Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CHK1-IN-3 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 0.4 nM).
説明 | CHK1-IN-3 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 0.4 nM). |
ターゲット&IC50 | Chk1:0.4 nM |
In vitro | CHK1-IN-3 displays a low affinity for hERG (IC50 > 40 µM). CHK1-IN-3 effectively inhibits the growth of malignant hematopathy cell lines especially Z-138 (IC50: 0.013 µM)[1]. |
In vivo | In the Z-138 cell inoculated xenograft model, CHK1-IN-3 significantly suppresses the tumor growth as a single agent with bodyweight unaffected[1]. |
分子量 | 405.46 |
分子式 | C20H23N9O |
CAS No. | 2097252-39-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (135.65 mM)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
CHK1-IN-3 2097252-39-4 Cell Cycle/Checkpoint Chk CHK1IN3 CHK1 IN 3 CHK-1-IN-3 Inhibitor inhibitor inhibit