Powder: -20°C for 3 years | In solvent: -80°C for 1 year
3-aminopropylphosphonic acid (3-APPA) is a phosphonic analog of GABA that acts as a partial agonist of GABAB receptors (IC50 = 1.5 μM in a radioligand binding assay).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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5 mg | 在庫あり | ¥ 9,500 | |||
10 mg | 在庫あり | ¥ 13,000 | |||
25 mg | 在庫あり | ¥ 21,000 | |||
50 mg | 在庫あり | ¥ 30,000 | |||
100 mg | 在庫あり | ¥ 45,500 | |||
500 mg | 在庫あり | ¥ 114,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 9,500 |
説明 | 3-aminopropylphosphonic acid (3-APPA) is a phosphonic analog of GABA that acts as a partial agonist of GABAB receptors (IC50 = 1.5 μM in a radioligand binding assay). |
In vitro | 3-aminopropylphosphonic acid (IC50 1.5 microM) and 4-aminobutyl-phosphonic acid (IC50 3.9 μM) were much more potent than anticipated from their relatively weak GABAB antagonist actions [1]. 3-aminopropylphosphonic acid was a potent inhibitor (IC50 6μM) of the binding of [3H]GABA to rat brain membranes under GABAB conditions, i.e. in the presence of 0.1 mM isoguvacine and displaceable by 0.1 mM (+)-baclofen [1]. |
In vivo | 3-aminopropylphosphonic acid induces relaxation in unstimulated isolated guinea pig ileum longitudinal muscle and reverses GABA- and baclofen-induced inhibition of twitch responses in isolated guinea pig ileum longitudinal muscle. 3-APPA (5 mg/kg) completely inhibits GABA- and baclofen-induced inhibition of vagally stimulated bronchospasms in guinea pigs. It also reverses the antitussive effect of baclofen in cats when administered at a dose of 3 mg/kg. |
分子量 | 139.09 |
分子式 | C3H10NO3P |
CAS No. | 13138-33-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/mL
DMF: 5 mg/mL
DMSO: < 1mg/ml (insoluble)
Ethanol: 30 mg/mL
You can also refer to dose conversion for different animals. 詳細
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3-Aminopropylphosphonic Acid 13138-33-5 Membrane transporter/Ion channel Neuroscience GABA Receptor 3Aminopropylphosphonic Acid 3 Aminopropylphosphonic Acid Inhibitor inhibitor inhibit