Powder: -20°C for 3 years | In solvent: -80°C for 1 year
L-Hyoscyamine (Daturine) functions as a non-selective, competitive antagonist of muscarinic receptors, thereby inhibiting the parasympathetic activities of acetylcholine on the salivary, bronchial, and sweat glands, as well as the eye, heart, bladder, and gastrointestinal tract. Hyoscyamine is a belladonna alkaloid derivative and the levorotatory form of racemic atropine isolated from the plants Hyoscyamus niger or Atropa belladonna, which exhibits anticholinergic activity. These inhibitory effects cause a decrease in saliva, bronchial mucus, gastric juices, and sweat. Furthermore, its inhibitory action on smooth muscle prevents bladder contraction and decreases gastrointestinal motility.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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50 mg | 在庫あり | ¥ 8,500 | |||
100 mg | 在庫あり | ¥ 11,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 11,500 |
説明 | L-Hyoscyamine (Daturine) functions as a non-selective, competitive antagonist of muscarinic receptors, thereby inhibiting the parasympathetic activities of acetylcholine on the salivary, bronchial, and sweat glands, as well as the eye, heart, bladder, and gastrointestinal tract. Hyoscyamine is a belladonna alkaloid derivative and the levorotatory form of racemic atropine isolated from the plants Hyoscyamus niger or Atropa belladonna, which exhibits anticholinergic activity. These inhibitory effects cause a decrease in saliva, bronchial mucus, gastric juices, and sweat. Furthermore, its inhibitory action on smooth muscle prevents bladder contraction and decreases gastrointestinal motility. |
ターゲット&IC50 | AChR:7.5 nM |
In vitro | In vivo studies with conscious rats demonstrated that L-hyoscyamine (20 mg/kg) extended the cyclic period of migrating myoelectric complexes from 17.6 minutes to 29.0 minutes. |
In vivo | In CHO cells, L-hyoscyamine inhibits excitant-induced cAMP production (EC50: 7.8 nM). In murine cardiac (atrial and ventricular) membranes, S-(-)-hyoscyamine enhances cyclic AMP synthesis stimulated by pilocarpine by 24%. R-(+)-hyoscyamine competes with [3H]NMS for binding to muscarinic acetylcholine receptor subtypes (m1-m5), with pKi values of 8.67, 8.51, 7.46, 8.56, and 8.53, respectively. L-hyoscyamine increases the TPase activity turnover rate from 0.19/min to 2.11/min in steady-state kinetic measurements. |
植物由来 |
別名 | Daturine, Hyoscyamine |
分子量 | 289.37 |
分子式 | C17H23NO3 |
CAS No. | 101-31-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 54 mg/mL (186.6 mM)
Ethanol: 54 mg/mL (186.6 mM)
You can also refer to dose conversion for different animals. 詳細
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L-Hyoscyamine 101-31-5 Neuroscience AChR mAChR Daturine Atropine Inhibitor Muscarinic acetylcholine receptor inhibit alkaloid muscarinic Hyoscyamine tropane L Hyoscyamine LHyoscyamine inhibitor