Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AP1189 acetate is a biased agonist at melanocortin 1 and melanocortin 3 receptors.
説明 | AP1189 acetate is a biased agonist at melanocortin 1 and melanocortin 3 receptors. |
In vitro | Added to macrophage cultures, AP1189 reduced cytokine release, an effect reliant on both MC1 and MC3 as evident from the use of Mc1r(-/-) and Mc3r(-/-) macrophages. No melanogenesis was induced by AP1189 in B16-F10 melanocytes[1]. |
In vivo | Oral AP1189 elicited anti-inflammatory actions in peritonitis and, upon administration at the peak of inflammation, accelerated the resolution phase by ~3-fold[1]. |
分子量 | 358.35 |
分子式 | C16H18N6O4 |
CAS No. | 959850-74-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (139.53 mM)
You can also refer to dose conversion for different animals. 詳細
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AP1189 acetate 959850-74-9 GPCR/G Protein Neuroscience Melanocortin Receptor AP-1189 acetate AP1189 Acetate AP-1189 Acetate AP 1189 Acetate Inhibitor inhibitor inhibit