Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CHMFL-ABL-121 is a highly potent inhibitor of type II ABL kinase (IC50s: 2 nM and 0.2 nM against purified inactive ABL wt and T315I kinase protein).
説明 | CHMFL-ABL-121 is a highly potent inhibitor of type II ABL kinase (IC50s: 2 nM and 0.2 nM against purified inactive ABL wt and T315I kinase protein). |
ターゲット&IC50 | Abl (WT):2 nM, Abl (T315I):0.2 nM |
In vitro | CHMFL-ABL-121 induces apoptosis and arrests the cell cycle at the G0/G1 phase. CHMFL-ABL-121 dose-dependently inhibits BCRABL's auto-phosphorylation at the Y245 site in MEG-01 (EC50<10 nM), K562 (EC50<10 nM), and KU812 (EC50<30 nM) cells and also significantly blocks the phosphorylation of downstream signaling mediators STAT5, CrkL, and ErK[1]. |
分子量 | 580.67 |
分子式 | C30H31F3N6OS |
CAS No. | 2270879-07-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (94.72 mM)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
CHMFL-ABL-121 2270879-07-5 Angiogenesis Cytoskeletal Signaling Tyrosine Kinase/Adaptors Bcr-Abl CHMFL-ABL121 CHMFL-ABL 121 CHMFLABL121 CHMFL ABL 121 Inhibitor inhibitor inhibit