Powder: -20°C for 3 years | In solvent: -80°C for 1 year
A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. A-3 hydrochloride also inhibits PKC and casein kinase I with Ki values of 47 μM and 80 μM, respectively[1]. A-3 hydrochloride against PKA (Ki=4.3 μM), casein kinase II (Ki=5.1 μM) and myosin light chain kinase (MLCK) (Ki=7.4 μM).
説明 | A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. A-3 hydrochloride also inhibits PKC and casein kinase I with Ki values of 47 μM and 80 μM, respectively[1]. A-3 hydrochloride against PKA (Ki=4.3 μM), casein kinase II (Ki=5.1 μM) and myosin light chain kinase (MLCK) (Ki=7.4 μM). |
ターゲット&IC50 | CK2:5.1 μM (ki), CK1:80 μM (ki), PKC:47 μM (ki), PKA:4.3 μM (ki) |
In vitro | A-3 hydrochloride inhibits MLC-kinase competitively with respect to ATP and that the Ki value is 7.4 μM, and it is also a competitive inhibitor of cAMP-dependent protein kinase, cGMP-dependent protein kinase, protein kinase C, casein kinase I, and casein kinase II, with respect to ATP, exhibits Ki values of 4.3 μM, 3.8 μM, 47 μM, 80 μM, and 5.1 μM, respectively[1]. |
分子量 | 321.22 |
分子式 | C12H14Cl2N2O2S |
CAS No. | 78957-85-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (389.14 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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A-3 hydrochloride 78957-85-4 Chromatin/Epigenetic Cytoskeletal Signaling Metabolism Neuroscience Stem Cells Tyrosine Kinase/Adaptors CaMK Casein Kinase PKA PKC Calmodulin-dependent kinases inhibit inhibitor A 3 hydrochloride cAMP calmodulin A3 Hydrochloride kinase A-3 MLC-kinase Calmodulin-dependent protein kinases Protein kinase C Protein kinase A A 3 Hydrochloride A 3 A-3 Hydrochloride casein A3 hydrochloride Inhibitor