store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tuvusertib (M1774) is an orally available ataxia telangiectasia and Rad3-related (ATR) kinase inhibitor (Ki< 1 µΜ) with selective and potentially antitumor activity.Tuvusertib selectively inhibits ATR activity and blocks downstream phosphorylation of serine/threonine protein kinase checkpoint kinase 1 (CHK1), thereby inhibits DNA damage checkpoint activation, disrupting DNA damage repair and inducing apoptosis in tumor cells.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 16,000 | |||
5 mg | 在庫あり | ¥ 38,000 | |||
10 mg | 在庫あり | ¥ 59,000 | |||
25 mg | 在庫あり | ¥ 114,000 | |||
50 mg | 在庫あり | ¥ 159,000 | |||
100 mg | 在庫あり | ¥ 225,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 43,000 |
説明 | Tuvusertib (M1774) is an orally available ataxia telangiectasia and Rad3-related (ATR) kinase inhibitor (Ki< 1 µΜ) with selective and potentially antitumor activity.Tuvusertib selectively inhibits ATR activity and blocks downstream phosphorylation of serine/threonine protein kinase checkpoint kinase 1 (CHK1), thereby inhibits DNA damage checkpoint activation, disrupting DNA damage repair and inducing apoptosis in tumor cells. |
別名 | M1774, ATR inhibitor 1 |
分子量 | 370.32 |
分子式 | C16H12F2N8O |
CAS No. | 1613200-51-3 |
store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 6.25 mg/mL (16.88 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Tuvusertib 1613200-51-3 Apoptosis Cell Cycle/Checkpoint DNA Damage/DNA Repair Others PI3K/Akt/mTOR signaling Chk ATM/ATR M1774 M 1774 ATR inhibitor 1 M-1774 Inhibitor inhibitor inhibit