Powder: -20°C for 3 years | In solvent: -80°C for 1 year
A-484954 (A 484954) is a highly specific eukaryotic elongation factor-2 (eEF2, IC50: 280 nM) inhibitor.
説明 | A-484954 (A 484954) is a highly specific eukaryotic elongation factor-2 (eEF2, IC50: 280 nM) inhibitor. |
ターゲット&IC50 | eEF2:280 nM |
In vitro | A-484954 is a selective eEF2K inhibitor and little activity against a wide panel of serine/threonine and tyrosine kinases. In the enzymatic assay, the IC50 value of A-484954 is increased as the concentration of ATP increased but unaffected by increasing concentrations of calmodulin [1]. |
In vivo | Long-term A-484954 treatment inhibits MCT-induced increases PA pressure. Furthermore, A-484954 inhibits MCT-induced NADPH oxidase-1 expression and ROS generation as well as matrix metalloproteinase-2 activation [2]. A484954 causes relaxation in E (+) and E (-) aorta or mesenteric artery precontracted with NA. Pretreatment with L-NAME but not indomethacin or cimetidine partially inhibits the A484954-induced relaxation in mesenteric artery [3]. |
別名 | A 484954 |
分子量 | 289.29 |
分子式 | C13H15N5O3 |
CAS No. | 142557-61-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: Insoluble
DMSO: 20 mg/mL (69.13 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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A-484954 142557-61-7 Autophagy Microbiology/Virology Neuroscience CaMK Parasite Inhibitor Calmodulin-dependent protein kinases A 484954 A484954 inhibit Calmodulin-dependent kinases inhibitor