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T6793 |
BRD7552
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Others
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BRD7552 is an inducer of transcription factor PDX1, which increases insulin expression. BRD7552 increases PDX1 expression in mouse αTC cells but not βTC cells. |
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T14779 |
BRD7389
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SGK
,
FLT
,
Pim
,
CDK
,
S6 Kinase
,
DAPK
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BRD7389 is an inhibitor of RSK family kinase with IC50s of 1.5 μM, 2.4 μM, and 1.2 μM for RSK1, RSK2, and RSK3, respectively. |
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T7658 |
Dimethyl DL-Glutamate (hydrochloride)
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Others
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Dimethyl DL-glutamate is a cell-permeant glutamic acid derivative that enhances insulin release in response to glucose in isolated islets and in animal models of diabetes. |
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T83972 |
NOX-6-18
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GPR132 antagonist 1,GPR132-B-160 |
GPR
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NOX-6-18 (GPR132-B-160) is a highly potent and selective GPR132 antagonist with insulinotropic activity that modulates macrophage reprogramming in pancreatic islets and reduces weight gain. |
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T78097L |
Mazdutide acetate（2259884-03-0 free base）
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Mazdutide acetate（2259884-03-0 free base）,OXM-3 acetate,LY-3305677 acetate,IBI-362 acetate |
Glucagon Receptor
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Mazdutide acetate is a potent co-agonist of glucagon-like peptide (GLP-1R) and glucagon receptor (GCGR), a gastrin-regulating hormone analog.Mazdutide acetate stimulates insulin secretion from mouse pancreatic islets, an... |
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T15368L |
Galantide acetate
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Galantide acetate(138579-66-5 Free base) |
Neuropeptide Y Receptor
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Galantide acetate, a non-specific galanin receptor antagonist, is a peptide consisting of fragments of galanin and substance P. Galantide acetate recognizes two classes of galanin binding sites (KD<0.1 nM and ~6 nM) in t... |
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T71346 |
MS4
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MS4 is a novel glucocorticoid receptor (GR) agonist with anti-inflammatory activity and displaying reduced impact on islets. |
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T26172 |
S3QEL-2
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S3QEL2,S3QEL 2 |
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S3QEL-2 is a retrograde signaling modulator. It acts by strongly mitigating the oxidative stress-induced apoptosis that limits the yield of functional ß-cells from intact islets. |
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TP1519 |
Amylin (IAPP), feline
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Amylin (IAPP), feline is the peptide subunit of amyloid found in pancreatic islets of type 2 diabetic patients and in insulinomas. |
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T70113 |
ATM-1001
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ATM-1001 is an inhibitor of the cancer-associated tropomyosin 3.1 (Tpm3.1), suppressing glucose-stimulated insulin secretion (GSIS) from the pancreatic islets. |
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T71020 |
PF-04671536
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PF-04671536 is a highly potent and selective inhibitor of phosphodiesterase 8B (PDE8B) phosphodiesterase 8A (PDE8A). In primary human pancreatic islets, PF-04671536 increases insulin secretion in a glucose-dependent mann... |
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T11401 |
GKA50
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Others
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GKA50 stimulates insulin release from mouse islets of Langerhans and MIN6 cells. GKA50 shows significant glucose lowering in high fat fed female rats. GKA50 is a potent glucokinase activator (EC50=33 nM at 5 mM glucose). |
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T24169 |
Insulin B (22-30)
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Insulin (B22-B30) |
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Insulin B (22-30) is a peptide hormone produced by beta cells of the pancreatic islets, and it is considered to be the main anabolic hormone of the body. It is therefore an anabolic hormone, promoting the conversion of s... |
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T26868 |
BMS-986118
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BMS 986118 |
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BMS-986118 is a full agonist of GPR40, is a G-protein-coupled receptor expressed primarily in pancreatic islets and intestinal L-cells that has been a target of significant recent therapeutic interest for type II diabete... |
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T24168 |
Insulin B (20-30)
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Insulin (B20-B30) |
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Insulin B (20-30) is a peptide hormone produced by beta cells of the pancreatic islets, and it is considered to be the main anabolic hormone of the body. It is therefore an anabolic hormone, promoting the conversion of s... |
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TP1863 |
Glucagon (19-29), human
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Glucagon is a 29-amino-acid peptide hormone liberated in the alpha cells of the islets of Langerhans. Glucagon-producing alpha cells represent one of the earliest populations of detectable islet cells in the developing e... |
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T63019 |
GKA50 quarterhydrate
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GKA50 quarterhydrate is a potent glucokinase activator with an EC50 value of 33 nM. GKA50 quarterhydrate is a glucose-like activator of β-cell metabolism in rodent and human pancreatic islets and a Ca2+-dependent regulat... |
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TP1954 |
PHM-27 (human)
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Endogenous peptide product of human prepro-VIP and analog of porcine PHI-27; potent agonist for the human calcitonin receptor (EC50 = 11 nM). Transgenic mice expressing the human VIP/PHM 27 gene in pancreatic β-islets di... |
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T76028 |
Amylin (IAPP), feline TFA
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Amylin (IAPP), feline TFA, a 37-amino acid polypeptide derived from felines, stands as a principal secretion product of the pancreatic islets' β-cells. This regulatory peptide notably inhibits the secretion of insulin an... |
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T29154 |
WB403
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WB-403,WB 403 |
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WB403 is a TGR5 activator. WB403 significantly decreases fasting blood glucose, postprandial blood glucose and HbA1c, improves glucose tolerance in type 2 diabetic mice. WB403 increases pancreatic β-cells and restores th... |
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T21681 |
AACOCF3
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Arachidonyl trifluoromethyl ketone,Arachidonyltrifluoromethane |
Phospholipase
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AACOCF3 (Arachidonyl trifluoromethyl ketone) is a cell-permeable trifluoromethyl ketone analog of arachidonic acid. It is a potent and selective slow binding inhibitor of the 85-kDa cytosolic phospholipase A2 (cPLA2). By... |
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TP1662 |
Galanin Receptor Ligand M35
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The chimeric peptide M35 [galanin (1-13)-bradykinin(2-9) amide] is a high-affinity galanin receptor ligand acting as a galanin receptor antagonist in the rat spinal cord, rat hippocampus and isolated mouse pancreatic isl... |
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TP1301 |
Orexin A (human, rat, mouse)
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Orexin A human, rat, mouse, a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A human, rat, mouse has been used to study its effect on the functioning of porcine pancr... |
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T80149 |
GRPP (human)
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GRPP (human), a 30-amino-acid peptide derived from Gcg, modestly elevates plasma insulin levels while reducing plasma glucagon concentrations. However, GRPP (human) has no impact on insulin secretion within rat islets [1... |
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TP1302 |
Somatostatin
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Somatostatin, also known as growth hormone-inhibiting hormone, is a naturally-occurring peptide hormone of 14 or 28 amino acid residues that regulates the endocrine system. It is secreted by the D cells of the islets to ... |
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T74567 |
Phospholipid-PEG-Biotin (MW 10000)
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Phospholipid-PEG-Biotin (MW 10000 and 3400) is a derivative comprising a biotin and a phospholipid connected via a linear PEG linker. This compound is capable of interacting with avidinylated antibodies and is utilized f... |
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TP1044 |
Pancreatic Polypeptide, rat
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Rat pancreatic polypeptide |
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Pancreatic Polypeptide, rat is an agonist of NPY receptor, with high affinity at NPYR4. Pancreatic polypeptide (PP) is a 36-amino acid, C-terminally amidated peptide, and is a member of the PP-fold peptide family. It is ... |
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T74568 |
Phospholipid-PEG-Biotin (MW 20000)
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Phospholipid-PEG-Biotin (MW 20000 and MW 3400) is a derivative combining biotin and phospholipid via a linear PEG linker, capable of interacting with avidinylated antibodies. This compound facilitates the modification of... |
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T73610 |
Lipoprotein lipase
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Lipoprotein lipase, a multifunctional enzyme present in adipose tissue, heart, skeletal muscle, islets, and macrophages, plays a crucial role in normal lipoprotein metabolism, and the distribution and utilization of tiss... |
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T74565 |
Phospholipid-PEG-Biotin (MW 3400)
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Phospholipid-PEG-Biotin (MW 3400) is a derivative of phospholipid PEG, featuring a biotin and a phospholipid connected via a linear PEG linker. This compound has the capability to bind with avidinylated antibodies and is... |
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T74566 |
Phospholipid-PEG-Biotin (MW 5000)
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Phospholipid-PEG-Biotin (MW 5000), a derivative of phospholipid PEG, serves to modify the surfaces of liposomes, cells, and pancreatic islets for cell transplantation. This compound incorporates a phospholipid (a lipid f... |
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TP2071 |
Bay 55-9837
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Selective VPAC2 receptor agonist (EC50 values are 0.4, 100 and >1000 nM for VPAC2, VPAC1 and PAC1, respectively in a cAMP accumulation assay; IC50 values are 60, 8700 and >10000 nM for VPAC2, VPAC1 and PAC1, respectively... |
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T74563 |
Phospholipid-PEG-Biotin (MW 1000)
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Phospholipid-PEG-Biotin (MW 1000 and MW 3400) is a derivative of a phospholipid and PEG, featuring a biotin moiety and a phospholipid connected via a linear PEG linker. This compound, particularly with a molecular weight... |
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T74564 |
Phospholipid-PEG-Biotin (MW 2000)
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Phospholipid-PEG-Biotin (MW 2000), a biotin-labeled phospholipid PEG derivative, is designed for modifying the surfaces of liposomes, cells, and pancreatic islets intended for cell transplantation. This compound integrat... |
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T35627 |
Amylin (human) (trifluoroacetate salt)
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Amylin is a 37-residue peptide hormone secreted from pancreatic β-cells that reduces food intake, decreases glucagon secretion, slows gastric emptying, and increases satiety. It binds to amylin receptors with IC50 values... |
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T35598 |
Neuromedin U-25 (human) (trifluoroacetate salt)
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Neuromedin U (NMU) is a neuropeptide first demonstrated to drive smooth muscle contraction.1Translated as a 174 amino acid propeptide, NMU is cleaved to different lengths in different animals. It has diverse receptor-med... |
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T83928 |
DA ZP1
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DA ZP1 (diacetylated Zinpyr1), a highly sensitive fluorogenic Zn(II) sensor (KdZn2+= 0.6 nM), efficiently images and isolates pancreatic β-cells and β-like cells in vitro and purifies live stem cell-derived β-like cells.... |
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T35622 |
FKGK 18
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FKGK 18 is an inhibitor of group VIA (GVIA) calcium-independent phospholipase A2 (iPLA2). It inhibits GVIA iPLA2 by 99.9% at 0.091 mole fraction in a mixed micelle activity assay and is selective for GVIA iPLA2 over GIVA... |
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T36070 |
(±)5(6)-EET
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5(6)-EET is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes. In solution, 5(6)-EET degrades into 5,6-DiHET and 5(6)-δ-lactone, which can be converted to 5... |
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T35794 |
Kisspeptin-54 (human) (trifluoroacetate salt)
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Kisspeptin-54 is a peptide ligand of the orphan G protein-coupled receptor GPR54 (Kis = 1.81 and 1.45 nM for rat and human receptors, respectively).1 It is a 54 amino acid peptide encoded by the metastasis suppressor gen... |
