Powder: -20°C for 3 years | In solvent: -80°C for 1 year
S1R agonist 2 is a selective S1R agonist with a Ki of 88 nM for S2R and 1.1 nM for S1R and is protective against ROS and NMDA-induced neurotoxicity.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 9,000 | |||
5 mg | 在庫あり | ¥ 21,500 | |||
10 mg | 在庫あり | ¥ 34,000 | |||
25 mg | 在庫あり | ¥ 66,000 | |||
50 mg | 在庫あり | ¥ 100,000 | |||
100 mg | 在庫あり | ¥ 147,500 | |||
500 mg | 在庫あり | ¥ 312,500 |
説明 | S1R agonist 2 is a selective S1R agonist with a Ki of 88 nM for S2R and 1.1 nM for S1R and is protective against ROS and NMDA-induced neurotoxicity. |
ターゲット&IC50 | σ1 receptor:1.1 nM (Ki), σ2 receptor:88 nM (Ki) |
In vitro |
S1R agonist 2 (Compound 8b; 0.1-5 μ M) Both can significantly increase the growth of Neurite induced by nerve growth factor (NGF) in a dose-dependent manner.[1] The concentration of S1R agonist 2 (24 hours) in SHSY5Y cells is 1 μ M has a significant inhibitory effect on cell damage induced by Rotenone.[1] S1R agonist 2 (0.1-5 μ M; 24 hours) Neuroprotective effect on NMDA stimulation in SHSY5Y cells.[1] S1R agonist 2 (0-10 μ M; 24-72 hours) has no cytotoxicity to A549, LoVo, and Panc-1 cells.[1] |
分子量 | 309.45 |
分子式 | C21H27NO |
CAS No. | 150085-21-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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S1R agonist 2 150085-21-5 GPCR/G Protein Immunology/Inflammation Neuroscience Sigma receptor ROS NMDAR Inhibitor inhibitor inhibit