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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T6793 | BRD7552 | Others | |
BRD7552 is an inducer of transcription factor PDX1, which increases insulin expression. BRD7552 increases PDX1 expression in mouse αTC cells but not βTC cells. | |||
T12115 | MSC2360844 | PI3K | |
T8779 | HBT1 | GluR | |
HBT1 is an AMPA receptor potentiator that induces production of brain-derived neurotrophic factor (BDNF) and exhibits little agonistic effect in primary neurons. HBT1 binds to ligand-binding domain of AMPA-R in glutamate... | |||
T4277 | Osilodrostat | LCI699 | Glucocorticoid Receptor , Others , Hydroxylase |
Osilodrostat (LCI699) (LCI699) is an effective inhibitor of human 11β-hydroxylase (IC50: 2.5 nM) and aldosterone synthase (IC50: 0.7 nM). | |||
TD0101 | AQC | 6-Aminoquinolyl-N-hydroxysccinimidyl carbamate | Others |
AQC (6-Aminoquinolyl-N-hydroxysccinimidyl carbamate) (6-Aminoquinolyl-N-hydroxysccinimidyl carbamate) is a reagent for the fluorescence detection of amino acid or protein sequence by HPLC. AQC reacts with primary and sec... | |||
T9149 | 2BAct | 2B-Act,2B Act | PERK |
2BAct is a novel eif2b activator, preventing neurological defects caused by a chronic integrated stress response | |||
T3978 | Linerixibat | GSK2330672,Iinerixibat | HBV |
Linerixibat (GSK2330672) is a highly effective, nonabsorbable ASBT inhibitor (IC50: 42 ± 3 nM). It can lower glucose in an animal model of type 2 diabetes and shows excellent developability properties. | |||
T1684 | Nitisinone | NTBC,SC0735,Nitisone | Others , Reactive Oxygen Species |
Nitisinone (SC0735)(SC0735) is an enzyme 4-hydroxyphenylpyruvate dioxygenase inhibitor. | |||
T3184 | Kevetrin hydrochloride | Thioureidobutyronitrile HCl,thioureido butyronitrile hydrochloride,4-Isothioureidobutyronitrile hydrochloride | Mdm2 , p53 |
Kevetrin hydrochloride (4-Isothioureidobutyronitrile hydrochloride) is a small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity. | |||
T21510 | PSI | Proteasome | |
PSI is a proteasome inhibitor. | |||
T25006 | AGI-14100 | AGI 14100 | Dehydrogenase |
AGI-14100 is a novel and orally available mIDH1 inhibitor.AGI-14100 is used for the treatment of primary human myeloid leukemia. | |||
T34914 | Trabodenoson | INNO-8875,INO-8875,PJ875,PJ-875,INNO 8875,INNO8875,PJ 875 | Adenosine Receptor |
Trabodenoson (INO-8875) is a selective and potent adenosine A1 receptor agonist, an adenosine analog, for the study of primary open-angle glaucoma. | |||
T77621 | Z16078526 | p38 MAPK , Mitochondrial Metabolism | |
Z16078526 enhances thermogenesis in mice by inducing endogenous Ucp1 expression, promoting p38 MAPK phosphorylation, and stimulating lipolysis in primary mouse brown adipocytes. Additionally, it activates thermogenic gen... | |||
T24865 | Tenivastatin | L-654969,L654969,Simvastatin acid,L 654969,Simvastatin hydroxy acid | ROS , HMG-CoA Reductase |
Tenivastatin (Simvastatin acid) is an anti-hyperlipidemic HMG-CoA reductase inhibitor that inhibits the production of reactive oxygen species (ROS) and can be used in the study of primary hyperlipidemia. | |||
T18902 | 6-FAM | 6-Carboxyfluorescein | Others |
6-Carboxyfluorescein (6-FAM) contains a carboxylic acid functional group, facilitating reactions with primary amines through carbodiimide activation. | |||
T7317 | CU-CPT-9a | TLR | |
CU-CPT-9a is a potent TLR8 inhibitor (IC50 : 0.5 nM), that suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells- | |||
T24159 | IHR-1 | IHR 1 | Smo |
IHR-1 is a Potent Smo antagonist (IC50 = 7.6 nM). Selectively inhibits Hedgehog signaling over Wnt and Notch signaling pathways. Blocks Smo accumulation in primary cilium in vitro. | |||
T7363 | Ibuprofen Piconol | U75630 | Others |
Ibuprofen Piconol (U75630) is a non-steroidal, anti-inflammatory (NSAID) agent for the topical relief of primary thermal burns and sunburns.Ibuprofen piconol is a Pyridyl ester of ibuprofen. | |||
T21743L | Beta-Lipotropin (1-10), porcine Acetate | Beta-Lipotropin (1-10), porcine Acetate(77875-68-4 Free base) | Others |
Beta-Lipotropin (1-10), porcine Acetate (Beta-Lipotropin ) (beta-LPH) was found to contain within its C-terminal sequence the primary structure of these peptides. | |||
T61702 | SRI-37240 | ||
SRI-37240 is a powerful inhibitor of premature termination codons (PTCs). It effectively suppresses CFTR nonsense mutations and induces changes in cellular translation termination at PTCs in HEK293T cells. Additionally, ... | |||
T3106 | C-DIM12 | Apoptosis , Others | |
C-DIM12 induced expression of Nurr1-regulated genes. C-DIM12 increased expression of transfected human Nurr1, induced Nurr1 protein expression in primary dopaminergic neurons and enhanced neuronal survival from exposure ... | |||
T23215L | (R)-3,4-DCPG HCl | (R)-3,4-DCPG HCl(201730-10-1 Free base) | GluR |
(R)-3,4-DCPG HCl is a potent and selective mGlu8a receptor agonist that activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord. | |||
T77717 | AST 7062601 | AST070 | Others |
AST 7062601 is a potent Ucp1 inducer that promotes endogenous Ucp1 expression in primary mouse brown adipocytes.AST 7062601 may be useful in the study of obesity. | |||
T34573 | SCH-900271 | SCH 900271 | AChR |
SCH-900271 is a potent nicotinic acid receptor for the treatment of dyslipidaemia and is commonly used in the study of mixed hyperlipidaemia and primary hypercholesterolaemia. | |||
T18895 | 5(6)-FAM SE | 5(6)-Carboxyfluorescein N-hydroxysuccinimide ester | Others |
5(6)-FAM SE (5(6)-Carboxyfluorescein N-hydroxysuccinimide ester) is an amine-reactive green fluorescent dye. 5(6)-FAM SE is widely used for labeling proteins or other molecules that contain a primary or secondary aliphat... | |||
T18990 | Fluorescamine | Ro 20-7234 | Others |
Fluorescamine (Ro 20-7234) ( Ro 20-7234) is not fluorescent itself but reacts with primary amines to form highly fluorescent products. It is used to detect amines and peptides. | |||
TP1915 | Boc-MLF | Others | |
Antagonist of formyl peptide receptor 1 (FPR1). Reduces superoxide production induced by fMLF with an EC50 of 0.63 μM. Almost completely blocks fMLF-stimulated primary granule exocytosis. | |||
T3069 | AZD-1480 | JAK | |
AZD1480 is a novel ATP-competitive JAK2 inhibitor (IC50: 0.26 nM), selectivity act against Tyk2 and JAK3, and to a smaller extent against JAK1. AZD1480 has been used in trials studying the treatment of Solid Malignancies... | |||
T25125 | AZA197 | AZA 197,AZA-197 | CDK |
AZA197 (AZA-197) is a selective Cdc42 inhibitor. It acts by inhibiting primary colon cancer growth and prolonging survival in a preclinical mouse xenograft model by downregulation of PAK1 activity. | |||
T18893 | 5(6)-Carboxyfluorescein | 5-(and-6)-Carboxyfluorescein mixed isomers,5(6)-FAM | Others |
5(6)-Carboxyfluorescein (5-(and-6)-Carboxyfluorescein mixed isomers) contains a carboxylic acid that can be used to react with primary amines via carbodiimide activation of the carboxylic acid. | |||
T64351 | GI-560192 | RL-0070933 | Smo |
GI-560192 (RL-0070933) is a potent smo cilial modulator with an EC50 value of 0.02 µM. GI-560192 modulates the translocation and/or accumulation of smoothened to the primary cilia by hedgehog signaling pathway. | |||
T61151 | Beclobrate | Sgd 24774 | Others |
Beclobrate (Sgd 24774) is a novel orally available fibric acid derivative that has shown significant lipid and cholesterol-lowering activity in rodents and may be used in the study of primary hyperlipoproteinemia. | |||
T63042 | NDB | FXR | |
NDB is a selective and potent hFXRα antagonist that inhibits GW4064-stimulated FXR/RXR interactions and FXRα target gene expression in primary mouse hepatocytes.NDB is used in the study of diabetes. | |||
T0255 | Clomipramine hydrochloride | Clomipramine HCl,Anafranil | Dopamine Receptor , 5-HT Receptor , Serotonin Transporter , Norepinephrine , GST |
Clomipramine hydrochloride (Anafranil) is a tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demeth... | |||
T64334 | Glycolithocholic acid, sodium salt | Others | |
Glycolithocholic acid sodium salt, the sodium form of Glycolithocholic acid, is a glycine-conjugated secondary bile acid utilized in diagnosing ulcerative colitis (UC), non-alcoholic steatohepatitis (NASH), and primary s... | |||
T72984 | (Rac)-SHIN2 | Others | |
(Rac)-SHIN2 is a serine hydroxymethyltransferase (SHMT) inhibitor that enhances NOTCH1-driven in vivo survival of primary T-ALL in mice and can be used to study T-cell acute lymphoblastic leukemia (T-ALL). | |||
T18728 | Sulfo-SMCC sodium | Others | |
Sulfo-SMCC sodium, a widely utilized non-cleavable, hetero-bifunctional crosslinker for antibody-drug conjugates (ADCs), features both N-hydroxysuccinimide (NHS) ester and maleimide groups. These functionalities enable i... | |||
T60325 | Viloxazine | Emovit,Viloxazin | 5-HT Receptor , Norepinephrine |
Viloxazine (Viloxazin) (Viloxazin) is a dual-action compound that functions as a norepinephrine reuptake inhibitor and exhibits potent agonistic activity towards 5-HT 2C receptors while acting as an antagonist for 5-HT 2... | |||
T9853 | STING activator Compound 53 | STING | |
STING activator Compound 53 based on an oxindole core structure demonstrated robust on-target functional activation of STING (human EC50 185 nM) in immortalised and primary cells and a cytokine induction fingerprint cons... | |||
T14965 | Ciliobrevin D | ATPase , Hedgehog/Smoothened | |
Ciliobrevin D is a AAA+ ATPase motor cytoplasmic dynein inhibitor. Ciliobrevin D inhibits Hedgehog (Hh) signaling and primary cilia formation and it also inhibits dynein-dependent microtubule gliding and ATPase activity ... | |||
T19450 | N-desmethyl Enzalutamide | N-desmethyl MDV 3100 | Androgen Receptor |
N-desmethyl Enzalutamide (N-desmethyl MDV 3100) is the active Enzalutamide metabolite.It is the active metabolite of Enzalutamide. N-desmethyl Enzalutamide demonstrates primary and secondary pharmacodynamics of similar p... | |||
T10981 | DCZ0415 | Apoptosis , Others , NF-κB | |
DCZ0415 induces antimyeloma activity in vitro, in vivo and in primary cells of drug-resistant myeloma patients. DCZ0415 is a potent TRIP13 inhibitor that can impair the repair of non-homologous end junctions and inhibit ... | |||
T16510 | PF-915275 | Dehydrogenase | |
The dose-dependent effect of PF-915275 on the conversion of cortisone to cortisol in primary human and monkey hepatocytes (EC50: 20 and 100 nM, respectively). PF-915275 is an effective and selective human 11β-hydroxyster... | |||
T16376 | Odevixibat | A4250 | Others |
Odevixibat (A4250) is an effective, selective and orally active ileal bile acid transporter inhibitor. Odevixibat has the potential for the treatment of primary biliary cirrhosis. Odevixibat reduces cholestatic liver and... | |||
T18967 | Dansyl chloride | DNSCl | Others |
Dansyl chloride (DNSC-l) reacts with primary amino groups in both aliphatic and aromatic amines to produce stable blue- or blue-green-fluorescent sulfonamide adducts. It is widely used to modify amino acids, specifically... | |||
T36866 | 3-Deazauridine | NSC 126849 | Nucleoside Antimetabolite/Analog |
3-Deazauridine (NSC-126849) is a structural analog of uridine that inhibits the biosynthesis of Cytidine-5'-Triphosphate by competitive inhibition of Cytidine Triphosphate synthetase which is considered to be the primary... | |||
T76700 | Simtuzumab | GS 6624,AB 0024 | Monoamine Oxidase |
Simtuzumab is a monoclonal antibody against lysyl oxidase-like protein 2 (LOXL2). Simtuzumab can be used to treat primary sclerosing cholangitis (PSC) and is not effective in patients with bridging fibrosis or compensato... | |||
T60372 | ALDH3A1-IN-1 | ||
ALDH3A1-IN-1 (Compound 18) is a potent ALDH3A1 inhibitor with an IC 50 of 1.61 μM. ALDH3A1-IN-1 is more potent than DEAB against patient-derived primary prostate tumor epithelial cells, as single agents or in combination... | |||
TP1913L1 | BA 1 acetate(183241-31-8 free base) | Bombesin Receptor | |
BA 1 acetate is a potent bombesin receptor agonist (IC50 values are 0.26, 1.55 and 2.52 nM for BB1, BB2 and BB3 respectively). Enhances glucose transport in obese and diabetic primary myocytes. Also stimulates NCI-H1299 ... | |||
T60857 | MKK7-COV-9 | Others | |
MKK7-COV-9 is a selective and potent covalent inhibitor of MKK7 with inhibitory effects on MKK7-induced protein-protein interactions.MKK7-COV-9 interrupts the activation of primary B-cells in response to LPS.MKK7-COV-9 s... |
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T31964 | Glycolithocholic acid | Lithocholic acid glycine conjugate,Lithocholylglycine | Others |
Glycolithocholic acid (Lithocholic acid glycine conjugate) is a glycine conjugate of lithocholic acid. | |||
T1882 | Meisoindigo | N-Methylisoindigotin,Methylisoindigotin,Natura-α,Dian III | Apoptosis |
Meisoindigo (Natura-α) is a derivative of indigo natural, might induces apoptosis and myeloid differentiation of acute myeloid leukemia (AML). | |||
T2977 | Vanillin acetate | Acetovanillin,Acetylvanillin,4-Formyl-2-methoxyphenyl acetate,4-Acetoxy-3-methoxybenzaldehyde | Others |
Acetylvanillin is a derivative of Vanillin, the primary component found in vanilla bean extract. | |||
T19931 | Gentisein | NSC 329491,NSC329491,NSC-329491 | Serotonin Transporter |
Gentisein (NSC-329491), a primary metabolite of Mangiferin, exhibits significant inhibition of serotonin uptake, demonstrating potency with an IC50 value of 4.7 µM[1][2]. | |||
T4S0779 | D-tetrahydropalmatine | Others , Dopamine Receptor | |
D-Tetrahydropalmatine is a organic cation transporter 1 (OCT1) inhibitor, it can obviously inhibit the uptake of monocrotaline (MCT) in MDCK-hOCT1 cells and isolate rat primary hepatocytes, and attenuate the viability re... | |||
T4759 | Urocanic acid | 4-Imidazoleacrylic acid | Others , Endogenous Metabolite |
Urocanic acid (4-Imidazoleacrylic acid), synthesized in the epidermis, functions as a primary absorber of ultraviolet (UV) radiation in mammalian skin. | |||
T22300 | Creatine monohydrate | Methylguanidoacetic acid monohydrate | Others , Endogenous Metabolite |
Creatine monohydrate (Methylguanidoacetic acid monohydrate) is a key player in the phosphagen energy system, especially in muscle and the brain. Creatine monohydrate is the primary source of ATP during high-intensity, sh... | |||
T3090 | Abietic Acid | Rosin Acid,L-Abietic acid,Sylvic acid,Abietate | MMP , Lipoxygenase , Antibacterial , PPAR |
Abietic Acid (Sylvic acid) is the primary component of resin acid isolated from rosin. | |||
T4333 | Quinine dihydrochloride | Quinine bimuriate | Others |
Quinine dihydrochloride (Quinine bimuriate) is a primary alkaloid of various species of Cinchona (Rubiaceae). It is also an antimalarial and muscle relaxant (skeletal). | |||
T0856 | Dehydroisoandrosterone 3-acetate | Dehydroepiandrosterone 3-acetate,Dehydroepiandrosterone acetate,Prasterone acetate,DHEA acetate,androstenolone acetate | Androgen Receptor |
Dehydroisoandrosterone 3-acetate (Prasterone acetate) is a primary C19 steroid generated by the adrenal cortex. | |||
TN1933 | Mitraphylline | IL Receptor , TNF , NF-κB | |
Mitraphylline has antiproliferative effects on human glioma and neuroblastoma cell lines. It also has anti-inflammatory activity, it inhibits lipopolysaccharide-mediated activation of primary human neutrophils. | |||
T3670 | Forsythiaside A | Forsythiaside,Forsythoside A | Others |
Forsythiaside A (Forsythiaside) has antimicrobial, anticomplementary, anti-inflammatory and antiendotoxin activities. Forsythiaside A inhibits Infected cells was confirmed by infecting primary chicken embryo kidney cells... | |||
T6395 | Astragaloside A | Astragalin A,Astramembrannin I | Calcium Channel |
Astragaloside A (Astramembrannin I) (Astragaloside IV) is the primary pure saponin isolated from Astragalus membranaceus, which has been widely used for the therapy of cardiovascular diseases. | |||
T3761 | 1-Octacosanol | n-Octacosanol,Montanyl alcohol,Cluytyl alcohol,Octacosanol,Octacosyl alcohol,Octanosol | Others |
1-Octacosanol (Octanosol) is a straight-chain aliphatic 28-carbon primary fatty alcohol that is used as a nutritional supplement. It is reported to possess cholesterol-lowering effects, antiaggregatory properties, cytopr... | |||
T20091 | Stearamide | Stearic acid amide,NSC 66462,NSC66462,NSC-66462 | |
Stearamide(Stearic acid amide) is a primary fatty acid amide that is cytotoxic and fish toxic and can be used to increase the properties of nanoparticles. | |||
T2926 | Schizandrin A | P450 , Virus Protease , Autophagy | |
Schisandrin A, a primary active component extracted from the traditional Eastern medicine Schisandra chinensis, inhibits CYP3A activity, with an IC50 of 6.60 μM and a Ki of 5.83 μM. | |||
TN1480 | Cephaeline | Virus Protease , Influenza Virus , HIF | |
Cephaeline was highly active against protected primary CLL cells (relative IC50's 35nM ) and acted by repressing HIF-1α± and disturbing intracellular redox homeostasis. | |||
T6S0920 | 2"-O-Galloylhyperin | 2''-O-Galloylhyperin,Q-100605,FT-0689359 | Others |
2"-O-Galloylhyperin (FT-0689359) found in Pyrola. It increases ruminal fiber fermentability by formed wall-bound lignin in primary maize cell walls. | |||
T4884 | Alpha-D-glucose | α-D-Glucose,alpha-Glucose,α-Dextrose | Others , Endogenous Metabolite |
alpha-D-glucose (α-Dextrose) is a primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutri... | |||
T2963 | Cholic Acid | Cholanic acid,Cholate,Colalin | Endogenous Metabolite |
Cholic Acid (Cholate) is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. Cholic acid facilitates fat absorption and cholesterol excretion. | |||
T13693 | Fibrin | Others | |
Fibrin, the primary constituent of blood clots, is an insoluble protein essential for coagulation. Isolated from bovine blood, this protein is notably synthesized in response to bleeding. | |||
T13589 | Caesappanin C | Others | |
Caesappanin C, extracted from the heartwood of Indonesian Caesalpinia sappan L., shows strong proliferation stimulating activity against the primary osteoblastic cells in vitro. | |||
T11060 | DMAPT | Dimethylamino Parthenolide | NF-κB |
DMAPT (Dimethylamino Parthenolide) is a water-soluble analogue of Parthenolide (PTL). It is an orally active NF-κB inhibitor with an LD50 of 1.7 μM on primary acute myeloid leukemia cells. | |||
TN6891 | 1-Hexanol | hexan-1-ol | Others |
1-Hexanol (hexan-1-ol) is a natural product.1-Hexanol, a primary alcohol, is a surfactant that can be employed in industrial processes to enhance interfacial properties[1]. 1-Hexanol uncouples mitochondrial respiration b... | |||
T3768 | Epifriedelanol | Epifriedelinol | Others |
Epifriedelanol (Epifriedelinol) suppresses adriamycin-induced cellular senescence, replicative senescence in human fibroblasts (HDFs) and HUVECs. Because of Epifriedelanol can reduce cellular senescence in human primary ... | |||
T5S1708 | Dendrobine | Others , Influenza Virus | |
1. Dendrobine has a slight but demonstrable analgesic and antipyretic action. 2. Dendrobine produces moderate hyperglycemia, diminishes cardiac activity in large doses, lowers the blood pressure. 3. Dendrobine on the ele... | |||
T0887 | D-Glucose | Dextrose,Glucopyranose,Grape sugar,D(+)-Glucose | Endogenous Metabolite |
D-Glucose (Glucopyranose) is a primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient... | |||
T3800 | Typhaneoside | Aervitrin | Others , Autophagy |
Typhaneoside (Aervitrin) is a flavonoid glycoside plant extract with potential ability to treat primary dysmenorrhea through the Shaofu Zhuyu decoction. | |||
T3674 | Hydroxysafflor yellow A | HSYA,Safflomin A | TGF-beta/Smad |
Hydroxysafflor yellow A (Safflomin A) inhibited adipogenesis by increasing HSL promoter activities. Hydroxysafflor yellow A can effectively protect the liver from long-term alcohol injury by enhancing antioxidant capacit... | |||
T2598 | Thymopentin | TP5 | Estrogen/progestogen Receptor , Endogenous Metabolite |
Synthetic pentapeptide corresponding to the amino acids 32-36 of thymopoietin and exhibiting the full biological activity of the natural hormone. Thymopentin (TP5) is an immunomodulator which has been studied for possibl... | |||
T0076 | Paliperidone | 9-hydroxyrisperidone | Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor , Histamine Receptor |
Paliperidone (9-hydroxyrisperidone)(Invega) is used as an atypical antipsychotic. It applies to the acute and maintenance treatment of schizophrenia. Chemically, paliperidone is the primary active metabolite of the older... | |||
T37886 | 1-Heptadecanol | Antibacterial | |
1-Heptadecanol is a long-chain primary alcohol with antibacterial activity from Solena amplexicaulis leaves[1]. [1]. Soumendranath Chatterjee, et al. Antibacterial Activity of Long-Chain Primary Alcohols from Solena ampl... | |||
TCS2070 | Homogentisic acid | 2,5-dihydroxyphenylacetic acid,Homogentisinic Acid,Melanic acid | Antioxidant , Endogenous Metabolite |
1. Homogentisic acid (2,5-dihydroxyphenylacetic acid) shows interesting antioxidant and antiradical activities, and protective effect against thermal-cholesterol degradation, comparable to those of well known antioxidant... | |||
T5234 | Glycoursodeoxycholic acid | Ursodeoxycholylglycine,GUDCA | Others , Endogenous Metabolite |
Glycoursodeoxycholic acid (Ursodeoxycholylglycine) is an acyl glycine and a bile acid-glycine conjugate. It is a secondary bile acid produced by the action of enzymes existing in the microbial flora of the colonic enviro... | |||
T5S2129 | Sciadopitysin | TNF , NF-κB | |
Sciadopitysin may prevent the development of diabetic osteopathy, it exerts its therapeutic effects via upregulation of mitochondrial biogenesis.Sciadopitysin shows protective effects on antimycin A-induced toxicity in o... | |||
T4843 | 2,2-Dihydroxyacetic acid | Formylformic acid,Glyoxylic acid monohydrate | Others , Endogenous Metabolite |
2,2-Dihydroxyacetic acid (Formylformic acid) is an intermediate in the glyoxalate cycle, which enables certain organisms to convert fatty acids to carbohydrates.2,2-Dihydroxyacetic acid has been found to be associated wi... | |||
T5S2283 | Sesamolin | p38 MAPK , Caspase , JNK | |
1. Sesamolin and Sesamin has neuroprotective effect. 2. Sesamolin protects microglia against H2O2-induced cell injury, by inhibiting of p38 MAPK and caspase-3 activation and ROS production. 3. Sesamolin and Sesamin can s... | |||
T2532 | Tauroursodeoxycholate | Taurolite,Tauroursodeoxycholic Acid,UR 906,Ursodeoxycholyltaurine,TUDCA | Apoptosis , ERK , P450 , Caspase , Endogenous Metabolite |
Tauroursodeoxycholate (UR 906), also known as ursodoxicoltaurine, is a highly hydrophilic tertiary bile acid that is produced in humans at a low concentration. Tauroursodeoxycholate is the more hydrophilic form of ursode... | |||
T5287 | N-Acetyl-L-aspartic acid | AC-ASP-OH,N-Acetylaspartic acid | Others , Endogenous Metabolite |
N-Acetyl-L-aspartic acid (AC-ASP-OH) is a derivative of aspartic acid. It is the second most concentrated molecule in the brain after the amino acid glutamate. It is synthesized in neurons from the amino acid aspartate a... | |||
T2163 | Dihydrocapsaicin | CCRIS1589,6,7-Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide | Others , TRP/TRPV Channel |
Dihydrocapsaicin (CCRIS1589) is isolated from Capsicum fruit. Capsaicin is the primary active component of the heat and pain-eliciting lipid soluble fraction of the Capsicum pepper. Like capsaicin, dihydrocapsaicin is an... | |||
T19623 | α-Muricholic acid | AChR | |
α-Muricholic acid is the most abundant primary bile acid in rodents. | |||
T13520 | 6-Hydroxymelatonin | Others | |
6-Hydroxymelatonin is a primary metabolic of Melatonin, which is metabolized by CYP 1A2. | |||
TN6536 | Decuroside I | ||
Decuroside I shows weak inhibiting activity against the primary and secondary wave aggregation of human platelet. | |||
TN1581 | Dihydroguaiaretic acid | COX , DNA/RNA Synthesis | |
Dihydroguaiaretic acid has antioxidative activity, can significantly protect primary cultured neuronal cells against glutamate-induced oxidative stress. | |||
T19186 | Aldosterone | Others | |
Aldosterone is the primary mineralocorticoid. Aldosterone is synthesized and secreted in response to renin-angiotensin system activation or high dietary potassium by the zona glomerulosa of the adrenal cortex. | |||
TN1751 | Hydroxycitric acid | ERK , p38 MAPK , Fatty Acid Synthase | |
(-)-Hydroxycitric acid (HCA) can inhibit fat synthesis and reduces food intake, the primary mechanism of action of HCA appears to be related to its ability to act as a competitive inhibitor of the enzyme ATP-citrate lyas... | |||
TN2037 | Paeonilactone C | Others | |
Paeonilactone C significantly protects primary cultures of rat cortical cells against H2O2-induced neurotoxicity. | |||
TN6657 | 4-(Dimethylamino)cinnamaldehyde | ||
4-Dimethylaminocinnamaldehyde is a photometric reagent for primary aromatic amines. The 4-(dimethylamino)cinnamaldehyde assay is currently used to quantify proanthocyanidin (PAC) content in cranberry products. | |||
T40741 | Dracorhodin | ||
Dracorhodin, the primary constituent found in the sanguis draconis extract, is a flavylium compound classified within the anthocyanin family. Notably, dracorhodin possesses the ability to elicit vasodilation. | |||
TN5169 | Traxillaside | 香榧 | Others |
Traxillaside has significant neuroprotective activities against glutamate-induced toxicity in primary cultures of rat cortical cells . | |||
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カタログ番号 | 製品名 | Species | Expression System |
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TMPK-00300 | CD5 Protein (Primary Amine Labeling), Mouse, Recombinant (His), Biotinylated | Mouse | HEK293 Cells |
CD5: a type I transmembrane protein found on T cells, thymocytes, and some B cells that is a ligand for CD72 and is involved in cellular activation or adhesion; expressed in B-cell chronic lymphocytic leukemia and T-cell... | |||
TMPK-00006 | CD24 Protein (Primary Amine Labeling), Human, Recombinant (mFc), Biotinylated | Human | HEK293 Cells |
CD24 is a sialoglycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts. It is also expressed on neutrophils and neutrophil precursors from the myelocyte stage onwards. The potential fo... | |||
TMPK-00100 | CD7 Protein (Primary Amine Labeling), Mouse, Recombinant (hFc), Biotinylated | Mouse | HEK293 Cells |
CD7, also known as Leu-9, is an approximately 40 kDa glycosylated and palmitoylated transmembrane protein in the immunoglobulin superfamily.CD7 is expressed on T cells, NK cells , myeloid progenitor cells, and CD19 B pro... | |||
TMPK-00522 | PSMA Protein (Primary Amine Labeling), Cynomolgus, Recombinant (His), Biotinylated | Cynomolgus | HEK293 Cells |
Prostate-specific membrane antigen (PSMA) is an enzyme that in humans is encoded by the FOLH1 (folate hydrolase 1) gene, also known as Glutamate carboxypeptidase II (GCPII). Human PSMA is highly expressed in the prostate... | |||
TMPK-01245 | GDF-15 Protein (Primary Amine Labeling), Mouse, Recombinant (hFc), Biotinylated | Mouse | HEK293 Cells |
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and t... | |||
TMPK-01136 | CD3 epsilon/CD3e Protein (Primary Amine Labeling), Cynomolgus, Recombinant (His), Biotinylated | Cynomolgus | HEK293 Cells |
CD3E, is a single-pass type I membrane protein.CD3 (cluster of differentiation 3) T cell co-receptor helps to activate both the cytotoxic T cell (CD8 naive T cells) and also T helper cells (CD4 naive T cells). It consist... | |||
TMPK-00096 | FGF-10 Protein (Primary Amine Labeling), Human, Recombinant, Biotinylated | Human | E. coli |
Fibroblast growth factor 10 (FGF10) regulates multiple stages of structural lung morphogenesis, cellular differentiation, and the response to injury. As a driver of lung airway branching morphogenesis, FGF10 signaling de... | |||
TMPK-00142 | APRIL/TNFSF13 Trimer Protein (Primary Amine Labeling), Human, Recombinant (His & Flag), Biotinylated | Human | HEK293 Cells |
The APRIL (a proliferation-inducing ligand), also known as TNFSF13, TALL2, TRDL1, and CD256, is a member of the TNF ligand superfamily.Both APRIL and its close relative BAFF bind and signal through the TNF superfamily re... | |||
TMPK-00080 | CD27 Ligand/CD70 Trimer Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated | Human | HEK293 Cells |
CD70, also named CD27 ligand (CD27L), is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and has been designated TNFSF7. CD70 is a cytokine that binds to CD27. Plays a role in T-cell activa... | |||
TMPK-00582 | MASP2 Protein (Primary Amine Labeling), Rat, Recombinant (His), Biotinylated | Rat | E. coli |
MASP2 Protein (Primary Amine Labeling), Rat, Recombinant (His), Biotinylated is expressed in E. coli expression system with C-His tag. The predicted molecular weight is 46.7 kDa and the accession number is A2VCV7. | |||
TMPK-00406 | TLR3 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated | Human | HEK293 Cells |
TLR3 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 78.7 kDa and the accession number is Q6PCD4. | |||
TMPK-00675 | CD24 Protein (Primary Amine Labeling), Cynomolgus, Recombinant (hFc), Biotinylated | Cynomolgus | HEK293 Cells |
CD24 is a sialoglycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts. It is also expressed on neutrophils and neutrophil precursors from the myelocyte stage onwards. The potential fo... | |||
TMPK-00502 | PADI4 Protein (Primary Amine Labeling), Cynomolgus, Recombinant (His), Biotinylated | Cynomolgus | E. coli |
Peptidylarginine deiminase type4 (PADI4) was firstly identified as a non-MHC RA genetic risk factor. Furthermore, PADI4 risk allele possessed the association with bone damage regardless of anti citrullinated peptide anti... | |||
TMPK-00341 | ALCAM Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated | Human | HEK293 Cells |
Brain metastasis (BM) in non-small-cell lung cancer (NSCLC) has a very poor prognosis. Recent studies have demonstrated the importance of cell adhesion molecules in tumor metastasis.Elevated levels of ALCAM expression pr... | |||
TMPK-01238 | PADI4 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated | Human | E. coli |
Peptidylarginine deiminase type4 (PADI4) was firstly identified as a non-MHC RA genetic risk factor. Furthermore, PADI4 risk allele possessed the association with bone damage regardless of anti citrullinated peptide anti... | |||
TMPK-00076 | IL-18 Protein (Primary Amine Labeling), Human, Recombinant, Biotinylated | Human | E. coli |
Interleukin (IL)-18 was originally discovered as a factor that enhanced IFN-γ production from anti-CD3-stimulated Th1 cells, especially in the presence of IL-12. Upon stimulation with Ag plus IL-12, naïve T cells develop... | |||
TMPK-01210 | DLL3 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated | Human | HEK293 Cells |
Delta-like protein 3 (DLL3) is a transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands. DLL3 inhibits primary neurogenesis. May be required to divert neurons along a specific differe... | |||
TMPK-00937 | CKAP4 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated | Human | E. coli |
Cytoskeleton-associated protein 4 (CKAP4) is located in the rough endoplasmic reticulum (ER) and plays an important role in stabilizing the structure of ER. Meanwhile, CKAP4 is also found to act as an activated receptor ... | |||
TMPK-00005 | CD24 Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated | Human | HEK293 Cells |
CD24 is a sialoglycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts. It is also expressed on neutrophils and neutrophil precursors from the myelocyte stage onwards. The potential fo... | |||
TMPK-00410 | AXL Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated | Human | HEK293 Cells |
Axl, a member of the TAM (Tyro3, Axl, Mer) family, and its inhibitors can specifically break the kinase signaling nodes, allowing advanced patients to regain drug sensitivity with improved therapeutic efficacy. Overexpre... | |||
TMPK-01224 | CDH17 Protein (Primary Amine Labeling), Mouse, Recombinant (His), Biotinylated | Mouse | HEK293 Cells |
Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating... | |||
TMPK-00482 | TSLP Protein (Primary Amine Labeling), Cynomolgus, Recombinant (His), Biotinylated | Cynomolgus | HEK293 Cells |
Thymic Stromal Lymphopoietin (TSLP) was originally identified as an activity from the conditioned medium of a mouse thymic stromal cell line that promoted the development of B cells. Cytokine that induces the release of ... | |||
TMPK-00371 | PSMA Protein (Primary Amine Labeling), Mouse, Recombinant (His), Biotinylated | Mouse | HEK293 Cells |
Prostate-specific membrane antigen (PSMA) is an enzyme that in humans is encoded by the FOLH1 (folate hydrolase 1) gene, also known as Glutamate carboxypeptidase II (GCPII). Human PSMA is highly expressed in the prostate... | |||
TMPK-00104 | HMGB1 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated | Human | HEK293 Cells |
High-mobility group box 1 (HMGB1) is a ubiquitous nuclear protein that promotes inflammation when released extracellularly after cellular activation, stress, damage or death. HMGB1 operates as one of the most intriguing ... | |||
TMPK-00204 | FGL1 Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated | Human | HEK293 Cells |
Fibrinogen-like protein 1 (FGL-1) is a protein that is structurally related to fibrinogen. In humans, FLG-1 is encoded by the FGL1 gene.Fibrinogen-like protein 1 is a member of the fibrinogen family of proteins, which al... | |||
TMPK-00662 | PD-L1 Protein (Primary Amine Labeling), Cynomolgus/Rhesus macaque, Recombinant (His), Biotinylated | Cynomolgus,Rhesus | HEK293 Cells |
B7-H1, also known as PD-L1 and CD274, is an approximately 65 kDa transmembrane glycoprotein in the B7 family of immune regulatory molecules. PD-L1 has been identified as the ligand for the immunoinhibitory receptor progr... | |||
TMPK-01026 | MSLN/Mesothelin Protein (Primary Amine Labeling), Mouse, Recombinant (His), Biotinylated | Mouse | HEK293 Cells |
MSLN/Mesothelin Protein (Primary Amine Labeling), Mouse, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 35.2 kDa and the accession number is Q6146... | |||
TMPK-00181 | PD-1 Protein (Primary Amine Labeling), Mouse, Recombinant (hFc), Biotinylated | Mouse | HEK293 Cells |
Programmed cell death protein 1, also known as PD-1 and CD279 , is a protein found on the surface of cells that has a role in regulating the immune system's response to the cells of the human body by down-regulating the ... | |||
TMPK-00492 | IL-18BP Protein (Primary Amine Labeling), Cynomolgus, Recombinant (His), Biotinylated | Cynomolgus | HEK293 Cells |
Cytokines were the first modern immunotherapies to produce durable responses in patients with advanced cancer,components of the interleukin-18 (IL-18) pathway are upregulated on tumour-infiltrating lymphocytes, suggestin... | |||
TMPK-00231 | Siglec-15 Protein (Primary Amine Labeling), Mouse, Recombinant (His), Biotinylated | Mouse | HEK293 Cells |
Siglec-15 is a transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory molecules. Mature human Siglec-15 consists of a 244 amino acid extracellular domain (ECD) with two Ig-like domains, ... | |||
TMPK-01397 | MSLN/Mesothelin Protein (Primary Amine Labeling), Cynomolgus, Recombinant (His), Biotinylated | Cynomolgus | HEK293 Cells |
MSLN/Mesothelin Protein (Primary Amine Labeling), Cynomolgus, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 33 kDa and the accession number is A0... | |||
TMPK-00619 | FcRH5/FcRL5 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated | Human | HEK293 Cells |
FcRH5 is a cell surface marker enriched on malignant plasma cells when compared to other hematologic malignancies and normal tissues. DFRF4539A is an anti-FcRH5 antibody-drug conjugated to monomethyl auristatin E (MMAE),... | |||
TMPK-00169 | OX40/TNFRSF4 Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated | Human | HEK293 Cells |
Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), also known as CD134 and OX40 receptor. OX40 is a secondary co-stimulatory immune checkpoint molecule, expressed after 24 to 72 hours following activation; i... | |||
TMPK-00615 | NKp46/NCR1 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated | Human | HEK293 Cells |
NKp46, along with NKp30 and NKp44, are activating receptors that have been collectively termed the natural cytotoxicity receptors (NCR).These receptors lack significant sequence homology to one another. They are expresse... | |||
TMPK-00664 | GDF-15 Protein (Primary Amine Labeling), Cynomolgus, Recombinant (hFc), Biotinylated | Cynomolgus | HEK293 Cells |
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and t... | |||
TMPK-00198 | GDF-15 Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated | Human | HEK293 Cells |
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and t... | |||
TMPK-00720 | Siglec-5 Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated | Human | HEK293 Cells |
Group B Streptococcus (GBS) causes invasive infections in human newborns. the GBS β-protein attenuates innate immune responses by binding to sialic acid-binding immunoglobulin-like lectin 5 (Siglec-5), an inhibitory rece... | |||
TMPJ-00379 | AOC3 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
Membrane primary amine oxidase(AOC3), also known as vascular adhesion protein (VAP-1) and HPAO, this protein is a member of the semicarbazide-sensitive amine oxidase (SSAO) family. VAP-1 is a type 1 membrane-bound glycop... | |||
TMPK-00197 | GDF-15 Protein (Primary Amine Labeling), Human, Recombinant (H202D, hFc), Biotinylated | Human | HEK293 Cells |
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and t... | |||
TMPK-00763 | Apolipoprotein E/APOE3 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated | Human | HEK293 Cells |
Apolipoprotein E (apoE) is a lipid carrier in both the peripheral and the central nervous systems. Lipid-loaded apoE lipoprotein particles bind to several cell surface receptors to support membrane homeostasis and injury... | |||
TMPK-00154 | CD40 Ligand Protein (Primary Amine Labeling), Human, Recombinant (His & Flag), Biotinylated | Human | HEK293 Cells |
CD40 ligand or CD40L, also called CD154, is a protein that is primarily expressed on activated T cells and is a member of the TNF superfamily of molecules. It binds to CD40 (protein) on antigen-presenting cells (APC), w... | |||
TMPK-00081 | FGF-7/KGF Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated | Human | E. coli |
The expression patterns of mRNAs encoding Fibroblast Growth Factor-7 (FGF-7) and its high affinity receptor suggested that FGF-7 signaling may play a role in regulating ureteric bud growth.t Results of these studies demo... | |||
TMPK-00054 | GITR Ligand/TNFSF18 Protein (Primary Amine Labeling), Human, Recombinant (His & Flag), Biotinylated | Human | HEK293 Cells |
Glucocorticoid-induced TNFR-related protein (TNFRSF18, GITR, CD357), expressed by T cells, and its ligand (TNFSF18, GITRL), expressed by myeloid populations, provide co-stimulatory signals that boost T cell activity. Due... | |||
TMPK-00259 | Latent TGF beta 3 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated | Human | HEK293 Cells |
Transforming growth factor-betas (TGF-βs) are multifunctional cytokines that have been implicated in the regulation of a broad range of biological processes, including cell proliferation, cell survival, and cell differen... | |||
TMPK-00951 | CDH17 Domain 5-7 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated | Human | HEK293 Cells |
Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating... | |||
TMPJ-00380 | AOC3 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Vascular adhesion protein-1(VAP-1) is a copper amine oxidase with a topaquinone cofactor.VAP-1 is a type II integral membrane protein, but a soluble form of the enzyme is present in human serum, and its level increases i... | |||
TMPK-00321 | IL-2 R beta/CD122 Protein (Primary Amine Labeling), Cynomolgus, Recombinant (His), Biotinylated | Cynomolgus | HEK293 Cells |
IL-2 R beta/CD122 Protein (Primary Amine Labeling), Cynomolgus, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 25.6 kDa and the accession number i... | |||
TMPK-00987 | IL-2 R gamma/CD132 Protein (Primary Amine Labeling), Cynomolgus, Recombinant (His), Biotinylated | Cynomolgus | HEK293 Cells |
The gamma chain of the high affinity functional human IL-2 receptor complex belongs to the hematopoietin receptor family. IL-2 R gamma is a 369 amino acid residue protein consisting of a 22 residue signal sequence, a 232... | |||
TMPJ-00700 | GADD45B Protein, Human, Recombinant (His) | Human | E. coli |
Growth Arrest and DNA Damage-Inducible Protein GADD45 β (GADD45B) is a member of the GADD45 family. GADD45B has been shown to interact with MAP3K4, ASK1, MAP2K7, and GADD45GIP1. GADD45B is involved in the regulation of g... | |||
TMPY-05030 | PCDH7 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
PCDH7, a member of protocadherins family, functions as tumor suppressor in several human cancers. The human PCDH7 gene is localized in chromosome 4p15, which is often inactivated in human cancers, including bladder cance... | |||
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カタログ番号 | 製品名 | ||
---|---|---|---|
L2500 | Human Endogenous Metabolite Library | 499 compounds | |
A collection of 499 selected human endogenous metabolites for high throughput and high content screening. | |||
L2196 | Anti-Ovarian Cancer Compound Library | 1867 compounds | |