Powder: -20°C for 3 years | In solvent: -80°C for 1 year
(R)-GNE-140 (GNE-140) is an effective LDHA/LDHB inhibitor (IC50s: 3/5 nM) and is 18-fold more potent than S enantiomer.
説明 | (R)-GNE-140 (GNE-140) is an effective LDHA/LDHB inhibitor (IC50s: 3/5 nM) and is 18-fold more potent than S enantiomer. |
ターゲット&IC50 | LDHB:5 nM, LDHA:3 nM |
In vitro | (R)-GNE-140 (5 μM) inhibits proliferation in 37 of 347 cancer cell lines. (R)-GNE-140 has an inhibitory effect on two chondrosarcomas (bone) cancer cell lines that harbor IDH1 mutations (IC50: 0.8 mΜ). |
In vivo | (R)-GNE-140 (5 mg/kg) has high bioavailability in mice. (R)-GNE-140 (50-200 mg/kg, p.o.) has greater exposure. |
別名 | GNE-140 |
分子量 | 499.04 |
分子式 | C25H23ClN2O3S2 |
CAS No. | 2003234-63-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 14.43 mg/mL (28.92 mM)
H2O: < 0.1 mg/mL (insoluble)
You can also refer to dose conversion for different animals. 詳細
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(R)-GNE-140 2003234-63-5 Metabolism Dehydrogenase Inhibitor LDH GNE-140 (R) GNE 140 GNE 140 GNE140 inhibit Lactate Dehydrogenase (R)GNE140 inhibitor