keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
1. Cornuside (Comuside) has immunomodulatory activity . 2. Cornuside suppresses expression levels of cytokine-induced proinflammatory and adhesion molecules in the human endothelial cells. 3. Cornuside can treat myocardial I/R and protect the liver from CCl4-induced acute hepatotoxicity, by reducing oxidative stress and suppressing inflammatory responses. 4. Cornuside has anti-inflammatory activity by downregulations of iNOS and COX-2 due to NF-κB inhibition as well as the negative regulation of ERK1/2, p38, and JNK1/2 phosphorylations in RAW 264.7 cells. 5. Cornuside has protective potential against cerebral ischemic injury, may be due to the suppression of intracellular Ca(2+) elevation and caspase-3 activity, and improvements in mitochondrial energy metabolism and antioxidant properties.
説明 | 1. Cornuside (Comuside) has immunomodulatory activity . 2. Cornuside suppresses expression levels of cytokine-induced proinflammatory and adhesion molecules in the human endothelial cells. 3. Cornuside can treat myocardial I/R and protect the liver from CCl4-induced acute hepatotoxicity, by reducing oxidative stress and suppressing inflammatory responses. 4. Cornuside has anti-inflammatory activity by downregulations of iNOS and COX-2 due to NF-κB inhibition as well as the negative regulation of ERK1/2, p38, and JNK1/2 phosphorylations in RAW 264.7 cells. 5. Cornuside has protective potential against cerebral ischemic injury, may be due to the suppression of intracellular Ca(2+) elevation and caspase-3 activity, and improvements in mitochondrial energy metabolism and antioxidant properties. |
植物由来 |
別名 | 7-Galloylsecologanol, 7-O-Galloylsecologanol, Comuside |
分子量 | 542.49 |
分子式 | C24H30O14 |
CAS No. | 131189-57-6 |
keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 65 mg/mL (119.82 mM)
Pyridine, Methanol, etc.: Soluble
Ethanol: Soluble
You can also refer to dose conversion for different animals. 詳細
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Cornuside 131189-57-6 MAPK NF-Κb p38 MAPK NF-κB ERK JNK Inhibitor 7-Galloylsecologanol 7-O-Galloylsecologanol Nuclear factor-kappaB inhibit Nuclear factor-κB Comuside inhibitor