store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AZ-23 is an inhibitor of ATP-competitive and Trk kinase A/B/C. For TrkA, TrkB, FGFR1, Flt3, Ret, MuSk, Lck, the IC50s values are 2 nM, 8 nM, 24 nM, 52 nM, 55 nM, 84 nM, 99 nM, respectively.
ターゲット&IC50 | TrkA:2 nM, TrkB:8 nM |
In vivo | Following oral administration in a TrkA-driven allograft model, AZ-23 demonstrates effective in vivo inhibition of TrkA kinase and efficacy in mice. It also significantly inhibits tumor growth in a Trk-expressing xenograft model of neuroblastoma[1]. |
別名 | AZ 23, AZ23 |
分子量 | 391.83 |
分子式 | C17H19ClFN7O |
CAS No. | 915720-21-7 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (319.02 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
AZ-23 915720-21-7 Tyrosine Kinase/Adaptors Trk receptor AZ 23 Tropomyosin related kinase receptor Inhibitor AZ23 inhibit Trk Receptor inhibitor