Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BRD6688 is a selective HDAC2 inhibitor that acts by enhancing the learning and memory processes
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 28,000 | |||
5 mg | 在庫あり | ¥ 66,500 | |||
10 mg | 在庫あり | ¥ 117,500 | |||
25 mg | 在庫あり | ¥ 191,500 | |||
50 mg | 在庫あり | ¥ 264,000 | |||
100 mg | 在庫あり | ¥ 356,000 | |||
500 mg | 在庫あり | ¥ 682,000 |
説明 | BRD6688 is a selective HDAC2 inhibitor that acts by enhancing the learning and memory processes |
ターゲット&IC50 | HDAC1:21 nM , HDAC3:11.48 μM, HDAC2:100 nM |
In vivo | Mouse in-vivo study showed that BRD6688 was able to increase the histone acetylation (H4K12 and H3K9) in hippocampal CA1 neurons of CK-p25 mice. Moreove, the increased histone acetylation in brain served as a surrogate pharmacodynamic marker of HDAC engagement and was consistent with previously observed brain pharmacokinetic properties. In addition, BRD6688 rescued the cognitive deficits in CK-p25 mice, a model of neurodegeneration, in a Pavlovian fear conditioning behavioral assay[1]. |
分子量 | 282.34 |
分子式 | C16H18N4O |
CAS No. | 1404562-17-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: ≤2mg/ml
dimethyl formamide: 30mg/ml
DMSO: 50 mg/mL (177.09 mM)
You can also refer to dose conversion for different animals. 詳細
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BRD6688 1404562-17-9 Chromatin/Epigenetic DNA Damage/DNA Repair HDAC Histone deacetylases inhibit BRD 6688 BRD-6688 Inhibitor inhibitor