keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Gartanin is an androgen receptor degradation enhancer, it is also a potential neuroprotective agent against glutamate-induced oxidative injury partially through increasing Nrf-2-independed HO-1 and AMPK/SIRT1/PGC-1α±signaling pathways.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 37,500 | |||
5 mg | 在庫あり | ¥ 90,000 | |||
10 mg | 在庫あり | ¥ 136,500 | |||
25 mg | 在庫あり | ¥ 218,000 | |||
50 mg | 在庫あり | ¥ 296,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 91,500 |
説明 | Gartanin is an androgen receptor degradation enhancer, it is also a potential neuroprotective agent against glutamate-induced oxidative injury partially through increasing Nrf-2-independed HO-1 and AMPK/SIRT1/PGC-1α±signaling pathways. |
In vitro | The interaction of Gartanin with the ligand-binding domain was characterized using a fluorescence polarization cell-free assay and cell-based FRET assay. Western blot analysis identified modulation of ER stress markers (BiP, PERK, IRE1, and CHOP) along with androgen receptor degradation. A computation simulation was performed to identify possible orientations of Gartanin with the ligand-binding domain. Utilizing a cell-free and cell-based FRET assays Gartanin was found to interact with the ligand-binding domain through a solely antagonist interaction. Interestingly, inhibition of CHOP, a critical component of the ER stress pathway, was observed to stabilize AR[1] |
植物由来 |
分子量 | 396.43 |
分子式 | C23H24O6 |
CAS No. | 33390-42-0 |
keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (126.13 mM)
You can also refer to dose conversion for different animals. 詳細
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Gartanin 33390-42-0 Apoptosis MAPK Proteases/Proteasome Caspase JNK BCL Fungal Autophagy inhibit Inhibitor inhibitor