Powder: -20°C for 3 years | In solvent: -80°C for 1 year
N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(N-ethylcyclopropanecarboxamido)-4-methyl-4′-morpholino-[1,1′-biphenyl]-3-carboxamide is a potent and selective Enhancer of Zeste Homolog 2 (EZH2) inhibitor with IC50 0f 37.6 nM and 79.1 nM for EZH2 WT and EZH2-Y641F, respectively.
説明 | N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(N-ethylcyclopropanecarboxamido)-4-methyl-4′-morpholino-[1,1′-biphenyl]-3-carboxamide is a potent and selective Enhancer of Zeste Homolog 2 (EZH2) inhibitor with IC50 0f 37.6 nM and 79.1 nM for EZH2 WT and EZH2-Y641F, respectively. |
In vitro | N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(N-ethylcyclopropanecarboxamido)-4-methyl-4′-morpholino-[1,1′-biphenyl]-3-carboxamide exhibits antiproliferative effects against the WSU-DLCL2 cell line with GI50 of 0.2 μM. |
分子量 | 542.67 |
分子式 | C32H38N4O4 |
CAS No. | 2238820-26-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10 mg/mL (18.43 mM)
You can also refer to dose conversion for different animals. 詳細
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N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(N-ethylcyclopropanecarboxamido)-4-methyl-4′-morpholino-[1,1′-biphenyl]-3-carboxamide 2238820-26-1 Chromatin/Epigenetic Histone Methyltransferase N((4,6dimethyl2oxo1,2dihydropyridin3yl)methyl)5(Nethylcyclopropanecarboxamido)4methyl4′morpholino[1,1′biphenyl]3carboxamide Inhibitor inhibitor inhibit