Powder: -20°C for 3 years | In solvent: -80°C for 1 year
A-935142 is a human ether-a-go-go-related gene (hERG, Kv 11.1) channel activator. a-935142 enhances hERG currents by slowing inactivation, promoting activation, reducing inactivation, shortening atrial and ventricular repolarization, and in a complex manner.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 80,500 |
5 mg | 在庫あり | ¥ 190,000 |
10 mg | 在庫あり | ¥ 259,500 |
25 mg | 在庫あり | ¥ 365,000 |
50 mg | 在庫あり | ¥ 454,500 |
100 mg | 在庫あり | ¥ 574,000 |
500 mg | 在庫あり | ¥ 1,124,500 |
説明 | A-935142 is a human ether-a-go-go-related gene (hERG, Kv 11.1) channel activator. a-935142 enhances hERG currents by slowing inactivation, promoting activation, reducing inactivation, shortening atrial and ventricular repolarization, and in a complex manner. |
In vitro |
A-935142 (60μM) increases both outward and inward K(+) current as well as the slope conductance of the linear portion of the fully activated I-V relation. A-935142 shortens cardiac action potentials and enhances the amplitude of the hERG current in a concentration- and voltage-dependent manner. A-935142 significantly reduces the time constants (tau) of hERG channel activation at two example voltages and shifts the voltage dependence for hERG activation in the hyperpolarizing direction by 9 mV.[2] A-935142 shortens the action potential duration (APD90) in guinea pig atrial tissue and canine cardiac Purkinje fibers[1]. |
分子量 | 352.35 |
分子式 | C18H19F3N2O2 |
CAS No. | 1031335-85-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 5.63 mg/mL (15.96 mM)
You can also refer to dose conversion for different animals. 詳細
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A-935142 1031335-85-9 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR A935142 A 935142 Inhibitor inhibitor inhibit