IC50 of 28 μM in SKOV3 cells. Ceranib-2 decreases levels of sphingosine and S1P, induces cell apoptosis and exhib... | ||||
| T7360 | GSK2018682 | 1034688-30-6 | 98% |
|
| GSK2018682 is an agonist of sphingosine-1-phosphate receptor (s1p1) and (s1p5) agonist(pEC50s of 7.7 and 7.2,respectively). | ||||
| T16128 | MP-A08 | 219832-49-2 | 98% |
|
| MP-A08 is a highly selective ATP competitive inhibitor of sphingosine kinase (SPHK1) that targets both SphK1 and SphK2 (Ki: 6.9 ± 0.8 μM and 27 ± 3 μM, respectiv... | ||||
| T9199 | GLPG2938 | 2130996-00-6 | 98% |
|
| GLPG2938 is a potent and selective antagonist of S1P2. | ||||
| T22697 | CS 2100 | 913827-99-3 | 98% |
|
| S1P1 agonist | ||||
| T22101 | ML-031 | 852230-33-2 | 98% |
|
| ML-031 activated S1P2 with an EC50 value of 1 μM in an S1P reporter assay. | ||||
| T27710 | K6PC-5 | 756875-51-1 | 98% |
|
| K6PC-5 is a ceramide derivative that acts as an activator of sphingosine kinase 1 (SPHK1), inducing a swift and temporary rise in intracellular calcium levels. W... | ||||
| T12437 | PF429242 dihydrochloride | 2248666-66-0 | 98% |
|
| PF429242 dihydrochloride is a reversible and competitive inhibitor of S1P (IC50 of 175 nM). | ||||
| T22703 | CYM-5520 | 1449747-00-5 | 98% |
|
| noncompetitive allosteric agonist of S1P2 | ||||
| T6750 | Opaganib | 915385-81-8 | 98% |
|
| ABC294640 is an orally active and specific sphingosine kinase-2 (SphK2) inhibitor (IC50: 60 μM). | ||||
| T15629 | JTE-013 | 383150-41-2 | 98% |
|
| JTE-013 is an effective and specific antagonist of S1P2. JTE-013 suppresses the specific binding of radiolabeled S1P to human and rat S1P2 (IC50s: 17 nM and 22 n... | ||||
| TQ0138 | K145 hydrochloride | 1449240-68-9 | 98% |
|
| K145 is a specific inhibitor of SphK2 (IC50: 4.30 μM), while no inhibition of SphK1 at concentrations up to 10 μM. | ||||
