Powder: -20°C for 3 years | In solvent: -80°C for 1 year
6-Mercaptopurine (6-MP) is an antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
25 mg | 在庫あり | ¥ 7,500 | |||
50 mg | 在庫あり | ¥ 10,500 | |||
100 mg | 在庫あり | ¥ 15,500 | |||
500 mg | 在庫あり | ¥ 19,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 11,500 |
説明 | 6-Mercaptopurine (6-MP) is an antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia. |
In vivo | Phosphoribosyl pyrophosphate amidotransferase acts as the rate-limiting enzyme in purine biosynthesis, affecting the synthesis and function of RNA and DNA. Mercaptopurine inhibits this enzyme, thereby hindering purine nucleoside and its metabolism, which interferes with nucleotide interconversion and glycoprotein synthesis. |
別名 | 6-MP, Mercaptopurine |
分子量 | 152.18 |
分子式 | C5H4N4S |
CAS No. | 50-44-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 7.5 mg/mL (49.28 mM), Sonication is recommended.
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
H2O: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. 詳細
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6-Mercaptopurine 50-44-2 Autophagy Cell Cycle/Checkpoint DNA Damage/DNA Repair Metabolism Others Dehydrogenase Nucleoside Antimetabolite/Analog Endogenous Metabolite Inhibitor 6 Mercaptopurine 6-MP 6Mercaptopurine Mercaptopurine inhibit inhibitor