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T12165 |
nAChR agonist 1
|
DUN71755 |
AChR
|
|
nAChR agonist 1 (DUN71755) is a brain-permeable and orally efficacious positive allosteric α7 nicotinic acetylcholine receptor (α7 nAChR)modulator. |
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T39771 |
nAChR agonist CMPI hydrochloride
|
|
|
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CMPI hydrochloride, a potent and selective nAChR agonist, functions as a positive allosteric modulator (PAM) specifically targeting the α4:α4 subunit interface of the nAChR. It enhances the response of the (α4)3(β2)2 nAC... |
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T40177 |
nAChR agonist 2
|
|
|
|
Compound 8, identified as a selective alpha4beta2 (α4β2) neuronal acetylcholine receptor (nAChR) agonist, demonstrates a dissociation constant (Kd) of 26 nM, indicating high affinity for this receptor subtype. |
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T74396 |
nAChR modulator-1
|
|
|
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nAChR modulator-1, a insecticide, is a insect nAChR orthosteric modulator [1] . |
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T74397 |
nAChR modulator-2
|
|
|
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nAChR modulator-2, a insecticide, is a insect nAChR orthosteric modulator [1] . |
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T61064 |
nAChR antagonist 1
|
|
|
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nAChR antagonist 1 (compound B15) is a highly effective antagonist of α7 nAChR, demonstrating an IC50 value of 3.3 μM. Its versatility makes it an ideal candidate for investigating the pathogenesis of schizophrenia, Alzh... |
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T62317 |
α7 nAchR-JAK2-STAT3 agonist 1
|
|
|
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α7 nAchR-JAK2-STAT3 agonist 1 is a potent inhibitor of the α7 nAchR-JAK2-STAT3 pathway that acts on nitric oxide (NO) (IC50: 0.32 μM). α7 nAchR-JAK2-STAT3 agonist 1 has been shown to have a positive effect on iNOS, IL-1β... |
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T8868 |
4BP-TQS
|
|
AChR
|
|
4BP-TQS is an allosteric agonist of α7 nAChRs. |
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T9542 |
NS3861
|
|
AChR
|
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NS3861 is an agonist of nicotinic acetylcholine receptors (nAChRs) and bind with high affinity to heteromeric α3β4 and α4β2 nAChRs. NS3861 displays the β-subunit preference and a complete lack of activation at α4-contain... |
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T17300 |
(-)-(S)-B-973B
|
|
AChR
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(-)-(S)-B-973B is an effective allosteric agonist and a positive allosteric modulator of α7 nAChR. |
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T14094 |
Acetamiprid
|
|
AChR
|
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Acetamiprid is a nicotinic acetylcholine receptor (nAChR) agonist. Acetamiprid is a neonicotinoid insecticide used worldwide. It is shown to be associated with neuromuscular and reproductive disorders. |
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T1594 |
Vecuronium bromide
|
ORG NC 45 |
AChR
|
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Vecuronium bromide (ORG NC 45) is a synthetic, intermediate-acting mono-quaternary steroid and non-depolarizing neuromuscular blocking agent, with muscle relaxant activity. |
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T2422 |
PNU-282987
|
|
AChR
|
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PNU-282987 is a selective α7 nicotinic acetylcholine receptor(α7 nAChR) agonist with Ki of 26 nM; no affinity for α1β1γδ and α3β4 nAChRs (IC50 ≥ 60 μM). |
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TQ0117 |
A-867744
|
|
AChR
,
Autophagy
|
|
A-867744 is an effective and selective type II positive allosteric modulator of the α7 nAChR (EC50: 1.0 μM). |
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T37196 |
5-AAM-2-CP
|
|
AChR
|
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5-AAM-2-CP is one of the major metabolites of Acetamiprid. Acetamiprid, a nAChR agonist, is a neonicotinoid insecticide used worldwide. |
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T9787 |
Suvn-911
|
|
AChR
|
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suvn-911 is a potent and selective antagonist of neuronal nicotinic acetylcholine α4β2 receptor (Ki = 1.5 nM) with antidepressant activity. |
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T7193 |
Encenicline
|
EVP-6124 |
AChR
|
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Encenicline (EVP-6124) is a selective α7 nicotinic acetylcholine receptor (nAChRs) agonist in development for treating cognitive impairment in schizophrenia and Alzheimer's disease. |
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T28199 |
NS9283
|
NS 9283,NS-9283 |
AChR
|
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NS9283 is a positive allosteric modulator of α4β2 receptor. |
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T27624 |
Iptakalim Hydrochloride
|
|
Potassium Channel
,
AChR
|
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Iptakalim, a lipophilic para-amino compound, is a novel ATP-sensitive potassium channel (KATP) opener, as well as an α4β2-containing nicotinic acetylcholine receptor (nAChR) antagonist. Iptakalim is also a K(ir) 6.1/SUR2... |
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T8552 |
PSEM 89S TFA
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AChR
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PSEM 89S TFA is a brain-penetrant and selective ion channels agonist, and is orthogonally selective for Q79G and L141F, respectively. |
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TP2063 |
α-Conotoxin MII
|
|
AChR
|
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α-Conotoxin MII is a highly potent and selective competitive antagonist for α3β2 subunit-containing nicotinic receptors (IC50 = 0.5 - 3.5 nM at α3β2 expressed in Xenopus oocytes). Also potently blocks β3-containing neuro... |
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T4246 |
Varenicline dihydrochloride
|
|
AChR
|
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Varenicline dihydrochloride is a Selective α4β2 nicotinic acetylcholine receptor partial agonist. |
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T7124 |
Dinotefuran
|
MTI-446 |
Others
,
AChR
,
Parasite
|
|
Dinotefuran (MTI-446) is an insecticide of the neonicotinoid class for control of insect pests such as aphids, whiteflies, thrips, leafhoppers, leafminers. Its mechanism of action involves disruption of the insect's nerv... |
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T12653 |
(Rac)-ABT-202 dihydrochloride
|
|
AChR
|
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(Rac)-ABT-202 dihydrochloride is a racemate of ABT-202. ABT-202 is an nicotinic acetylcholine receptors (nAChRs) agonist and can be used as an analgesic. |
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T0401 |
Benzethonium chloride
|
Hyamine,Phemeride,Quatrachlor |
AChR
|
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Benzethonium chloride (Quatrachlor) is a synthetic quaternary ammonium salt with surfactant, antiseptic, and broad spectrum antimicrobial properties. |
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T7422 |
CCMI
|
AVL-3288 |
AChR
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CCMI (AVL-3288) is a potent and selective modulator of α7 nAChR-positive allosteric. |
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T23348 |
SEN12333
|
SEN 12333 |
AChR
|
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SEN12333 is an α7 nicotinic acetylcholine receptor (nAChR) agonist |
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T6607 |
Nitenpyram
|
Niterndipoine,Bestguard,Capstar |
AChR
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Nitenpyram (Capstar) is a nicotinic acetylcholine receptor (AchR) agonist, used as veterinary medicine to treat parasites of livestock and pets. |
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T1459 |
Cisatracurium besylate
|
51W89 |
Adrenergic Receptor
,
AChR
,
Autophagy
|
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Cisatracurium besylate (51W89) is a nondepolarizing skeletal muscle relaxant for intravenous administration. |
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T0818 |
Decamethonium bromide
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Decacuran,Syncurine |
AChR
,
AChE
|
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Decamethonium bromide (Syncurine) is a neuromuscular blocker and nicotinic AChR partial agonist. |
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T7695 |
PNU-282987 S enantiomer free base
|
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AChR
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PNU-282987 S enantiomer free base is an agonist of α7 nicotinic acetylcholine receptor (α7 nAChR). |
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T7884 |
NS 1738
|
NSC 213859 |
AChR
|
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NS 1738 (NSC-213859) is a positive allosteric modulator of the α7-containing neuronal nicotinic acetylcholine receptors (nAChRs) |
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T0395 |
Pyrantel tartrate
|
Banminth |
Antibiotic
,
Parasite
|
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Pyrantel tartrate (Banminth) is broad spectrum anthelmintic for livestock. |
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T0166 |
Pancuronium dibromide
|
Pancuronium bromide,Pavulon |
AChR
|
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Pancuronium dibromide (Pavulon), a competitive AChR antagonist (IC50 = 5.5 nM), acts as a skeletal muscle relaxant. Pancuronium dibromide(Pancuronium bromide) blocking neuromuscular transmission is achieved by competing ... |
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T1259 |
Pyrantel pamoate
|
Pyrantel embonate |
Others
,
Antibiotic
,
Parasite
|
|
Pyrantel pamoate (Pyrantel embonate) is a depolarizing neuromuscular blocking agent. |
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T22448 |
Tropisetron
|
Tropisetronum,Tropisteron,ICS 205-930 |
5-HT Receptor
,
AChR
|
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Tropisetron (ICS 205-930) is an α7-nicotinic receptor agonist and 5-HT3 receptor antagonist with Kis of 6.9 nM and 5.3 nM, respectively. |
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T28531 |
Facinicline hydrochloride
|
RG3487 |
5-HT Receptor
,
AChR
|
|
Facinicline hydrochloride (RG3487) is both a novel nicotinic alpha-7 receptor (alpha7nAChR) partial agonist (Ki = 6 nM) and an antagonist of 5-HT3(Ki = 1.2 nM). Facinicline hydrochloride improves cognition and sensorimot... |
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T0072 |
Adiphenine hydrochloride
|
Adiphenine HCl,Spasnil,Patrovina,Sentiv |
AChR
|
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Adiphenine hydrochloride (Patrovina), a nicotinic receptor inhibitor, can be used as an antispasmodic drug. |
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T60080 |
TMPH
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2,2,6,6-Tetramethylpiperidin-4-yl heptanoate |
AChR
|
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TMPH is an inhibitor of nAChR and inhibits nAChRs lacking α5, α6, or β3 subunits. TMPH can be used in studies about nAChR dysfunction or neurological disorders. |
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T0333 |
Aniracetam
|
Ro 13-5057 |
Dopamine Receptor
,
5-HT Receptor
,
GluR
,
AChR
,
iGluR
|
|
Aniracetam (Ro 13-5057)(Ro 13-5057), a nootropic and neuroprotective drug, selectively modulates the AMPA receptor and nAChR. |
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T0287 |
Hexamethonium Bromide
|
Gangliostat,Simpatoblock,Hexamethonium Dibromide |
Apoptosis
,
Dopamine Receptor
,
AChR
|
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Hexamethonium Bromide (Hexamethonium Dibromide), a specific antagonist of neuronal-type nicotinic AChR in ganglia, is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. |
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T8448 |
ZSET1446
|
ZSET-1446,ST-101 |
Calcium Channel
,
AChR
|
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ZSET1446 (ST-101) is a T-type calcium channel activator potentially for the treatment of learning deficits in various types of Alzheimer disease (AD) models. |
|
T6397 |
Atracurium besylate
|
Tracrium,51W89,BW-33A |
AChR
|
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Atracurium besylate (51W89) is a non-depolarizing neuromuscular blocking agent with short duration of action. Its lack of significant cardiovascular effects and its lack of dependence on good kidney function for eliminat... |
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T22371 |
Mivacurium dichloride
|
Mivacurium chloride |
AChR
|
|
Mivacurium dichloride (Mivacurium chloride) is a non-depolarising, rapid neuromuscular blocker of short duration, used therefore as anesthetic, to provide skeletal muscle relaxation in minor surgical operations, in emerg... |
|
T6950 |
PNU-120596
|
NSC 216666 |
AChR
|
|
PNU-120596 (NSC-216666) is a positive allosteric modulator of α7 nAChR with EC50 of 216 nM. |
|
T8318 |
BNC210
|
H-Ile-Trp-OH,IW-2143 |
AChR
|
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BNC210 (IW-2143) is a α7 nAChR negative allosteric modulator. BNC210 has potent activity in animal models of anxiety and depression. |
|
T23469 |
TQS
|
4-Naphthalen-1-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide |
AChR
|
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TQS (4-Naphthalen-1-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide) is a positive allosteric modulator of α7 nACh receptors. |
|
T2141 |
Mecamylamine hydrochloride
|
Inversine,Mevasin |
AChR
|
|
Mecamylamine hydrochloride (Mevasin) is a nicotinic antagonist, used as a ganglionic blocker in hypertension. |
|
T22016 |
A-582941 dihydrochloride
|
A 582941 |
5-HT Receptor
,
AChR
|
|
A-582941 dihydrochloride (A 582941) is a Selective agonist of α7 nAChR partial |
|
T1401 |
Meclofenoxate hydrochloride
|
Meclofenoxate (Centrophenoxine) HCl,Lucidril,Cerutil,Meclofenoxate HCl |
Lipoxygenase
,
COX
,
AChR
,
iGluR
|
|
Meclofenoxate hydrochloride (Lucidril) is an ester of DIMETHYLAMINOETHANOL and para-chlorophenoxyacetic acid. It has been shown to improve memory and general cognition, and mentally stimulating effect. |
