Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AR-M 1896 Acetate is the selective agonist of GalR2.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 216,000 |
5 mg | 在庫あり | ¥ 431,500 |
10 mg | 在庫あり | ¥ 587,500 |
25 mg | 在庫あり | ¥ 867,500 |
50 mg | 在庫あり | ¥ 1,177,500 |
100 mg | 在庫あり | ¥ 1,588,500 |
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 897,500 |
説明 | AR-M 1896 Acetate is the selective agonist of GalR2. |
ターゲット&IC50 | GalR2:1.76 nM, GalR1 (human):879 Nm |
In vitro | Removal of the glycine residue in position 1 resulted in AR-M1896 with almost unchanged GalR2 affinity and functional activity, and 500-fold selectivity for GalR2-Rs over GalR1-Rs[1].? |
In vivo | In normal rats mechanical and cold allodynia of the hindpaw are induced by intrathecal infusion of low-dose galanin. The same effect is seen with equimolar doses of AR-M1896 or AR-M961 (an agonist both at GalR1 and GalR2 receptors). In allodynic Bennett model rats, the mechanical threshold dose-dependently increased after intrathecal injection of a high AR-M961dose, whereas no effect was observed in the control or AR-M1896 group. No effect of either compounds was observed in nonallodynic Bennett model rats[1]. |
別名 | AR-M 1896 Acetate (367518-31-8 Free base) |
分子量 | 1196.35 |
分子式 | C56H85N13O16 |
CAS No. | T21646L |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/ml (45.97 mM)
You can also refer to dose conversion for different animals. 詳細
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AR-M 1896 Acetate T21646L GPCR/G Protein Neuroscience Neuropeptide Y Receptor 367518-31-8 Free base ARM 1896 Acetate AR M 1896 Acetate AR-M-1896 Acetate 367518-31-8 AR-M 1896 Acetate (367518-31-8 Free base) AR-M1896 Acetate Inhibitor inhibitor inhibit