Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BTB06584 is an IF1-dependent, selective inhibitor of the mitochondrial F1 Fo-ATPase. BTB06584 is a novel acetohydroxyacid synthase(AHAS) inhibitor, a promising drug target against Mycobacterium tuberculosis (MTB).
説明 | BTB06584 is an IF1-dependent, selective inhibitor of the mitochondrial F1 Fo-ATPase. BTB06584 is a novel acetohydroxyacid synthase(AHAS) inhibitor, a promising drug target against Mycobacterium tuberculosis (MTB). |
In vitro | BTB06584 restores defective hemoglobin synthesis in zebrafish pinotage (pnt) mutants without evident toxicity. |
In vivo | BTB06584 inhibits F1Fo-ATPase activity in an IF1-dependent manner, does not affect ATP synthesis, and also restricts ischemia-induced damage caused by the reverse action of mitochondrial F1Fo-ATP synthase. |
分子量 | 417.82 |
分子式 | C19H12ClNO6S |
CAS No. | 219793-45-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 78 mg/mL (186.7 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
BTB06584 219793-45-0 Endocrinology/Hormones Membrane transporter/Ion channel ATPase RAAS IF1 mitochondrial cardioprotective ATP Synthase ATPsynthase ischaemic BTB-06584 inhibit Inhibitor BTB 06584 inhibitor