Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CFM-2, a potent and selective non-competitive antagonist of AMPAR (AMPAR), exhibits anticonvulsant activity across various seizure models.
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1 mg | 在庫あり | ¥ 9,000 | |||
5 mg | 在庫あり | ¥ 21,000 | |||
10 mg | 在庫あり | ¥ 31,500 | |||
25 mg | 在庫あり | ¥ 60,000 | |||
50 mg | 在庫あり | お問い合わせ | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 23,000 |
説明 | CFM-2, a potent and selective non-competitive antagonist of AMPAR (AMPAR), exhibits anticonvulsant activity across various seizure models. |
In vitro | CFM-2 inhibits the extracellular signal-regulated kinase (ERK1/2) pathway, reduces phosphorylation of cAMP-responsive element-binding protein (CREB), and suppresses cyclin D1 expression. It upregulates cell cycle regulators and tumor suppressor proteins p21 and p53, consequently decreasing lung adenocarcinoma cell populations in the G2 and S phases of the cell cycle. |
In vivo | Pretreatment with CFM-2 delayed the progression of seizure rank during repeated administration of pentylenetetrazole. At the end of the period of repeated pentylenetetrazole treatment (6 weeks), the mean seizure score was 0 in vehicle-treated controls, 4.3 in animals treated with vehicle + pentylenetetrazole, 2.2 in rats treated chronically with CFM-2 (20 μmol/kg i.p.) + pentylenetetrazole and 1.0 in rats treated repeatedly with CFM-2 (50 μmol/kg i.p.) + pentylenetetrazole. CFM-2 was also able to antagonize the long-term increase in sensitivity of the convulsant effects of GABA function inhibitors in pentylenetetrazole-kindled animals [1]. CFM-2 has been proven to possess anticonvulsant activity in various models of seizures [2]. Intrathecal application of two selective non-competitive AMPAR antagonists, CFM-2 (25 and 50 μg) and GYKI 52466 (50 μg), significantly attenuated mechanical and thermal hypersensitivities on the ipsilateral hind paw at 2 and 24 h post-CFA injection. Neither CFM-2 nor GYKI 52466 affected the contralateral basal responses to thermal and mechanical stimuli [4]. |
分子量 | 311.34 |
分子式 | C17H17N3O3 |
CAS No. | 178616-26-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45mg/mL (144.5mM)
You can also refer to dose conversion for different animals. 詳細
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CFM-2 178616-26-7 Membrane transporter/Ion channel Neuroscience iGluR CFM2 CFM 2 Inhibitor inhibitor inhibit