Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BMS-345541 hydrochloride is a selective IKK inhibitor (IKK2 and IKK1 with IC50 of 0.3 μM and 4 μM,respectively).
説明 | BMS-345541 hydrochloride is a selective IKK inhibitor (IKK2 and IKK1 with IC50 of 0.3 μM and 4 μM,respectively). |
ターゲット&IC50 | IKK1:4 μM, IKK2:0.3 μM |
In vitro | BMS-345541 down-regulation of IKK activity results in mitochondria-mediated apoptosis of tumor cells because the programmed cell death machinery in melanoma cells is highly regulated by NF-kappaB signaling. Therefore, IKK may serve as a potential target for melanoma therapy[1]. |
分子量 | 291.78 |
分子式 | C14H18ClN5 |
CAS No. | 547757-23-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 18 mg/mL (61.69 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
BMS-345541 hydrochloride 547757-23-3 NF-Κb IκB/IKK I kappa B kinase BMS 345541 Hydrochloride BMS345541 hydrochloride Inhibitor BMS345541 BMS-345541 BMS 345541 IKK IκB kinase BMS345541 Hydrochloride BMS 345541 hydrochloride BMS-345541 Hydrochloride inhibit inhibitor