Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BT2, a BCKDC kinase (BDK) inhibitor, exhibits an IC50 of 3.19 μM and functions as a potent, selective Mcl-1 inhibitor with a Ki value of 59 μM. Its interaction with BDK induces helix movements in the N-terminal domain, leading to BDK's dissociation from the branched-chain α-ketoacid dehydrogenase complex (BCKDC).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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10 mg | 在庫あり | ¥ 9,000 | |||
25 mg | 在庫あり | ¥ 13,500 | |||
50 mg | 在庫あり | ¥ 16,500 | |||
100 mg | 在庫あり | ¥ 24,000 | |||
500 mg | 在庫あり | ¥ 59,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 9,000 |
説明 | BT2, a BCKDC kinase (BDK) inhibitor, exhibits an IC50 of 3.19 μM and functions as a potent, selective Mcl-1 inhibitor with a Ki value of 59 μM. Its interaction with BDK induces helix movements in the N-terminal domain, leading to BDK's dissociation from the branched-chain α-ketoacid dehydrogenase complex (BCKDC). |
ターゲット&IC50 | BDK:3.19 μM (IC50), MCL1:59 μM (Ki) |
In vivo | BT2 treatment reduces the protein levels of BDK in kidneys and heart. The -fold activation of BCKDC activity in the above tissues correlates with decreased phosphorylation in heart, muscle, and kidney after the long term BT2 treatment. BT2 (20 mg/kg/day; i.p.; daily; for 7 days; C57BL/6J male mice) treatment robustly enhances BCKDC activity in the heart (12.3-fold) compared with the vehicle-treated animals. Less activation is obtained in muscle and kidney at 3.6- and 3.8-fold, respectively [1]. |
分子量 | 247.1 |
分子式 | C9H4Cl2O2S |
CAS No. | 34576-94-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 83.33 mg/mL (337.23 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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BT2 34576-94-8 Apoptosis BCL Bcl-2 Family Inhibitor inhibit BT 2 BT-2 inhibitor