Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AZ7550 hydrochloride (AZ7550 hydrochloride ), an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 29,000 | |||
5 mg | 在庫あり | ¥ 59,000 | |||
10 mg | 在庫あり | ¥ 91,500 | |||
25 mg | 在庫あり | ¥ 152,500 | |||
50 mg | 在庫あり | ¥ 217,000 |
説明 | AZ7550 hydrochloride (AZ7550 hydrochloride ), an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM). |
ターゲット&IC50 | FLT3:302 nM , FAK:995 nM , FES:449 nM , PYK2:2288 nM , Ack1:156 nM , INSR:1256 nM , BLK:977 nM , ALK:420 nM , Brk:843 nM , MNK2:228 nM , MLK1:88 nM , FLT4:1784 nM , IGF-1R:1.6 μM , ERB4:195 nM , TEC:1317 nM , IRR:840 nM |
In vitro | AZ7550 (Compound 28) inhibits double mutant (DM) cell line H1975, activating mutant (AM) cell line PC9, and wild type (WT) cell line LoVo (IC50s: 45, 26, and 786 nM). AZ7550 inhibits DM antiproliferative cell line H1975, AM antiproliferative cell line PC9, and WT antiproliferative cell line Calu3 (GI50s: 19, 15, and 537 nM). |
別名 | AZ7550 hydrochloride (1421373-99-0 free base) |
分子量 | 522.04 |
分子式 | C27H32ClN7O2 |
CAS No. | 2309762-40-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 1.5 mg/mL (2.8 mM), Sonication and heating are recommended.
You can also refer to dose conversion for different animals. 詳細
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AZ7550 hydrochloride 2309762-40-9 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR IGF-1R ErbB-1 Epidermal growth factor receptor HER1 Drug Metabolite AZ-7550 Hydrochloride AZ7550 Hydrochloride inhibit AZ7550 1421373-99-0 AZ-7550 1421373-99-0 free base AZ 7550 Hydrochloride AZ 7550 AZ7550 hydrochloride (1421373-99-0 free base) Inhibitor AZ-7550 hydrochloride inhibitor