Powder: -20°C for 3 years | In solvent: -80°C for 1 year
1. β,β-Dimethylacrylshikonin (Dimethylacrylshikonin) is a promising agent for developing an improved strategy for radiotherapy against tumors. (a) Injection of Dimethylacrylshikonin combined with IR treatment significantly suppressed tumor growth of the HCT-116 xenograft. (b) Dimethylacrylshikonin significantly suppressed the growth of H(22) transplantable hepatoma, and induced the activation of caspase-3 . (c) Dimethylacrylshikonin inhibited growth of gastric cancer SGC-791 cells by inducing ERK signaling pathway. 2. Dimethylacrylshikonin inhibits the proliferation of MCF-7 cells in vitro by inducing apoptosis through the downregulation of Bcl-2, upregulation of Bax and partial inactivation of the NF-κB pathway.
説明 | 1. β,β-Dimethylacrylshikonin (Dimethylacrylshikonin) is a promising agent for developing an improved strategy for radiotherapy against tumors. (a) Injection of Dimethylacrylshikonin combined with IR treatment significantly suppressed tumor growth of the HCT-116 xenograft. (b) Dimethylacrylshikonin significantly suppressed the growth of H(22) transplantable hepatoma, and induced the activation of caspase-3 . (c) Dimethylacrylshikonin inhibited growth of gastric cancer SGC-791 cells by inducing ERK signaling pathway. 2. Dimethylacrylshikonin inhibits the proliferation of MCF-7 cells in vitro by inducing apoptosis through the downregulation of Bcl-2, upregulation of Bax and partial inactivation of the NF-κB pathway. |
植物由来 |
別名 | Dimethylacrylshikonin, β, β-Dimethylacrylshikonin |
分子量 | 370.4 |
分子式 | C21H22O6 |
CAS No. | 24502-79-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 3.7 mg/mL (10 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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β,β-Dimethylacrylshikonin 24502-79-2 Chromatin/Epigenetic MAPK Metabolism ERK HIF/HIF Prolyl-Hydroxylase Isoarnebin I Inhibitor inhibit Dimethylacrylshikonin b, b-Dimethylacrylshikonin beta,beta-Dimethylacrylshikonin β,β Dimethylacrylshikonin b,b-Dimethylacrylshikonin β,βDimethylacrylshikonin beta, beta-Dimethylacrylshikonin β, β-Dimethylacrylshikonin inhibitor