Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BRD7552 is an inducer of transcription factor PDX1, which increases insulin expression. BRD7552 increases PDX1 expression in mouse αTC cells but not βTC cells.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 8,000 | |||
2 mg | 在庫あり | ¥ 11,000 | |||
5 mg | 在庫あり | ¥ 18,000 | |||
10 mg | 在庫あり | ¥ 22,500 | |||
25 mg | 在庫あり | ¥ 51,500 | |||
50 mg | 在庫あり | ¥ 99,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 28,000 |
説明 | BRD7552 is an inducer of transcription factor PDX1, which increases insulin expression. BRD7552 increases PDX1 expression in mouse αTC cells but not βTC cells. |
In vitro | BRD7552 upregulates PDX1 expression in both primary human islets and ductal cells, and induces epigenetic changes in the PDX1 promoter consistent with transcriptional activation. BRD7552 increases PDX1 mRNA levels by 2- to 4-fold, with a maximal effect at 5 μM and the expression of MAFA. BRD7552 increases PDX1 expression in mouse αTC cells but not βTC cells. Treatment of PANC-1 cells with BRD7552 causes a dose-dependent increase in insulin mRNA expression. [1] |
分子量 | 711.63 |
分子式 | C33H33N3O15 |
CAS No. | 1137359-47-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 93 mg/mL (130.7 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: 93 mg/mL (130.7 mM)
You can also refer to dose conversion for different animals. 詳細
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