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Search Results for " IL-6 "

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180

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天然化合物

124

リコンビナントタンパク質

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カタログ番号	製品名	別名	ターゲット
TP1422	Interleukin (IL)-6 Receptor		Others
	Interleukin (IL)-6 Receptor is a peptide.		Others
T8477	IQ-3		JNK
	IQ3 is a selective inhibitor of JNK3(JNK3, JNK1 and JNK2 with Kd of 66 nM, 240 nM and 290 nM, respectively). IQ 3 inhibits NF-κB/AP1 transcriptional activity in THP1-Blue cells with IC50 of 1.4 μM, also inhibits TNF-α an...		JNK
T9926	Omalizumab		Others
	Omalizumab is a recombinant humanized monoclonal antibody against human immunoglobulin E IgE)		Others
T5110	IRAK inhibitor 6		IRAK
	IRAK inhibitor 6 is an inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK-4, IC50: 160 nM).		IRAK
T8692	(Rac)-Benpyrine		TNF
	(Rac)-Benpyrine is a potent and orally active inhibitor of TNF-α.		TNF
T6761	Ossirene	AS101	IL Receptor , Caspase , Interleukin
	Ossirene (AS101), a potent in vitro and in vivo immunomodulator, is a novel inhibitor of IL-1beta converting enzyme.		IL Receptor , Caspase , Interleukin
T40423	L48H37
	L48H37 is a chemically stable analog of Curcumin. It exhibits potent inhibitory properties against myeloid differentiation protein 2 (MD2), acting as a specific inhibitor. Its mechanism involves inhibiting the interactio...
T27695	JTE-607	JTE-607 dihydrochloride,JTE-607 HCl	Cysteine Protease
	JTE-607 is a cytokine production inhibitor. JTE-607 induces apoptosis accompanied by an increase in p21waf1/cip1 in acute myelogenous leukemia cells.		Cysteine Protease
T6927	Pamapimod	R1503,Ro4402257	p38 MAPK , Autophagy
	Pamapimod (R1503) (R-1503, Ro4402257) is a novel, selective inhibitor of p38 mitogen-activated protein kinase. It inhibits p38α and p38β enzymatic activity with IC50 values of 0.014±0.002 and 0.48± 0.04 microM, respectiv...		p38 MAPK , Autophagy
T8705	BOT-64		IκB/IKK
	BOT-64 is an IKK-2 inhibitor which targets the Ser177 and/or Ser181 residues in the kinase's activation loop domain.BOT-64 is a cell-permeable benzoxathiole compound		IκB/IKK
T14943	CGP60474		VEGFR , CDK , PKC
	CGP60474 is an inhibitor of VEGFR-2 (IC50 = 84 nM) and an inhibitor of ATP-competitive PKC. CGP60474 is also a highly potent anti-endotoxemic agent and inhibits cyclin-dependent kinase (CDK) potently.		VEGFR , CDK , PKC
T11793	KY-05009		Wnt/beta-catenin
	KY-05009 is a chemical compound that effectively suppresses TGF-β1-induced epithelial-to-mesenchymal transition (EMT) in human lung adenocarcinoma cells, reduces TNIK protein expression and the transcriptional activity o...		Wnt/beta-catenin
T2036	6-OAU	GTPL5846	GPR
	6-OAU (GTPL5846)(GTPL5846; 6-n-octylaminouracil) is a surrogate agonist of GPR84; activates human GPR84 in the presence of Gqi5 chimera in HEK293 cells with an EC50 of 105 nM in the PI assay.		GPR
T4602	Hydrocortisone hemisuccinate	Hydrocortisone 21-he,hydrocortisone 21-hemisuccinate*free acid,Hydrocortisone 21-hemisuccinate	Glucocorticoid Receptor , Others , Interleukin
	Hydrocortisone hemisuccinate (hydrocortisone 21-hemisuccinate*free acid) is a corticosteroid used as an analytical and chromatography reagent.		Glucocorticoid Receptor , Others , Interleukin
T6950	PNU-120596	NSC 216666	AChR
	PNU-120596 (NSC-216666) is a positive allosteric modulator of α7 nAChR with EC50 of 216 nM.		AChR
T16501	PF-3644022		p38 MAPK , Serine Protease , MAPK
	PF-3644022 is an effective, selective, and ATP-competitive MAPKAPK2 (MK2) inhibitor (IC50: 5.2 nM and a Ki of 3 nM). PF-3644022 potently inhibits TNFα production and has an anti-inflammatory effect. PF-3644022 also inhib...		p38 MAPK , Serine Protease , MAPK
TQ0181	Resatorvid	CLI-095,TAK-242	TNF , TLR , Autophagy , Interleukin
	Resatorvid (TAK-242) is a selective inhibitor of Toll-like receptor 4 (TLR4). Resatorvid binds directly to Cys747 and prevents TLR4 from binding to TIRAP, thereby blocking downstream signaling. Resatorvid has antitumor a...		TNF , TLR , Autophagy , Interleukin
T2544	Bazedoxifene acetate	WAY-TES 424,TSE 424,WAY-140424	Estrogen Receptor/ERR , Estrogen/progestogen Receptor
	Bazedoxifene acetate (WAY-TES 424) is a novel selective estrogen receptor modulator (SERM).		Estrogen Receptor/ERR , Estrogen/progestogen Receptor
T6404	Bazedoxifene hydrochloride	Bazedoxifene HCl,TSE-424	Estrogen Receptor/ERR , Estrogen/progestogen Receptor
	Bazedoxifene hydrochloride (TSE-424) is a novel, non-steroidal, indole-based estrogen receptor modulator (SERM) binding to both ERα and ERβ with IC50 of 23 nM and 89 nM, respectively.		Estrogen Receptor/ERR , Estrogen/progestogen Receptor
T15769	LMT-28		IL Receptor
	LMT-28 is an inhibitor of IL-6 and selectively inhibits IL-6-induced phosphorylation of gp130, STAT3, and JAK2.		IL Receptor
T76722	Sarilumab	REGN-88,SAR-153191	IL Receptor
	Sarilumab （SAR-153191）is a potent interleukin-6 IL-6 receptor antagonist and a human immunoglobulin G1 monoclonal antibody. Sarilumab inhibits IL-6-mediated signaling and reduces inflammation.Sarilumab is used for the pr...		IL Receptor
T4403	AX-024 hydrochloride	AX-024 HCl	IL Receptor , TNF , COX , IFNAR , Interleukin
	AX-024 hydrochloride (AX-024 HCl) is an cytokine release inhibitor which can strongly inhibit the production of interleukin-6 (IL-6), tumor necrosis factor-α (TNFα), interferon-γ (IFN-γ), IL-10 and IL-17A.		IL Receptor , TNF , COX , IFNAR , Interleukin
T9581	ARRY-797	ARRY-371797	IL Receptor , p38 MAPK
	ARRY-797 (ARRY-371797) is a potent and selective p38α inhibitor and inhibits LPS-Induced IL-6.		IL Receptor , p38 MAPK
T9911	Tocilizumab		Interleukin
	Tocilizumab (anti-IL-6R) is a humanized monoclonal antibody that binds to the interleukin-6 receptor		Interleukin
T75174	Anti-inflammatory agent 42		IL Receptor , TNF
	Anti-inflammatory agent 42 has anti-inflammatory activity and inhibits the expression of TNF-α and IL-6 in LPS-stimulated macrophages.		IL Receptor , TNF
T28958	TG6-129	TG6 129	Prostaglandin Receptor
	TG6-129 is an antagonist of the EP2 receptor. TG6-129 suppresses PGE2-induced elevation of cAMP in cells expressing EP2 with an IC50 value of 1.6 µM. TG6-129 reduces the expression of COX-2, IL-1β, IL-6, IL-12, IL-23 and...		Prostaglandin Receptor
T60739L	Y13g dihydrochloride	Y13g 2HCl(T60739 Free base)	IL Receptor , AChE
	Y13g dihydrochloride is a potent inhibitor of interleukin 6 (IL-6) and acetylcholinesterase (AChE) (both targets of Alzheimer's disease (AD) progression are related). Y13g dihydrochloride reverses STZ-induced memory defi...		IL Receptor , AChE
T67924	ABzOH
	ABzOH is a benzoic acid derivative, similar in structure to non-steroidal anti-inflammatory drugs such as aspirin, with anti-inflammatory, anti-tumor and anti-proliferative effects. ABzOH can not only inhibit the express...
T76978	Siltuximab	CNTO-328	IL Receptor
	Siltuximab（CNTO-328） is a monoclonal antibody with anti-tumor activity targeting IL-6 for the study of giant lymph node hyperplasia (MCD) and COVID-19.		IL Receptor
T7606	Guanosine 5'-diphosphate disodium salt	5'-GDP-Na2	Endogenous Metabolite
	Guanosine 5'-diphosphate disodium salt (5'-GDP-Na2) is a nucleoside diphosphate, is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulating the interleukin-6 (IL-6)/stat-3 pathway.		Endogenous Metabolite
T11079	NMI 8739	n-docosahexaenoyl dopamine,Dha-DA conjugate	Dopamine Receptor
			Dopamine Receptor
T76727	Teprotumumab	R 1507,HZN 001	TSH Receptor , IGF-1R
	Teprotumumab is a human monoclonal antibody that blocks the IGF-1 receptor (IGF-1R). Teprotumumab binds to the extracellular α-subunit domain ligand of IGF-1R. Teprotumumab inhibits TSH and IGF-1 action in fibrocytes. Te...		TSH Receptor , IGF-1R
T37113	Z62954982	ZINC08010136	Rho
	Z62954982 (ZINC08010136) is a selective inhibitor of Rac1, which stunts the growth and branching of neurons.Z62954982 inhibits Rac1 activation and reduces proliferation, p38 phosphorylation, and IL-6 levels in pulmonary ...		Rho
T64359	Anti-inflammatory agent 36		Immunology/Inflammation related
	Anti-inflammatory agent 36 is an anti-inflammatory agent. It exhibited dose-dependent inhibition of LPS-induced release of TNF-a and IL-6 in active RAW 264.7 mouse macrophages, IC50=3.69uM and 3.68uM, respectively.		Immunology/Inflammation related
T63067	Emprumapimod
	Emprumapimod is a selective, orally active inhibitor of p38α MAPK. emprumapimod acts on RPMI-8226 cells and directly inhibits LPS-induced IL-6 production with an IC50 value of 100 pM. emprumapimod can be used to study di...
T12781	RV01		Others
	RV01 is a novel quinoline-substituted analogue of resveratrol that inhibits DNA damage, reduces ethanol-induced acetaldehyde dehydrogenase (ALDH2) mRNA expression, and has hydroxyl radical scavenging activity. rV01 reduc...		Others
T76711	Golimumab	MK-8259,SCH 900259,CNTO-148	TNF
	Golimumab (CNTO-148) is a potent humanized anti-TNFα IgG1κ monoclonal antibody.Golimumab has anti-inflammatory and anticancer activity, inhibits the production of IL-6 and IL-1β, and induces apoptosis.Golimumab can be us...		TNF
T25150	BI-69A11	BI 69A11,(E)-3-(1H-Benzo[d]imidazol-2-yl)-1-(6-chloro-2-hydroxy-4-phenylquinolin-3-yl)prop-2-en-1-one	NF-κB , Akt
	BI-69A11 ((E)-3-(1H-Benzo[d]imidazol-2-yl)-1-(6-chloro-2-hydroxy-4-phenylquinolin-3-yl)prop-2-en-1-one) is a dual AKT and NFkB pathway inhibitor. It enhances the susceptibility of colon cancer cells to mda-7/IL-24-induce...		NF-κB , Akt
T13063	T6167923		MyD88
	T6167923 is a potent, selective inhibitor of MyD88-dependent signaling pathways. It achieves this by directly binding to the Toll/IL1 receptor (TIR) domain of MyD88, preventing MyD88 homodimer formation. Subsequently, T6...		MyD88
T32114	Hydrocortisone aceponate	Suniderma,Efficort,Hydrocortisone 17-propionate 21-acetate	Glucocorticoid Receptor
	Hydrocortisone aceponate (Hydrocortisone 17-propionate 21-acetate) is an effective topical glucocorticoid used in the form of a cream to treat various skin diseases.		Glucocorticoid Receptor
T3537	GSK583		RIP kinase
	GSK583 is a highly effective and specific RIP2 kinase inhibitor (IC50: 5 nM).		RIP kinase
T2548	Diflorasone		Glucocorticoid Receptor
	Diflorasone is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive properties. Like other glucocorticoids, diflorasone enters the cell by diffusion across the cell membrane and binds to the glucocorti...		Glucocorticoid Receptor
T9948	NecroX-7	LC-280126,LC28-0126,LC28 0126	NADPH-oxidase
	NecroX-7 (LC-280126) is a potent free radical scavenger and a HMGB1 (high-mobility group box 1) inhibitor. NecroX-7 can be used as an antidote to acetaminophen toxicity. NecroX-7 exerts a protective effect by preventing ...		NADPH-oxidase
T15017	CU-T12-9		TLR
	CU-T12-9 is a potent TLR1/2 agonist(EC50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay). It acts by activating the NFkB pathway, upregulating proinflammatory cytokines, and enhancing TLR1 and TLR2 dimerization.CU-T12-9 activat...		TLR
T6838	FLLL32		Apoptosis , JAK , STAT
	FLLL32 is an effective JAK2/STAT3 inhibitor (IC50 of <5 μM).		Apoptosis , JAK , STAT
T0304	Methylthiouracil	NSC-193526,NSC-9378,MTU	ERK , Antiviral , TNF , NF-κB , Interleukin
	Methylthiouracil (NSC-193526) is a thiourea antithyroid agent that inhibits the synthesis of thyroid hormone, and it is used to treat hyperthyroidism.		ERK , Antiviral , TNF , NF-κB , Interleukin
T12079	ML604440		Proteasome
	ML604440 is a cell permeable proteasome β1i (LMP2) subunit inhibitor.		Proteasome
T7672	MD2-TLR4-IN-1		TLR
	MD2-TLR4-IN-1 is a myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex inhibitor.		TLR
T38361	GSK717		IL Receptor , NOD
	GSK717 is a potent, selective NOD2 (nucleotide-binding oligomerization domain 2) inhibitor. GSK717 inhibits muramyl dipeptide (MDP)-induced NOD2-mediated signaling, with an IC50 of 400 nM for MDP-stimulated IL-8 secretio...		IL Receptor , NOD
TP1516L	C-Reactive Protein (CRP) 77-82 acetate	C-Reactive Protein (CRP) 77-82 acetate(130349-01-8 free base)	Others
	C-Reactive Protein (CRP) 77-82 acetate is the 77-82 fragment of C-Reactive Protein. C-Reactive Protein (CRP), the prototypic marker of inflammation, is a cardiovascular risk marker and may promote atherogenesis.C-reactiv...		Others

Compounds

Interleukin (IL)-6 Receptor

Target: IL Receptor, Caspase, Interleukin

Synonym: JTE-607 dihydrochloride,JTE-607 HCl

Target: Cysteine Protease

Pamapimod

T6927

Synonym: R1503,Ro4402257

Target: p38 MAPK, Autophagy

Target: VEGFR, CDK, PKC

KY-05009

T11793

Synonym:

Target: Wnt/beta-catenin

Hydrocortisone hemisuccinate

T4602

Synonym: Hydrocortisone 21-he,hydrocortisone 21-hemisuccinate*free acid,Hydrocortisone 21-hemisuccinate

Target: Glucocorticoid Receptor, Others, Interleukin

Target: p38 MAPK, Serine Protease, MAPK

Resatorvid

TQ0181

Synonym: CLI-095,TAK-242

Target: TNF, TLR, Autophagy, Interleukin

Bazedoxifene acetate

T2544

Synonym: WAY-TES 424,TSE 424,WAY-140424

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor

Bazedoxifene hydrochloride

T6404

Synonym: Bazedoxifene HCl,TSE-424

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor

Synonym: REGN-88,SAR-153191

Target: IL Receptor, TNF, COX, IFNAR, Interleukin

ARRY-797

T9581

Synonym: ARRY-371797

Target: IL Receptor, p38 MAPK

Anti-inflammatory agent 42

T75174

Synonym:

Target: IL Receptor, TNF

TG6-129

T28958

Synonym: TG6 129

Target: Prostaglandin Receptor

Y13g dihydrochloride

T60739L

Synonym: Y13g 2HCl(T60739 Free base)

Target: IL Receptor, AChE

Guanosine 5'-diphosphate disodium salt

T7606

Synonym: 5'-GDP-Na2

Target: Endogenous Metabolite

NMI 8739

T11079

Synonym: n-docosahexaenoyl dopamine,Dha-DA conjugate

Target: Dopamine Receptor

Teprotumumab

T76727

Synonym: R 1507,HZN 001

Target: TSH Receptor, IGF-1R

Z62954982

T37113

Synonym: ZINC08010136

Target: Rho

Anti-inflammatory agent 36

T64359

Synonym:

Target: Immunology/Inflammation related

Synonym: MK-8259,SCH 900259,CNTO-148

Target: TNF

BI-69A11

T25150

Synonym: BI 69A11,(E)-3-(1H-Benzo[d]imidazol-2-yl)-1-(6-chloro-2-hydroxy-4-phenylquinolin-3-yl)prop-2-en-1-one

Hydrocortisone aceponate

T32114

Synonym: Suniderma,Efficort,Hydrocortisone 17-propionate 21-acetate

Target: Glucocorticoid Receptor

Target: Glucocorticoid Receptor

NecroX-7

T9948

Synonym: LC-280126,LC28-0126,LC28 0126

Target: NADPH-oxidase

Target: Apoptosis, JAK, STAT

Methylthiouracil

T0304

Synonym: NSC-193526,NSC-9378,MTU

Target: ERK, Antiviral, TNF, NF-κB, Interleukin

Target: IL Receptor, NOD

C-Reactive Protein (CRP) 77-82 acetate

TP1516L

Synonym: C-Reactive Protein (CRP) 77-82 acetate(130349-01-8 free base)

Target: Others

カタログ番号	製品名	別名	ターゲット
TN6739	Angoline	6-Methoxyldihydrochelerythrine	IL Receptor , STAT
	Angoline (6-Methoxyldihydrochelerythrine) hydrochloride is a potent and selective IL6/STAT3 signaling pathway inhibitor(IC50 : 11.56 μM). It inhibits STAT3 phosphorylation and its target gene expression, and inhibits can...		IL Receptor , STAT
TN6722	Terminolic acid	2α,6β,23-trihydroxyl oleanolic acid	Antibacterial
	Terminolic acid (2α,6β,23-trihydroxyl oleanolic acid) is a pentacyclic triterpenoid glucoside isolated from Combretum racemosum, can inhibit the pro-inflammatory cytokines by binding to receptor active site of IL-1β and ...		Antibacterial
T2893	Muscone	3-Methylcyclopentadecanone,Methylexaltone	MMP , TNF , NF-κB , NOD-like Receptor (NLR) , P-gp , Interleukin
	Muscone (3-Methylcyclopentadecanone) is an organic compound that is the primary contributor to the odor of musk.
TN1520	Isoforskolin	Coleonol B	IL Receptor , TNF
	Isoforskolin is derived from Coleus forskohlii and reduces the secretion of TNF-α, IL-1β, IL-6 and IL-8 in human mononuclear leukocytes. Isoforskolin can be used in studies about the treatment of Lyme arthritis.		IL Receptor , TNF
T40660	Kansuinine B		IL Receptor , SARS-CoV
	Kansuinine B inhibits Stat3 activation induced by IL-6. Kansuinine B exhibits anti-viral activity and could be used in COVID-19 research.		IL Receptor , SARS-CoV
TN6393	Fulvotomentoside A		Others
	Fulvotomentoside A could decrease overexpression of IL-6 and IL-17A, and increase the expression of specific transcription factor Foxp3 of regulatory T cells significantly in intestine. It may be one of the mechanisms th...		Others
TQ0218	Deoxyandrographolide	14-deoxyandrographolide	IL Receptor , TNF
			IL Receptor , TNF
TN6778	Umbelliprenin	7-[[(2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrienyl]oxy]-2H-1-benzopyran-2-oneUmbelliprenin	IL Receptor
	Umbelliprenin (7-[[(2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrienyl]oxy]-2H-1-benzopyran-2-oneUmbelliprenin) alleviated neuropathic pain, and decreased serum IL-6 levels and oxidative stress.		IL Receptor
TN4379	Kansuinine A		IL Receptor , STAT , Interleukin
	Kansuinine A possesses analgesic props, it also shows NGF inducing activity.		IL Receptor , STAT , Interleukin
T1048	Estradiol	E2,17β-Estradiol,17β-Oestradiol,β-Estradiol	Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Endogenous Metabolite
	Estradiol (E2) is a naturally occurring steroidal sex hormone that is essential for female fertility and maintenance of secondary sexual characteristics. Estradiol upregulates IL-6 expression through estrogen receptor be...
TN1154	Nepetin	6-Methoxyluteolin	Calcium Channel , Histamine Receptor
	Nepetin (6-Methoxyluteolin) has antioxidant activity, it is a potent inhibitor of histamine release and calcium influx via down-regulation of the FcεRI α chain.		Calcium Channel , Histamine Receptor
T6S1597	Mulberroside A		TNF , Tyrosinase , Interleukin
	1. Mulberroside has nephroprotective, hypoglycemic, and antidiabetic effects. 2. Mulberroside A is a glycosylated stilbene of oxyresveratrol; thus, the deglycosylation of Mulberroside A resulted in enhanced inhibition of...		TNF , Tyrosinase , Interleukin
T6S0139	Neobavaisoflavone		Apoptosis , DNA/RNA Synthesis
	1. Neobavaisoflavone is isolated as a DNA polymerase inhibitor. 2. Neobavaisoflavone might be a potential anabolic agent to treat bone loss-associated diseases. 3. Neobavaisoflavone has anti-inflammatory activity, can si...		Apoptosis , DNA/RNA Synthesis
T3809	Liriope muscari baily saponins C		Others
	Liriope muscari baily saponins C has an anti-thrombotic activity due to down-regulation of the increased mRNA expression levels of TF and IL-6.		Others
T2791	Pectolinarin		Apoptosis , Others , NO Synthase , Prostaglandin Receptor , Interleukin
	Pectolinarin is a Cirsium isolate with anti-inflammatory activity.
T4S0145	Corylifol A	Corylinin	hCE , STAT , UGT
	1. Corylifol A (Corylinin) displays cytotoxic activity against HepG2 and Hep3B hepatocellular carcinoma cell lines, with IC50 values of 4.6 and 13.5 ug/ml, respectively. 2. Corylifol A and Biochanin A can be the potentia...		hCE , STAT , UGT
T5S1981	Alpha-Cyperone	(+)-α-Cyperone,α-Cyperone	Others , Endogenous Metabolite
	1. alpha-Cyperone (α-Cyperone) is a promising inhibitor of Hla production by S. aureus and protects lung cells from this bacterium. 2. alpha-Cyperone significantly inhibited PGE2 production by suppressing the LPS-induced...		Others , Endogenous Metabolite
T2932	Ginsenoside Rh1	Sanchinoside B2,Prosapogenin A2,20(S)-Ginsenoside Rh1,Sanchinoside Rh1	IL Receptor , TNF , Endogenous Metabolite , PPAR , Interleukin
	Ginsenoside Rh1 (Sanchinoside B2) , one of the main constituents of Panax ginseng, exhibits anti-inflammatory effect.
T2758	Madecassic acid	6-Deoxy-L-Galactose,L-Fucose,Brahmic acid,L-fucopyranose	Others , TNF , COX , NO Synthase , Interleukin
	Madecassic acid (L-fucopyranose) is extracted from the whole herb of Centella asiatica.		Others , TNF , COX , NO Synthase , Interleukin
T3662	Eleutheroside E		NF-κB
	Eleutheroside E has anti-inflammatory effects by inhibiting NF-κB activities. Eleutheroside E significantly decreases the inflammatory cell infiltration, pannus formation, cartilage damage, bone erosion of CIA mice, the ...		NF-κB
T7210	Guanosine 5'-diphosphate	GDP	Endogenous Metabolite
	Guanosine 5'-diphosphate (GDP) as Potential Iron Mobilizer, Preventing the Hepcidin-Ferroportin Interaction and Modulating the Interleukin-6/Stat-3 Pathway.		Endogenous Metabolite
T3816	Velutin		NF-κB , HIF/HIF Prolyl-Hydroxylase
	Velutin shows the strongest inhibitory effect in NF-κB activation and exhibits the greatest effects in blocking the degradation of inhibitor of NF-κB as well as in inhibiting mitogen-activated protein kinase p38 and JNK ...		NF-κB , HIF/HIF Prolyl-Hydroxylase
Fr14115	α-Terpineol	Terpineol	IL Receptor , Anti-infection , Antibacterial
	Terpineol possesses antifungal activity against Trichophyton mentagrophytes, it also exhibits strong antimicrobial activity against periodontopathic and cariogenic bacteria. α-Terpineol (Terpineol) shows anticonvulsant, ...		IL Receptor , Anti-infection , Antibacterial
T8033	Sodium Thiocyanate		Others , Reactive Oxygen Species , Interleukin
	Sodium Thiocyanate, one of the main sources of the thiocyanate anion, is used as a precursor for the synthesis of pharmaceuticals and other specialty chemicals.		Others , Reactive Oxygen Species , Interleukin
TN1410	Asperulosidic acid	ASPA	ERK , NF-κB
	Asperulosidic acid (ASPA) has anti-tumor, anti-oxidant, and anti-inflammatory activities. ASPA is related to the inhibition of inflammatory cytokines (TNF-α, IL-6) and mediators via suppression of the NF-κB and mitogen-a...		ERK , NF-κB
T8152	6-Demethoxytangeretin		MAPK , ALK
	6-Demethoxytangeretin is a citrus flavonoid isolated from Citrus depressa.		MAPK , ALK
T5S0167	Atractylenolide I		IL Receptor , TNF , TLR , JAK , STAT
	1. Atractylenolide-I has an anti-inflammatory effect by inhibiting TNF-α and IL-6 production; ameliorates sepsis syndrome, liver and kidney functions by reduction of pro-inflammatory cytokines and LPS. 2. Atractylenolide...		IL Receptor , TNF , TLR , JAK , STAT
T0798	Triamcinolone	Fluoxyprednisolone,Aristocort,Rodinolone	Glucocorticoid Receptor , COX
	Triamcinolone (Aristocort) is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. Upon cell entry, triamcinolone binds to and activates the glucocorticoid receptor, which leads to transloca...		Glucocorticoid Receptor , COX
TN5171	Tricetin		Apoptosis , Others , Nrf2
	Tricetin is a flavonoid isolated from pomegranate.Tricetin is a potent competitive inhibitor of Keap1-Nrf2 protein-protein interaction (PPI) and protects Parkinson's disease patients from 6-OHDA-induced neurotoxicity by ...		Apoptosis , Others , Nrf2
T3926	Echinatin	Retrochalcone	Free radical scavengers
	Echinatin (Retrochalcone) disturb the mitochondrial energy transfer reactions and membrane permeability, at a low concentration cause deterioration of respiratory control and oxidative phosphorylation of isolated rat liv...		Free radical scavengers
T3398	Icaritin	Anhydroicaritin,Cycloicaritin	Apoptosis , JAK , STAT , Autophagy
	Icaritin (Anhydroicaritin) has hormone regulation activity and cardiovascular function improvement activity. Icaritin has anticancer activity, can induce S phase arrest and apoptosis, inhibit ENKL cell proliferation. Ica...		Apoptosis , JAK , STAT , Autophagy
T4S2063	Tetrahydrocoptisine	STYLOPINE	ERK , p38 MAPK , NF-κB
	1. Tetrahydrocoptisine (STYLOPINE) has effective effects in suppressing inflammation. 2. Tetrahydrocoptisine possesses a protective effect on LPS-induced ALI through inhibiting of NF-κB signaling pathways, which may invo...		ERK , p38 MAPK , NF-κB
TJS0338	4-Methylesculetin	4-Methyl-6,7-dihydroxycoumarin,Methylesculetin	Antioxidant , Glutathione Peroxidase
	4-Methylesculetin (Methylesculetin) is one of the coumarin derivatives with great anti-oxidant and anti-inflammatory activities.		Antioxidant , Glutathione Peroxidase
T6S1315	Oroxylin A	6-Methoxybaicalein,Baicalein 6-methyl ether	Virus Protease , HIF/HIF Prolyl-Hydroxylase , Autophagy
	1. Oroxylin A (Baicalein 6-methyl ether) has various anti-tumor effects including apoptosis, cell cycle arrest, drug-resistant reversion. 2. Oroxylin A possesses abilities of inhibiting the ATRA-induced IL-6 production v...		Virus Protease , HIF/HIF Prolyl-Hydroxylase , Autophagy
T3803	Specnuezhenide	Nuzhenide,Nuezhenide	Others , NF-κB , Wnt/beta-catenin
	Specnuezhenide (Nuezhenide) significantly protects human neuroblastoma SH-SY5Y cells from 6-hydroxydopamine-induced neurotoxicity.Nuezhenide is the main inhibitory compound of fruits, it shows a clear inhibitory effect t...		Others , NF-κB , Wnt/beta-catenin
T6S1049	Wilforine		ATPase
	Wilforine is a sesquiterpene pyridine alkaloid; important bioactive compound in T. wilfordii plants, and is effective in treating idiopathic pulmonary fibrosis. Wilforine has anti-inflammatory effect, which might be medi...		ATPase
T4S1422	Praeruptorin E		Others , Calcium Channel
	1. Praeruptorin C and E can relax swine coronary artery and decrease contractility in guinea-pig left atria, these effects are similar in many respects to those displayed by drugs that have calcium entry blocking activit...		Others , Calcium Channel
T4115	Auraptene	7-geranyloxycoumarin	MMP , BACE
	Auraptene is a coumarin derived from citrus plants that bears a geranyloxyl moiety at its C-7. It has anti-inflammatory, anti-carcinogenic, anti-bacterial, neuroprotective, and hepatoprotective activities. It inhibits le...		MMP , BACE
T3744	Veratric acid	Veratrumenoic acid,3,4-Dimethoxybenzoic acid	Reactive Oxygen Species , COX
	Veratric acid (3,4-Dimethoxybenzoic acid) is a simple benzoic acid derived from plants and fruits with anti-oxidant, anti-inflammation and blood pressure-lowering effects.		Reactive Oxygen Species , COX
T6S1917	Schisandrol B	Gomisin A,TJN-101,Besigomsin,Gamma-Schisandrin,Schizandrol B,Wuweizi alcohol-B	P450 , Reactive Oxygen Species , Autophagy
	1. Schisandrol B (Besigomsin) may exert neuroprotective effects by attenuating the microglia-mediated neuroinflammatory response via inhibiting the TLR4-mediated NF-κB and MAPKs signaling pathways. 2. Schisandrol B has a...		P450 , Reactive Oxygen Species , Autophagy
T2S0843	Negletein	7-O-Methylbaicalein,Baicalein-7-methylether	IL Receptor , TNF , NOS , Interleukin
	1. Negletein (7-O-Methylbaicalein) has anti-inflammatory and immunomodulatory activities via inhibition of TNF-α, iNOS and IL-1β. 2. Negletein as a neuroprotectant enhances the action of nerve growth factor and induces n...		IL Receptor , TNF , NOS , Interleukin
T6S1141	Ganoderic acid A		Apoptosis , NF-κB , Endogenous Metabolite , Autophagy
	1. Ganoderic acid A exhibits antitumor activity, mediated through its inhibitory effect on nuclear transcription factor-kappaB and activator protein-1. 2. Ganoderic acid A can induce proliferation inhibition, apoptosis a...		Apoptosis , NF-κB , Endogenous Metabolite , Autophagy
T2S2264	Linalool	Linalol,(±)-Linalool,Phantol	Apoptosis , IL Receptor , TNF , Endogenous Metabolite , iGluR
	1. Linalool (Linalol), a natural compound of the essential oils, has been shown to have antinociceptive, antimicrobial, and anti-inflammatory properties. 2. Linalool was protected against LPS/GalN-induced liver injury th...
T5558	Chelidonic acid	Jervaic acid,Jerva acid,γ-Pyrone-2,6-dicarboxylic acid	NF-κB , Caspase
	Chelidonic acid (Jervaic acid) is a component of Chelidonium majus L., used as a mild analgesic, an antimicrobial, an acentral nervous system sedative. Chelidonic acid (Jervaic acid) also shows anti-inflammatory activity...		NF-κB , Caspase
T3893	Forsythoside B		TNF , NF-κB
	Forsythoside B binds to LPS and reduces the biological activity of serum LPS, and inhibits NF-κB activation. Forsythoside B inhibits the inflammatory response and has antioxidant properties. Potent neuroprotective effect...		TNF , NF-κB
T26545	Acanthoic acid	NP1302,NP 1302: NP-1302
	Acanthoic acid is a pimaradiene diterpene isolated from Acanthopanax koreanum with anti-inflammatory activities. Acanthoic acid downregulates LPS-induced IL-1β, IL-6 and TNF-α production in BALF, attenuates lung histopat...
TN1458	Buddlejasaponin IV		PARP , Akt , Chk
	Buddlejasaponin IV has analgesic and anti-inflammatory effects, the inhibitions of the expressions of iNOS, COX-2, TNF-alpha, IL-1beta and IL-6 by blocking NF-kappaB activation.		PARP , Akt , Chk
T11034	Di-O-methyldemethoxycurcumin		IL Receptor
	Di-O-methyldemethoxycurcumin is a Curcumin analog isolated from medicinal plant turmeric di-orthomethyldemethoxycurcumin, anti-inflammatory and antioxidant properties Inhibition of IL-6 production, EC50 is 16.20μg/mL.		IL Receptor
T75674	Pedunculagin
	Pedunculagin, a potent 5α-reductase type 1 inhibitor, effectively inhibits the production of nitric oxide (NO), IL-6, and IL-8 while also decreasing the protein expression of 5α-reductase. Additionally, it exhibits anti-...
TMA2576	Episappanol		IL Receptor , TNF
	Episappanol has anti-inflammatory activity , it can significantly inhibit the secretion of the pro-inflammatory cytokines interleukin (IL-6) and tumor necrosis factor-alpha (TNF-α).		IL Receptor , TNF
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天然物製品

Angoline

TN6739

Synonym: 6-Methoxyldihydrochelerythrine

Target: IL Receptor, STAT

Terminolic acid

TN6722

Synonym: 2α,6β,23-trihydroxyl oleanolic acid

Target: Antibacterial

Muscone

T2893

Synonym: 3-Methylcyclopentadecanone,Methylexaltone

Target: MMP, TNF, NF-κB, NOD-like Receptor (NLR), P-gp, Interleukin

Isoforskolin

TN1520

Synonym: Coleonol B

Target: IL Receptor, TNF

Kansuinine B

T40660

Synonym:

Target: IL Receptor, SARS-CoV

Synonym: 14-deoxyandrographolide

Target: IL Receptor, TNF

Umbelliprenin

TN6778

Synonym: 7-[[(2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrienyl]oxy]-2H-1-benzopyran-2-oneUmbelliprenin

Target: IL Receptor, STAT, Interleukin

Estradiol

T1048

Synonym: E2,17β-Estradiol,17β-Oestradiol,β-Estradiol

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Endogenous Metabolite

Nepetin

TN1154

Synonym: 6-Methoxyluteolin

Target: Calcium Channel, Histamine Receptor

Mulberroside A

T6S1597

Synonym:

Target: TNF, Tyrosinase, Interleukin

Neobavaisoflavone

T6S0139

Synonym:

Target: Apoptosis, DNA/RNA Synthesis

Liriope muscari baily saponins C

Target: Apoptosis, Others, NO Synthase, Prostaglandin Receptor, Interleukin

Corylifol A

T4S0145

Synonym: Corylinin

Target: hCE, STAT, UGT

alpha-Cyperone

T5S1981

Synonym: (+)-α-Cyperone,α-Cyperone

Target: Others, Endogenous Metabolite

Ginsenoside Rh1

T2932

Synonym: Sanchinoside B2,Prosapogenin A2,20(S)-Ginsenoside Rh1,Sanchinoside Rh1

Target: IL Receptor, TNF, Endogenous Metabolite, PPAR, Interleukin

Madecassic acid

T2758

Synonym: 6-Deoxy-L-Galactose,L-Fucose,Brahmic acid,L-fucopyranose

Target: Others, TNF, COX, NO Synthase, Interleukin

Guanosine 5'-diphosphate

T7210

Synonym: GDP

Target: Endogenous Metabolite

Velutin

T3816

Synonym:

Target: NF-κB, HIF/HIF Prolyl-Hydroxylase

α-Terpineol

Fr14115

Synonym: Terpineol

Target: IL Receptor, Anti-infection, Antibacterial

Sodium Thiocyanate

T8033

Synonym:

Target: Others, Reactive Oxygen Species, Interleukin

6-Demethoxytangeretin

Target: IL Receptor, TNF, TLR, JAK, STAT

Triamcinolone

T0798

Synonym: Fluoxyprednisolone,Aristocort,Rodinolone

Target: Glucocorticoid Receptor, COX

Tricetin

TN5171

Synonym:

Target: Apoptosis, Others, Nrf2

Echinatin

T3926

Synonym: Retrochalcone

Target: Free radical scavengers

Icaritin

T3398

Synonym: Anhydroicaritin,Cycloicaritin

Target: Apoptosis, JAK, STAT, Autophagy

Tetrahydrocoptisine

T4S2063

Synonym: STYLOPINE

Target: ERK, p38 MAPK, NF-κB

4-Methylesculetin

TJS0338

Synonym: 4-Methyl-6,7-dihydroxycoumarin,Methylesculetin

Target: Antioxidant, Glutathione Peroxidase

Oroxylin A

T6S1315

Synonym: 6-Methoxybaicalein,Baicalein 6-methyl ether

Target: Virus Protease, HIF/HIF Prolyl-Hydroxylase, Autophagy

Specnuezhenide

T3803

Synonym: Nuzhenide,Nuezhenide

Target: Others, NF-κB, Wnt/beta-catenin

Target: Others, Calcium Channel

Auraptene

T4115

Synonym: 7-geranyloxycoumarin

Target: MMP, BACE

Veratric acid

T3744

Synonym: Veratrumenoic acid,3,4-Dimethoxybenzoic acid

Target: Reactive Oxygen Species, COX

Schisandrol B

T6S1917

Synonym: Gomisin A,TJN-101,Besigomsin,Gamma-Schisandrin,Schizandrol B,Wuweizi alcohol-B

Target: P450, Reactive Oxygen Species, Autophagy

Negletein

T2S0843

Synonym: 7-O-Methylbaicalein,Baicalein-7-methylether

Target: IL Receptor, TNF, NOS, Interleukin

Ganoderic acid A

T6S1141

Synonym:

Target: Apoptosis, NF-κB, Endogenous Metabolite, Autophagy

Linalool

T2S2264

Synonym: Linalol,(±)-Linalool,Phantol

Target: Apoptosis, IL Receptor, TNF, Endogenous Metabolite, iGluR

Chelidonic acid

T5558

Synonym: Jervaic acid,Jerva acid,γ-Pyrone-2,6-dicarboxylic acid

Target: NF-κB, Caspase

Synonym: NP1302,NP 1302: NP-1302

Target: PARP, Akt, Chk

Di-O-methyldemethoxycurcumin

Target: IL Receptor, TNF

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Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-03238	IL-6 Protein, Mouse, Recombinant	Mouse	E. coli
	Interleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, which is known particularly for its role in the immune response and acute phase reactions. I...
TMPY-00863	IL-6 Protein, Human, Recombinant	Human	E. coli
	Interleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, which is known particularly for its role in the immune response and acute phase reactions. I...
TMPY-05278	IL-6R Protein, Human, Recombinant (hFc)	Human	HEK293
	Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (SIL-6R) acts as an agonist of IL-6 activity. In...
TMPY-00864	IL-6R Protein, Human, Recombinant (His)	Human	HEK293
	Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (SIL-6R) acts as an agonist of IL-6 activity. In...
TMPY-01214	IL-6R Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (SIL-6R) acts as an agonist of IL-6 activity. In...
TMPY-03327	IL-6 Protein, Rhesus, Recombinant	Rhesus	E. coli
	Interleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, which is known particularly for its role in the immune response and acute phase reactions. I...
TMPY-03298	IL-6 Protein, Rat, Recombinant	Rat	E. coli
	Interleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, which is known particularly for its role in the immune response and acute phase reactions. I...
TMPY-03802	IL-17F Protein, Human, Recombinant (aa 31-163)	Human	E. coli
	Interleukin-17F (IL-17F) is a cytokine that shares sequence similarity with IL17. The most notable role of IL-17 is its involvement in inducing and mediating proinflammatory responses. IL-17 is commonly associated with a...
TMPY-01076	Gp130/IL6ST Protein, Human, Recombinant (His & hFc)	Human	HEK293
	Glycoprotein 130 (also known as gp130, IL6ST, IL6-beta, or CD130) is a transmembrane protein that is the founding member of the class of all cytokine receptors. CD130/gp130 is a signal transducer shared by many cytokines...
TMPK-00101	IL-6 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
	IL-6 (Interleukin-6) is a pleiotropic cytokine that acts in the acute phase reaction, inflammation, hematopoiesis, bone metabolism, and cancer progression.Interleukin 6 has been shown to interact with interleukin-6 recep...
TMPY-02879	IL-36 alpha/IL-1F6 Protein, Human, Recombinant (aa 6-158)	Human	E. coli
	Interleukin-1 family member 6 (IL-1F6), also known as interleukin 36, alpha (IL36A), is a pro-inflammatory cytokine that plays an important role in innate and adaptive immunity. IL-1F6 activates MAPK and NF-kB pathways a...
TMPY-02603	STAT6 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	Signal transducer and activator of transcription 6 (STAT6) is a transcription factor that is activated by interleukin-4 (IL-4)-induced tyrosine phosphorylation and mediates most of the IL-4-induced gene expression. STAT6...
TMPK-00646	Gp130/IL6ST Protein, Rhesus macaque, Recombinant (His)	Rhesus macaque	HEK293
	gp130 is a common signal transducing component of the functional receptor complexes for the interleukin (IL)-6 family of cytokines, ie, IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M, ciliary neurotrophic fa...
TMPK-00412	Gp130/IL6ST Protein, Human, Recombinant (His)	Human	HEK293
	gp130 is a common signal transducing component of the functional receptor complexes for the interleukin (IL)-6 family of cytokines, ie, IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M, ciliary neurotrophic fa...
TMPY-06297	IL-6R Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
	Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (SIL-6R) acts as an agonist of IL-6 activity. In...
TMPY-05640	IL-6R Protein, Human, Recombinant, Biotinylated	Human	HEK293
	Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (SIL-6R) acts as an agonist of IL-6 activity. In...
TMPJ-00291	IL-6R alpha/CD126 Protein, Human, Recombinant (Avi & His), Biotinylated	Human	Human Cells
	Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. IL6Ra is a part of the receptor for interleukin 6 cytokine. IL6Ra binds to...
TMPK-00042	IL-17F Protein, Mouse, Recombinant (His & Avi), Biotinylated	Mouse	HEK293
	The Interleukin 17 (IL-17) family proteins, comprising six members (IL-17A through IL-17F), are secreted, structurally related proteins that share a conserved cystine-knot fold near the C-terminus, but have considerable ...
TMPK-00041	IL-17F Protein, Mouse, Recombinant (His & Avi)	Mouse	HEK293
	The Interleukin 17 (IL-17) family proteins, comprising six members (IL-17A through IL-17F), are secreted, structurally related proteins that share a conserved cystine-knot fold near the C-terminus, but have considerable ...
TMPK-00046	IL-17F Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
	The Interleukin 17 (IL-17) family proteins, comprising six members (IL-17A through IL-17F), are secreted, structurally related proteins that share a conserved cystine-knot fold near the C-terminus, but have considerable ...
TMPJ-00194	IL-20RB Protein, Human, Recombinant (hFc)	Human	Human Cells
	Interleukin-20 receptor subunit beta（IL20RB） is a single-pass type I membrane protein and belongs to the type II cytokine receptor family. It contains 2 fibronectin type-III domains. There are two kinds of type II cytoki...
TMPY-05461	IL-17F Protein, Human, Recombinant (His), Biotinylated	Human	HEK293
	Interleukin-17F (IL-17F) is a cytokine that shares sequence similarity with IL17. The most notable role of IL-17 is its involvement in inducing and mediating proinflammatory responses. IL-17 is commonly associated with a...
TMPY-06039	Gp130/IL6ST Protein, Human, Recombinant (aa 1-618, DDDDK)	Human	HEK293
	Glycoprotein 130 (also known as gp130, IL6ST, IL6-beta, or CD130) is a transmembrane protein that is the founding member of the class of all cytokine receptors. CD130/gp130 is a signal transducer shared by many cytokines...
TMPY-01898	IL-17F Protein, Human, Recombinant (aa 31-163, His)	Human	HEK293
	Interleukin-17F (IL-17F) is a cytokine that shares sequence similarity with IL17. The most notable role of IL-17 is its involvement in inducing and mediating proinflammatory responses. IL-17 is commonly associated with a...
TMPY-00387	Gp130/IL6ST Protein, Human, Recombinant (hFc)	Human	HEK293
	Glycoprotein 130 (also known as gp130, IL6ST, IL6-beta, or CD130) is a transmembrane protein that is the founding member of the class of all cytokine receptors. CD130/gp130 is a signal transducer shared by many cytokines...
TMPY-06745	Gp130/IL6ST Protein, Human, Recombinant (mFc)	Human	HEK293
	Glycoprotein 130 (also known as gp130, IL6ST, IL6-beta, or CD130) is a transmembrane protein that is the founding member of the class of all cytokine receptors. CD130/gp130 is a signal transducer shared by many cytokines...
TMPK-00289	IL-6R alpha/CD126 Protein, Human, Recombinant (His & Avi)	Human	HEK293
	The multifunctional factor interleukin 6 (IL-6) exerts its activities through binding to a high-affinity receptor complex consisting of two membrane glycoproteins: an 80 kDa component receptor that binds IL-6 with low af...
TMPY-05559	IL-20RB Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	IL20RB belongs to the type II cytokine receptor family. There are two kinds of type II cytokine receptors: cytokine receptors that bind type I and type II interferons; cytokine receptors that bind members of the interleu...
TMPH-03208	IL-6 Protein, Rabbit, Recombinant (His)	Rabbit	Yeast
	Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-sign...
TMPH-03500	IL-6 Protein, Sheep, Recombinant (GST)	Sheep	E. coli
	Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-sign...
TMPY-04183	IL-6 Protein, Sus scrofa (Pig), Recombinant	Sus scrofa (Pig)	E. coli
	Interleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, which is known particularly for its role in the immune response and acute phase reactions. I...
TMPJ-00035	IL-4 Protein, Human, Recombinant (His)	Human	Human Cells
	Interleukin-4 (IL-4) is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. IL-4 is produced by mast cells, T cells, and bone marrow stromal ce...
TMPY-03142	IL-27 Protein, Human, Recombinant (His)	Human	CHO
	IL-27 protein is a member of the IL-6 superfamily, which is expressed on monocytes, endothelial cells, and dendritic cells. IL-27 protein is also referred to as the IL-12 p35-related protein, p28, is one subunit of a het...
TMPY-03153	IL-27 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	IL-27 protein is a member of the IL-6 superfamily, which is expressed on monocytes, endothelial cells, and dendritic cells. IL-27 protein is also referred to as the IL-12 p35-related protein, p28, is one subunit of a het...
TMPY-00854	IL-1 alpha/IL-1A Protein, Human, Recombinant	Human	HEK293
	IL-1 alpha is a member of the interleukin 1 cytokine family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proli...
TMPJ-01172	IL-17 Protein, Mouse, Recombinant (His)	Mouse	Human Cells
	Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. Mature mouse IL-17A shares 61% and 89% amino acid seque...
TMPJ-00890	IL-13 Protein, Mouse, Recombinant (aa 26-131, His)	Mouse	Human Cells
	Mouse interleukin 13 (mIL-13) is a pleiotropic cytokine produced by activated Th2 cells. IL-13 induces B cell proliferation and immunoglobin production. It contains a four helical bundle with two internal disulfide bonds...
TMPY-01738	IL-1 alpha/IL-1A Protein, Mouse, Recombinant	Mouse	E. coli
	IL-1 alpha is a member of the interleukin 1 cytokine family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proli...
TMPY-06981	IL-1 alpha/IL-1A Protein, Human, Recombinant (E. coli)	Human	E. coli
	IL-1 alpha is a member of the interleukin 1 cytokine family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proli...
TMPJ-00889	IL-13 Protein, Mouse, Recombinant (aa 22-131, His)	Mouse	Human Cells
	Mouse interleukin 13 (mIL-13) is a pleiotropic cytokine produced by activated Th2 cells. IL-13 induces B cell proliferation and immunoglobin production. It contains a four helical bundle with two internal disulfide bonds...
TMPY-00856	TCCR Protein, Human, Recombinant (hFc)	Human	HEK293
	The interleukin-27 receptor is a type I cytokine receptor for interleukin-27. It is a heterodimer composed of the interleukin 27 receptor, alpha subunit, and glycoprotein 130. WSX-1/IL-27R, a class I cytokine receptor th...
TMPY-01305	OSMR Protein, Human, Recombinant (His)	Human	HEK293
	Oncostatin-M specific receptor subunit beta also known as the oncostatin M receptor (OSMR) and Interleukin-31 receptor subunit beta (IL-31RB), is one of the receptor proteins for oncostatin M. OSMR is a member of the typ...
TMPY-02335	OSMR Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Oncostatin-M specific receptor subunit beta also known as the oncostatin M receptor (OSMR) and Interleukin-31 receptor subunit beta (IL-31RB), is one of the receptor proteins for oncostatin M. OSMR is a member of the typ...
TMPJ-01467	Oncostatin M/OSM Protein, Human, Recombinant (E. coli, His)	Human	E.coli
	Oncostatin M (OSM) is a glycoprotein belonging to the interleukin-6 family of cytokines that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. OSM encodes a growth regulator, ...
TMPY-04104	LIF Protein, Human, Recombinant	Human	HEK293
	Leukemia inhibitory factor (LIF) is a pleiotropic glycoprotein belonging to the IL-6 family of cytokines. It is involved in growth promotion and cell differentiation of different types of target cells, influence bone met...
TMPY-04278	LIF Protein, Mouse, Recombinant	Mouse	HEK293
	Leukemia inhibitory factor (LIF) is a pleiotropic glycoprotein belonging to the IL-6 family of cytokines. It is involved in growth promotion and cell differentiation of different types of target cells, influence bone met...
TMPY-03532	LIF Protein, Human, Recombinant (His)	Human	HEK293
	Leukemia inhibitory factor (LIF) is a pleiotropic glycoprotein belonging to the IL-6 family of cytokines. It is involved in growth promotion and cell differentiation of different types of target cells, influence bone met...
TMPY-01107	TIMP-1 Protein, Human, Recombinant	Human	HEK293
	TIMP metallopeptidase inhibitor 1, also known as TIMP-1/TIMP1, Collagenase inhibitor 16C8 fibroblast Erythroid-potentiating activity, TPA-S1TPA-induced proteinTissue inhibitor of metalloproteinases 1, is a natural inhibi...
TMPY-04859	IL-6R Protein, Rhesus, Recombinant (His)	Rhesus	HEK293
	Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (SIL-6R) acts as an agonist of IL-6 activity. In...
TMPY-04187	IL-6R Protein, Rat, Recombinant (hFc)	Rat	HEK293
	Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (SIL-6R) acts as an agonist of IL-6 activity. In...
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IL-6 Protein, Mouse, Recombinant

TMPY-03238

Species: Mouse

Expression System: E. coli

IL-6 Protein, Human, Recombinant

TMPY-00863

Species: Human

Expression System: E. coli

IL-6R Protein, Human, Recombinant (hFc)

TMPY-05278

Species: Human

Expression System: HEK293

IL-6R Protein, Human, Recombinant (His)

TMPY-00864

Species: Human

Expression System: HEK293

IL-6R Protein, Mouse, Recombinant (His)

TMPY-01214

Species: Mouse

Expression System: HEK293

IL-6 Protein, Rhesus, Recombinant

TMPY-03327

Species: Rhesus

Expression System: E. coli

IL-6 Protein, Rat, Recombinant

TMPY-03298

Species: Rat

Expression System: E. coli

IL-17F Protein, Human, Recombinant (aa 31-163)

TMPY-03802

Species: Human

Expression System: E. coli

gp130/IL6ST Protein, Human, Recombinant (His & hFc)

TMPY-01076

Species: Human

Expression System: HEK293

IL-6 Protein, Cynomolgus, Recombinant (His)

TMPK-00101

Species: Cynomolgus

Expression System: HEK293

IL-36 alpha/IL-1F6 Protein, Human, Recombinant (aa 6-158)

TMPY-02879

Species: Human

Expression System: E. coli

STAT6 Protein, Human, Recombinant (His)

TMPY-02603

Species: Human

Expression System: Baculovirus-Insect Cells

gp130/IL6ST Protein, Rhesus macaque, Recombinant (His)

TMPK-00646

Species: Rhesus macaque

Expression System: HEK293

gp130/IL6ST Protein, Human, Recombinant (His)

TMPK-00412

Species: Human

Expression System: HEK293

IL-6R Protein, Human, Recombinant (His & Avi), Biotinylated

TMPY-06297

Species: Human

Expression System: HEK293

IL-6R Protein, Human, Recombinant, Biotinylated

TMPY-05640

Species: Human

Expression System: HEK293

IL-6R alpha/CD126 Protein, Human, Recombinant (Avi & His), Biotinylated

TMPJ-00291

Species: Human

Expression System: Human Cells

IL-17F Protein, Mouse, Recombinant (His & Avi), Biotinylated

TMPK-00042

Species: Mouse

Expression System: HEK293

IL-17F Protein, Mouse, Recombinant (His & Avi)

TMPK-00041

Species: Mouse

Expression System: HEK293

IL-17F Protein, Human, Recombinant (His & Avi), Biotinylated

TMPK-00046

Species: Human

Expression System: HEK293

IL-20RB Protein, Human, Recombinant (hFc)

TMPJ-00194

Species: Human

Expression System: Human Cells

IL-17F Protein, Human, Recombinant (His), Biotinylated

TMPY-05461

Species: Human

Expression System: HEK293

gp130/IL6ST Protein, Human, Recombinant (aa 1-618, DDDDK)

TMPY-06039

Species: Human

Expression System: HEK293

IL-17F Protein, Human, Recombinant (aa 31-163, His)

TMPY-01898

Species: Human

Expression System: HEK293

gp130/IL6ST Protein, Human, Recombinant (hFc)

TMPY-00387

Species: Human

Expression System: HEK293

gp130/IL6ST Protein, Human, Recombinant (mFc)

TMPY-06745

Species: Human

Expression System: HEK293

IL-6R alpha/CD126 Protein, Human, Recombinant (His & Avi)

TMPK-00289

Species: Human

Expression System: HEK293

IL-20RB Protein, Human, Recombinant (His)

TMPY-05559

Species: Human

Expression System: Baculovirus-Insect Cells

IL-6 Protein, Rabbit, Recombinant (His)

TMPH-03208

Species: Rabbit

Expression System: Yeast

IL-6 Protein, Sheep, Recombinant (GST)

TMPH-03500

Species: Sheep

Expression System: E. coli

IL-6 Protein, Sus scrofa (Pig), Recombinant

TMPY-04183

Species: Sus scrofa (Pig)

Expression System: E. coli

IL-4 Protein, Human, Recombinant (His)

TMPJ-00035

Species: Human

Expression System: Human Cells

IL-27 Protein, Human, Recombinant (His)

TMPY-03142

Species: Human

Expression System: CHO

IL-27 Protein, Mouse, Recombinant (His)

TMPY-03153

Species: Mouse

Expression System: HEK293

IL-1 alpha/IL-1A Protein, Human, Recombinant

TMPY-00854

Species: Human

Expression System: HEK293

IL-17 Protein, Mouse, Recombinant (His)

TMPJ-01172

Species: Mouse

Expression System: Human Cells

IL-13 Protein, Mouse, Recombinant (aa 26-131, His)

TMPJ-00890

Species: Mouse

Expression System: Human Cells

IL-1 alpha/IL-1A Protein, Mouse, Recombinant

TMPY-01738

Species: Mouse

Expression System: E. coli

IL-1 alpha/IL-1A Protein, Human, Recombinant (E. coli)

TMPY-06981

Species: Human

Expression System: E. coli

IL-13 Protein, Mouse, Recombinant (aa 22-131, His)

TMPJ-00889

Species: Mouse

Expression System: Human Cells

TCCR Protein, Human, Recombinant (hFc)

TMPY-00856

Species: Human

Expression System: HEK293

OSMR Protein, Human, Recombinant (His)

TMPY-01305

Species: Human

Expression System: HEK293

OSMR Protein, Mouse, Recombinant (His)

TMPY-02335

Species: Mouse

Expression System: HEK293

Oncostatin M/OSM Protein, Human, Recombinant (E. coli, His)

TMPJ-01467

Species: Human

Expression System: E.coli

LIF Protein, Human, Recombinant

TMPY-04104

Species: Human

Expression System: HEK293

LIF Protein, Mouse, Recombinant

TMPY-04278

Species: Mouse

Expression System: HEK293

LIF Protein, Human, Recombinant (His)

TMPY-03532

Species: Human

Expression System: HEK293

TIMP-1 Protein, Human, Recombinant

TMPY-01107

Species: Human

Expression System: HEK293

IL-6R Protein, Rhesus, Recombinant (His)

TMPY-04859

Species: Rhesus

Expression System: HEK293

IL-6R Protein, Rat, Recombinant (hFc)

TMPY-04187

Species: Rat

Expression System: HEK293

--------- More ---------

カタログ番号	製品名
L3800	NF-κB Signaling Compound Library	729 compounds
	A unique collection of 729 compounds targeting NF-κB signaling for high throughput screening and high content screening;
L7600	Chemokine Inhibitor Library	59 compounds
	A unique collection of 59 chemokines or chemokine receptors targeted compounds for high throughput and high content screening;

ライブラリー

NF-κB Signaling Compound Library

L3800

Compounds: 729

Chemokine Inhibitor Library

L7600

Compounds: 59