Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BC-1258 is a unique small molecule F-box/LRR-repeat protein 2 (FBXL2) activator.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
5 mg | 在庫あり | ¥ 11,000 | |||
10 mg | 在庫あり | ¥ 17,500 | |||
25 mg | 在庫あり | ¥ 37,500 | |||
50 mg | 在庫あり | ¥ 60,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 14,000 |
説明 | BC-1258 is a unique small molecule F-box/LRR-repeat protein 2 (FBXL2) activator. |
In vitro | BC-1258, stabilized and increased levels of FBXL2 protein that promoted Aurora B degradation, resulting in tetraploidy, mitotic arrest and apoptosis of tumorigenic cells, and profoundly inhibiting tumor formation in athymic nude mice.?These findings uncover a new proteolytic mechanism targeting a key regulator of cell replication that may serve as a basis for chemotherapeutic intervention in neoplasia. |
別名 | BC-1258 |
分子量 | 406.57 |
分子式 | C22H22N4S2 |
CAS No. | 1507370-40-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 4.07 mg/mL (10 mM)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
BC-1258 1507370-40-2 Apoptosis LRR F-box BC1258 inhibit repeat BC-1258 BC-?1258 BC 1258 FBXL2 tumor Inhibitor BC1258 BC 1258 inhibitor