Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CH-223191 is a potent and specific antagonist for aryl hydrocarbon receptor (AhR).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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5 mg | 在庫あり | ¥ 13,000 | |||
10 mg | 在庫あり | ¥ 22,500 | |||
25 mg | 在庫あり | ¥ 41,000 | |||
50 mg | 在庫あり | ¥ 68,000 | |||
100 mg | 在庫あり | ¥ 118,500 | |||
200 mg | 在庫あり | ¥ 170,000 | |||
500 mg | 在庫あり | ¥ 264,000 |
説明 | CH-223191 is a potent and specific antagonist for aryl hydrocarbon receptor (AhR). |
ターゲット&IC50 | AhR:30 nM |
In vitro | Daily oral administration of 10 mg/kg CH-223191 effectively prevents cytochrome P450 induction, wasting syndrome, and hepatotoxicity in mice caused by exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin. |
In vivo | CH-223191 downregulates the TGF-β/Smad pathway in human glioblastoma cells, consequently reducing clonogenic survival and invasiveness. In neuron cells derived from human SK-N-SH, it counteracts the suppression of neuronal acetylcholinesterase expression induced by TCDD. Moreover, CH-223191 blocks the nuclear translocation and DNA binding of AhR mediated by TCDD and also inhibits the activation of cytochrome P450 enzyme activity induced by TCDD. Additionally, CH-223191 enhances the expression of ICAM-1 in endothelial cells and prevents the nuclear translocation of RelB. |
別名 | CH 223191 |
分子量 | 333.39 |
分子式 | C19H19N5O |
CAS No. | 301326-22-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 3.3 mg/mL (10 mM)
DMSO: 33.3 mg/mL (100 mM)
5% DMSO+95% Saline: 1.67 mg/mL (4.99 mM, suspension)
You can also refer to dose conversion for different animals. 詳細
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CH-223191 301326-22-7 Immunology/Inflammation Metabolism AhR Aryl Hydrocarbon Receptor Inhibitor inhibit CH223191 CH 223191 inhibitor