Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AM-2394 is an effective and specific Glucokinase agonist (GKA, EC50: 60 nM), which catalyzes the phosphorylation of glucose to glucose-6-phosphate. AM-2394(AM2394) increases the affinity of GK for glucose by approximately 10-fold, exhibits moderate clearance and good oral bioavailability in multiple animal models, and lowers glucose excursion following an oral glucose tolerance test in an ob/ob mouse model of diabetes.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 7,500 | |||
5 mg | 在庫あり | ¥ 16,500 | |||
10 mg | 在庫あり | ¥ 26,000 | |||
25 mg | 在庫あり | ¥ 52,500 | |||
50 mg | 在庫あり | ¥ 80,000 | |||
100 mg | 在庫あり | ¥ 123,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 18,500 |
説明 | AM-2394 is an effective and specific Glucokinase agonist (GKA, EC50: 60 nM), which catalyzes the phosphorylation of glucose to glucose-6-phosphate. AM-2394(AM2394) increases the affinity of GK for glucose by approximately 10-fold, exhibits moderate clearance and good oral bioavailability in multiple animal models, and lowers glucose excursion following an oral glucose tolerance test in an ob/ob mouse model of diabetes. |
ターゲット&IC50 | GKA:60 nM(EC50) |
In vivo | AM-2394, a novel glucokinase activator, prominently reduces plasma glucose levels in ob/ob mice during an oral glucose tolerance test (OGTT) at a 3 mg/kg dosage. It enhances glucokinase's (GK) glucose affinity by roughly 10-fold, showing moderate clearance and favorable oral bioavailability across various animal models. Additionally, AM-2394 significantly improves glucose control following an OGTT in an ob/ob mouse model of diabetes. It demonstrates suitable cross-species plasma clearance, distribution volume, and oral bioavailability, supporting its potential for further investigation in animal studies[1]. |
キナーゼ試験 | Kinase screen: Briefly, all assays (25.5 μl at 21°C for 30 min) are performed using a Biomek 2000 Laboratory Automation Workstation in a 96-well format. Reactions contains 5–20 mU purified kinase along with substrate peptide or protein and are initiated by the addition of 10 mM MgAcetate and 5, 20, or 50 μM ATP ([γ-33P]-ATP, 800 cpm/pmol). |
別名 | AM2394 |
分子量 | 423.46 |
分子式 | C22H25N5O4 |
CAS No. | 1442684-77-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (118.15 mM)
You can also refer to dose conversion for different animals. 詳細
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AM-2394 1442684-77-6 Metabolism Glucokinase Hexokinase D Inhibitor AM 2394 AM2394 inhibit Hexokinase IV inhibitor