Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BI-78D3, a competitive JNK inhibitor. IC50 of BI-78D3 is 280 nM that displays > 100 fold selectivity over p38α, and have no activity at mTOR and PI-3K.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 7,000 | |||
5 mg | 在庫あり | ¥ 14,500 | |||
10 mg | 在庫あり | ¥ 24,500 | |||
25 mg | 在庫あり | ¥ 54,000 | |||
50 mg | 在庫あり | ¥ 89,000 | |||
100 mg | 在庫あり | ¥ 124,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 14,500 |
説明 | BI-78D3, a competitive JNK inhibitor. IC50 of BI-78D3 is 280 nM that displays > 100 fold selectivity over p38α, and have no activity at mTOR and PI-3K. |
ターゲット&IC50 | JNK:280 nM |
In vitro | BI-78D3 Inhibits JNK interacting protein 1 (JIP1)-JNK binding and prevents JNK substrate phosphorylation[2]. |
In vivo | In animal studies, BI-78D3 not only blocks JNK dependent Con A-induced liver damage but also restores insulin sensitivity in mouse models of type 2 diabetes[1]. |
細胞研究 | Cells are subjected to a dose range of doxorubicin concentrations in the presence or absence of a non-toxic dose (10 nM) of the small molecule JIP1-inhibitor BI-78D3. (Only for Reference) |
分子量 | 379.37 |
分子式 | C13H9N5O5S2 |
CAS No. | 883065-90-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 1.9 mg/mL (5 mM)
DMSO: 37.9 mg/mL (100 mM)
You can also refer to dose conversion for different animals. 詳細
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BI-78D3 883065-90-5 MAPK JNK BI-78D-3 inhibit BI 78D3 Inhibitor BI78D3 inhibitor