Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Piclidenoson (CF-101), a selective agonist of adenosine A3 receptor(EC50 values of 0.11 μM), induces robust anti-inflammatory effect in psoriasis patients.
説明 | Piclidenoson (CF-101), a selective agonist of adenosine A3 receptor(EC50 values of 0.11 μM), induces robust anti-inflammatory effect in psoriasis patients. |
In vitro | Piclidenoson inhibited the proliferation of HaCat cells through deregulation of the NF-κB signaling pathway, leading to a decrease in interleukin-17 and interleukin-23 expression levels[1]. |
細胞研究 | [3H]-Thymidine incorporation assay was used to evaluate cell growth.?HaCat cells (2500 cells/well) were incubated with piclidenoson 10?nM and MRS 1523 (50?nM) in 96-well plate for 48 hours.?For the last 24 hours of incubation, each well was pulsed with 1?mCi [3H]-thymidine.?Cells were harvested, and the [3H]-thymidine uptake was determined in an LKB liquid scintillation counter (LKB, Piscataway, NJ, USA).?These experiments were repeated at least 4 times[1]. |
別名 | CF-101, IB-MECA |
分子量 | 510.29 |
分子式 | C18H19IN6O4 |
CAS No. | 152918-18-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (88.19 mM)
You can also refer to dose conversion for different animals. 詳細
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Piclidenoson 152918-18-8 Apoptosis GPCR/G Protein Neuroscience Adenosine Receptor diseases P1 receptor CF-101 inhibit Inhibitor leukemia CF 101 CF101 prostate melanoma antiproliferative colon inflammatory breast autoimmune IB-MECA COVID-19 inhibitor