Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AZD6280 is a novel, subtype-selective GABAAα2/3 receptor positive modulators, used for treatment of generalized anxiety disorder.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 68,500 |
5 mg | 在庫あり | ¥ 137,000 |
10 mg | 在庫あり | ¥ 195,500 |
25 mg | 在庫あり | ¥ 296,000 |
50 mg | 在庫あり | ¥ 397,000 |
100 mg | 在庫あり | ¥ 539,500 |
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 151,000 |
説明 | AZD6280 is a novel, subtype-selective GABAAα2/3 receptor positive modulators, used for treatment of generalized anxiety disorder. |
In vivo | The [11C]flumazenil binding was reduced in a dose-dependent, saturable manner by AZD6280. Maximum receptor occupancy could be reached for AZD6280 without causing sedation or cognitive impairment. The K i,plasma estimates for AZD6280 was 440 nmol/l[1]. |
動物実験 | Two PET studies, using high-resolution research tomography (HRRT) and the radioligand [11C]flumazenil, were performed in 12 subjects at baseline and after administration of single oral doses of AZD7325 (0.2 to 30 mg) and AZD6280 (5 to 40 mg). PET images were analyzed using a simplified reference tissue model, and regional binding potentials (BPND) were obtained. The relationship between plasma concentration of AZD7325 or AZD6280 and GABAA receptor occupancy was described by hyperbolic function, and K i,plasma (plasma concentration required for 50% receptor occupancy) was estimated. Assessments of safety and tolerability included recording of adverse events, vital signs, electrocardiogram, and laboratory tests[1]. |
分子量 | 366.41 |
分子式 | C20H22N4O3 |
CAS No. | 942436-93-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (68.23 mM)
You can also refer to dose conversion for different animals. 詳細
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AZD-6280 942436-93-3 Membrane transporter/Ion channel Neuroscience GABA Receptor γ-Aminobutyric acid Receptor inhibit Gamma-aminobutyric acid Receptor Inhibitor AZD 6280 AZD6280 inhibitor