Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Barlerin (8-O-Acetylshanzhiside methyl ester) has potential against cerebral ischemic injury, and its protective effect on oxygen-glucose deprivation-induced injury might be due to the suppression of intracellular Ca2+ elevation and caspase-3 activity, and improvement of mitochondrial energy metabolism.8-O-Acetylshanzhiside methylester can increase angiogenesis and improve functional recovery after stroke.8-O-Acetylshanzhiside methylester has protective effects on experimental myocardial ischemia injury, the effects might be due to block of myocardial inflammatory cascades through an HMGB1-dependent NF-κB signaling pathway.8-O-Acetylshanzhiside methylester protects diabetic brain against I/R injury by alleviating diabetic cerebral I/R injury and attenuating blood–brain barrier (BBB) breakdown, and its protective effects may involve HMGB-1 and NF-κB signalling pathway.
説明 | Barlerin (8-O-Acetylshanzhiside methyl ester) has potential against cerebral ischemic injury, and its protective effect on oxygen-glucose deprivation-induced injury might be due to the suppression of intracellular Ca2+ elevation and caspase-3 activity, and improvement of mitochondrial energy metabolism.8-O-Acetylshanzhiside methylester can increase angiogenesis and improve functional recovery after stroke.8-O-Acetylshanzhiside methylester has protective effects on experimental myocardial ischemia injury, the effects might be due to block of myocardial inflammatory cascades through an HMGB1-dependent NF-κB signaling pathway.8-O-Acetylshanzhiside methylester protects diabetic brain against I/R injury by alleviating diabetic cerebral I/R injury and attenuating blood–brain barrier (BBB) breakdown, and its protective effects may involve HMGB-1 and NF-κB signalling pathway. |
植物由来 |
別名 | 8-O-Acetylshanzhiside methyl ester, ND01 |
分子量 | 448.42 |
分子式 | C19H28O12 |
CAS No. | 57420-46-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 82 mg/mL(182.9 mM)
You can also refer to dose conversion for different animals. 詳細
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Barlerin 57420-46-9 Angiogenesis Apoptosis Cytoskeletal Signaling NF-Κb PI3K/Akt/mTOR signaling Proteases/Proteasome Tyrosine Kinase/Adaptors Caspase VEGFR Akt NF-κB TNF inhibit Inhibitor ND-01 8-O-Acetylshanzhiside methyl ester Nuclear factor-κB ND 01 Nuclear factor-kappaB ND01 inhibitor