Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NSC 228155 is an activator of EGFR, binding to the sEGFR dimerization domain II and modulate EGFR tyrosine phosphorylation.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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5 mg | 在庫あり | ¥ 10,000 | |||
10 mg | 在庫あり | ¥ 14,000 | |||
25 mg | 在庫あり | ¥ 29,500 | |||
50 mg | 在庫あり | ¥ 53,000 | |||
100 mg | 在庫あり | ¥ 92,000 | |||
200 mg | 在庫あり | ¥ 119,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 11,000 |
説明 | NSC 228155 is an activator of EGFR, binding to the sEGFR dimerization domain II and modulate EGFR tyrosine phosphorylation. |
ターゲット&IC50 | KIX-KID:0.36 μM |
In vitro | NSC 228155 promotes transactivation of several RTKs, including ErbB2 and ErbB3, Insulin R and IGF-1 R receptors in the cells. It stimulates dimerization of sEGFR domain II[1]. NSC 228155 can rapidly move across cell membranes and disperse within both cytoplasmic and nuclear compartments. It rapidly generates hydrogen peroxide within cells[2]. NSC 228155 is also a potent inhibitor of KIX-KID interaction(IC50 = 0.36 μM), but it is not particularly selective against CREB-mediated gene transcription in HEK 293T cells[3]. |
細胞研究 | MDA MB468 cells serum-starved overnight are pre-incubated (or not) with 10?μM AG1478 or 2?μM PD 153035 for 90?min and then, where indicated, incubated with 100?μM NSC 228155 or CN 009543V or 150?ng/ml EGF or vehicle (0.2% DMSO) for 15?min. Proteins are blotted to nitrocellulose membrane and analyzed with biotinylated anti-pTyr P100, anti-pEGFR Y1068 and anti-EGFR (epitope in cytoplasmic region) antibodies. (Only for Reference) |
別名 | NSC228155 |
分子量 | 290.25 |
分子式 | C11H6N4O4S |
CAS No. | 113104-25-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 12 mg/mL (41.3 mM)
You can also refer to dose conversion for different animals. 詳細
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NSC 228155 113104-25-9 Angiogenesis Cell Cycle/Checkpoint Chromatin/Epigenetic DNA Damage/DNA Repair JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR Epigenetic Reader Domain Histone Acetyltransferase DNA/RNA Synthesis Epidermal growth factor receptor NSC-228155 HER1 HATs inhibit NSC228155 Inhibitor HAT ErbB-1 inhibitor