Powder: -20°C for 3 years | In solvent: -80°C for 1 year
JND3229 is a reversible EGFRC797S inhibitor with IC50 values of 5.8, 6.8 and 30.5 nM for EGFRL858R/T790M/C797S, EGFRWT and EGFRL858R/T790M, respectively. JND3229 has good anti-proliferative activity and can effectively inhibit tumour growth in vivo. JND3229 can be used in cancer research, especially in non-small cell carcinoma.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 29,500 | |||
5 mg | 在庫あり | ¥ 75,000 | |||
10 mg | 在庫あり | ¥ 112,500 | |||
25 mg | 在庫あり | ¥ 186,500 | |||
50 mg | 在庫あり | ¥ 259,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 102,000 |
説明 | JND3229 is a reversible EGFRC797S inhibitor with IC50 values of 5.8, 6.8 and 30.5 nM for EGFRL858R/T790M/C797S, EGFRWT and EGFRL858R/T790M, respectively. JND3229 has good anti-proliferative activity and can effectively inhibit tumour growth in vivo. JND3229 can be used in cancer research, especially in non-small cell carcinoma. |
In vitro | JND3229 potently inhibits the proliferation of BaF3 cells (harboring the EGFRL858R/T790M/C797S and EGFR19D/T790M/C797Smutations), NCI-H1975 NSCLC cells (with EGFRT790M mutation) and A431 cancer cells (overexpressing EGFRWT) with IC50 values of 0.51, 0.32, 0.31 and 0.27 µM, respectively. JND3229 (0.1, 0.3, 1, 3, 10 µM; 2 h) potently inhibits the phosphorylation of EGFRL858R/T790M/C797S and EGFR19D/T790M/C797S in engineering BaF3 cells[1]. |
In vivo | JND3229 (10 mg/kg; i.p.; twice daily for 10 days) exhibits an obvious suppression of tumor growth, and shows target inhibition in vivo[1]. |
分子量 | 617.18 |
分子式 | C33H41ClN8O2 |
CAS No. | 2260886-64-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 11.7 mg/mL (19 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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JND3229 2260886-64-2 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR JND-3229 JND 3229 Inhibitor inhibitor inhibit