Powder: -20°C for 3 years | In solvent: -80°C for 1 year
A-867744 is an effective and selective type II positive allosteric modulator of the α7 nAChR (EC50: 1.0 μM).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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2 mg | 在庫あり | ¥ 9,000 | |||
5 mg | 在庫あり | ¥ 15,000 | |||
10 mg | 在庫あり | ¥ 22,500 | |||
25 mg | 在庫あり | ¥ 44,500 | |||
50 mg | 在庫あり | ¥ 80,000 | |||
100 mg | 在庫あり | ¥ 119,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 21,500 |
説明 | A-867744 is an effective and selective type II positive allosteric modulator of the α7 nAChR (EC50: 1.0 μM). |
ターゲット&IC50 | α7 nAChR:1.0 μM (EC50) |
In vitro | A-867744(Compound 19), a novel type II PAM with good potency and selectivity.?Compound 19 showed acceptable pharmacokinetic profile across species and brain levels sufficient to modulate alpha7 nAChRs.?In a rodent model of sensory gating, 19 normalized gating deficits.?These results suggest that 19 represents a novel class of molecules capable of allosteric modulation of the alpha7 nAChRs[2]. |
分子量 | 402.89 |
分子式 | C20H19ClN2O3S |
CAS No. | 1000279-69-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (248.21 mM)
You can also refer to dose conversion for different animals. 詳細
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A-867744 1000279-69-5 Autophagy Neuroscience AChR Inhibitor inhibit nAChR A 867744 Nicotinic acetylcholine receptors A867744 inhibitor