Powder: -20°C for 3 years | In solvent: -80°C for 1 year
YM90K (6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-) hydrochloride is an antagonist of AMPA receptor.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 30,500 | |||
2 mg | 在庫あり | ¥ 45,500 | |||
5 mg | 在庫あり | ¥ 68,500 | |||
10 mg | 在庫あり | ¥ 104,000 | |||
25 mg | 在庫あり | ¥ 171,500 | |||
50 mg | 在庫あり | ¥ 241,000 | |||
100 mg | 在庫あり | ¥ 326,000 |
説明 | YM90K (6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-) hydrochloride is an antagonist of AMPA receptor. |
ターゲット&IC50 | AMPA receptor:84 nM (Ki), Kainate receptor:2.2 μM (Ki), NMDAR:37 μM (Ki) |
In vivo | In a global ischemia model, YM90K (15 mg/kg i.p. x 3), NBQX (30 mg/kg i.p. x 3) and CNQX (60 mg/kg i.p. x 3) significantly prevented the delayed neuronal death in the hippocampal CA1 region in Mongolian gerbils when administered 1 h after 5-min ischemia.?In addition, the therapeutic time window for the neuroprotective effect of YM90K (30 mg/kg i.p. x 3) was 6 h. In a focal ischemia model, YM90K (30 mg/kg i.v. bolus+10 mg/kg/h for 4 h) reduced the volume of ischemic damage in the cerebral cortex in F344 rats[1]. |
別名 | YM90K hydrochloride, 6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)- |
分子量 | 309.66 |
分子式 | C11H8ClN5O4 |
CAS No. | 154164-30-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: Slightly soluble
You can also refer to dose conversion for different animals. 詳細
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YM90K 154164-30-4 Membrane transporter/Ion channel Neuroscience iGluR GluR anticonvulsant AMPA Inhibitor ischemia inhibit neuroprotective Ionotropic glutamate receptors YM90K hydrochloride YM-90K 6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)- YM90K Hydrochloride inhibitor