Powder: -20°C for 3 years | In solvent: -80°C for 1 year
6-(γ,γ-Dimethylallylamino)purine (Triacanthine), which is a plant growth substance, shows hypertensive and antitumor activity, also cardiotonic, antispasmodic and a respiratory analeptic.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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100 mg | 在庫あり | ¥ 9,500 | |||
500 mg | 在庫あり | ¥ 15,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 10,500 |
説明 | 6-(γ,γ-Dimethylallylamino)purine (Triacanthine), which is a plant growth substance, shows hypertensive and antitumor activity, also cardiotonic, antispasmodic and a respiratory analeptic. |
In vitro | Triacanthine significantly inhibited EJ cell proliferation (IC50 600?μM). Flow cytometry analysis revealed that cells were arrested in the G1 phase, and apoptotic cells accumulated in the sub-G1 phase in a dose-dependent manner. Triacanthine inhibited the G1-S transition by deterring complex formation between cyclin-dependent kinases and cyclins, thereby up-regulating cell cycle inhibitors p21WAF1 and p27KIP1. |
In vivo | In an in vivo study, triacanthine significantly limited growth of xenografted tumors. Interestingly, while cisplatin resulted in significant weight loss after a 5-mg/kg dose, triacanthine did not cause weight loss, behavioral abnormalities, altered biochemical parameters, or tissue staining. A single oral dose acute-toxicity test (triacanthine 2,000?mg/kg) produced no adverse cytotoxic effects via blood biochemical tests and tissue-organ staining. |
植物由来 |
別名 | N6-(2-lsopentenyl)adenine, Triacanthine |
分子量 | 203.24 |
分子式 | C10H13N5 |
CAS No. | 2365-40-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 2.03 mg/mL (10 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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6-(γ,γ-Dimethylallylamino)purine 2365-40-4 Others 6-(r,r-Dimethylallylamino)purine N6-(2-lsopentenyl)adenine 6(γ,γDimethylallylamino)purine inhibit Triacanthine 6 (γ,γ Dimethylallylamino)purine Inhibitor 6-(gamma,gamma-Dimethylallylamino)purine inhibitor