Powder: -20°C for 3 years | In solvent: -80°C for 1 year
A-582941 is a alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing properties
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 30,500 | |||
5 mg | 在庫あり | ¥ 69,500 | |||
10 mg | 在庫あり | ¥ 104,000 | |||
25 mg | 在庫あり | ¥ 171,500 | |||
50 mg | 在庫あり | ¥ 241,000 | |||
100 mg | 在庫あり | ¥ 326,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 68,500 |
説明 | A-582941 is a alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing properties |
In vitro | A-582941 was found to exhibit high-affinity binding and partial agonism at alpha7 nAChRs, with acceptable pharmacokinetic properties and excellent distribution to the central nervous system (CNS).?In vitro and in vivo studies indicated that A-582941 activates signaling pathways known to be involved in cognitive function such as ERK1/2 and CREB phosphorylation.?A-582941 enhanced cognitive performance in behavioral models that capture domains of working memory, short-term recognition memory, memory consolidation, and sensory gating deficit.?A-582941 exhibited a benign secondary pharmacodynamic and tolerability profile as assessed in a battery of assays of cardiovascular, gastrointestinal, and CNS function[1]. |
分子量 | 316.83 |
分子式 | C17H21ClN4 |
CAS No. | T8725 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 12 mg/mL (37.88 mM)
You can also refer to dose conversion for different animals. 詳細
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A 582941 HCl (848591-90-2(free base)) T8725 Neuroscience AChR A 582941 HCl (848591902(free base)) A 582941 HCl (848591 90 2(free base)) Inhibitor inhibitor inhibit