Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CCT020312 is a selective activator of EIF2AK3 and PERK. CCT020312 durably inhibits cell proliferation and elicits the phosphorylation of EIF2A.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 14,500 | |||
5 mg | 在庫あり | ¥ 33,500 | |||
10 mg | 在庫あり | ¥ 58,500 | |||
25 mg | 在庫あり | ¥ 98,500 | |||
50 mg | 在庫あり | ¥ 146,000 | |||
100 mg | 在庫あり | ¥ 203,000 | |||
500 mg | 在庫あり | ¥ 420,000 |
説明 | CCT020312 is a selective activator of EIF2AK3 and PERK. CCT020312 durably inhibits cell proliferation and elicits the phosphorylation of EIF2A. |
In vitro | In HT29 cells, CCT020312 reduces the P-S608-pRB signal with a linear response between 1.8 and 6.1 μM in a concentration-dependent manner. CCT020312(10 μM) decreases G1/S cyclins D1, D2, E, and A, reduces the CDK catalytic subunit CDK2 and increased the level of the p27KIP1[1]. |
In vivo | In wild-type mice, intraperitoneal injection of CCT020312 (1-5 mg/kg) increases PERK and NRF2 phosphorylation of brain homogenates. In P301S tau transgenic mice, intraperitoneal injection of CCT020312 (2 mg/kg) behaves better in the Morris water maze test[2]. |
分子量 | 650.4 |
分子式 | C31H30Br2N4O2 |
CAS No. | 324759-76-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90.0 mg/mL (138.4 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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CCT020312 324759-76-4 Apoptosis PERK CCT-020312 CCT 020312 Inhibitor inhibitor inhibit