Powder: -20°C for 3 years | In solvent: -80°C for 1 year
1V209 (TLR7 agonist T7) is a Toll-like receptor 7 (TLR7) agonist and has anti-tumor effects.
説明 | 1V209 (TLR7 agonist T7) is a Toll-like receptor 7 (TLR7) agonist and has anti-tumor effects. |
In vitro | The small molecule synthetic TLR7 ligand, 2-methoxyethoxy-8-oxo-9-(4-carboxy benzyl)adenine (1V209), and α-mannose were coimmobilized via linker molecules consisting of thioctic acid on the GNP surface (1V209-αMan-GNPs).?The in vitro cytokine production activity of 1V209-αMan-GNPs was higher than that of the unconjugated 1V209 derivative in mouse bone marrow-derived dendritic cells and in human peripheral blood mononuclear cells[1]. |
In vivo | In the in vivo immunization study, 1V209-αMan-GNPs induced significantly higher titers of IgG2c antibody specific to ovalbumin as an antigen than did unconjugated 1V209, and splenomegaly and weight loss were not observed[1]. |
別名 | TLR7 agonist T7 |
分子量 | 359.34 |
分子式 | C16H17N5O5 |
CAS No. | 1062444-54-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 83.33 mg/mL (231.90 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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1V209 1062444-54-5 Immunology/Inflammation TLR cell polysaccharides 1V-209 1V 209 IP-10 intravenous TLR7 agonist T7 MCP-1 Tumor IL-6 Toll-like Receptor (TLR) conjugate Inhibitor cancer TNFα inhibit inhibitor